WEEK 6 Prostate Disorders Flashcards
(114 cards)
What is Benign Prostatic Hyperplasia (BPH)?
Glandular units in the prostate that undergo an increase in number of cells (HYPERPLASIA), resulting in enlargement of prostate gland - inflammation occurs!
What are the risk factors for BPH? (7)
- Aging
- Obesity (“apple”)
- Lack of physical activity
- Alcohol consumption
- Erectile dysfunction
- Smoking
- Diabetes
BPH is influenced by __
androgens !
What are symptoms of BPH? (11)
- Hyperirritable bladder
- Urgency and frequency
- Hypertrophied bladder wall muscles
- Cellules and diverticula
- Hydroureter
- Hydronephrosis
- Overflow urinary incontinence
- Urinary retention
- Nocturia
- they might have to strain
- stream itself might be very weak
In BPH, prostate grows __ causing narrowing of the __.
inward
urethra
The prostate should be __, __ __, and should not be __.
soft, freely movable
hard
In __, the patient has similar symptoms as an individual with BPH
prostatitis
For a patient with BPH, the ureter can become __, when urine is __ __ if outflow is completely obstructed from prostate enlargement. Stones can form from __ __ and __ __. When the urine backs up all the way to the __, hydronephrosis can occur.
irritable
backed up
urinary retention; urinary stasis
kidney
What are diagnostic studies for BPH? (6)
- Digital rectal exam
- Urine analysis and culture
- Serum creatinine and BUN
- PSA (Prostate Specific Antigen)
- Urodynamic flow studies
- Cystourethroscopy
What are treatment goals for BPH? (3)
- Restore bladder drainage
- Relieve symptoms
- Prevent/Treat complications
What drug therapies are used for individual with BPH? (4)
- Hormonal manipulation (androgen)
- Alpha-adrenergic blockers
- Conservative therapy
- Invasive therapy
What androgen is used in hormonal manipulation as a drug therapy method for BPH pts?
Proscar (finasteride)
What is Proscar (finasteride)? What is its mechanism of action?
A 5-alpha-reductase inhibitor. Mechanism of Action: inhibits enzymes that converts testosterone to a potent androgen dihydrotestosterone (DHT), which the prostate glad need for its development. “Shrinks” the prostate.
When administering Proscar (finasteride), what should you remember to do?
wear gloves! there’s some degree of androgens within it
One should check __ before conducting a __ __ __ b/c the __ can be ELEVATED if __ is done first
PSA
digital rectal exam
PSA
DRE
When can PSA levels be falsely elevated?
- when doing a digital rectal exam before getting PSA levels
- when foley catheter is inserted before getting PSA levels
If the PSA is greater than __, a __ is done because they may potentially have prostate cancer
4
biopsy
If PSA is less than __, a patient may still have __ __
4
prostate cancer
What are 3 examples of alpha-adrenergic blockers used in drug therapy for BPH pts?
- Minipress
- Cardura
- Hytrin
What do alpha-adrenergic blockers to help BPH pts?
they relax smooth muscle and increase urinary flow
What are side effects of alpha-adrenergic blockers?
- orthostatic hypotension
2. dizziness
When are alpha-adrenergic blockers normally given?
They are typically given at night
What two things are used in conservative therapy for the BPH pt?
- stents, prostatic balloon
2. foley catheters
What does the invasive therapy for the BPH pt consist of?
TURP