Week 7: Cardiac Glycoside Flashcards Preview

NURP 424 Adv Pharm > Week 7: Cardiac Glycoside > Flashcards

Flashcards in Week 7: Cardiac Glycoside Deck (7)
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1
Q

Digoxin MOA

A
  • inhibits the Na/K pump which causes Na to build up in cell
  • this results in a decrease in the sodium calcium transport mechanism causing calcium build up in cell too
  • decreased extracellular calcium decreased the muscle contraction and increases the force of the contraction
  • vagal tone is enhanced which decreases heart rate and oxygen demand
  • *positive inotropic and slightly negative chronotropic effects
2
Q

Digoxin indictions

A
  • symptomatic heart failure
  • SVT
  • atrial fibrillation
3
Q

Digoxin cautions/ contraindictions

A
  • narrow TI
  • avoid in AV block and uncontrolled ventricular arrhythmias
  • caution in electrolyte abnormalities, renal, hepatic impairment
  • caution in elderly
4
Q

Digoxin ADRs

A
  • nausea, vomiting, visual disturbance (yellow or green halos), chest pain, palpitations, fatigue
    • if patient is taking digoxin and c/o nausea and vomiting - think dig toxicity **
5
Q

Digoxin patient education

A
  • take at the same time each day
  • do not double doses
  • monitor for signs of toxicity (educate pt on s/s of toxicity)
  • take pulse for heart rate - if < 60 or > 100 hold dose and notify PCP
6
Q

early signs of digoxin toxicity

A

yellow and green halo

7
Q

late signs of digoxin toxicity

A

irregular heartbeat, palpitations (pounding HR)

Decks in NURP 424 Adv Pharm Class (63):