Week 7 Medications and BOXED WARNINGS Flashcards
Factor Xa Inhibitor
“Direct Oral Anticoagulant (DOAC)”
BOXED WARNING:
- Premature discontinuation increases risk of thrombotic events
- Epidural or spinal hematomas may occur in patients who are receiving neuraxial anesthesia or undergoing spinal puncture
edoxaban - Savaysa
BOXED WARNING:
- Reduced efficacy in nonvalvular atrial fibrillation patients with CrCl > 95 mL / minute
Direct Thrombin Inhibitor
“Direct Oral Anticoagulant (DOAC)”
BOXED WARNING:
- Premature discontinuation increases risk of thrombotic events
- Epidural or spinal hematomas may occur in patients who are receiving neuraxial anesthesia or undergoing spinal puncture
warfarin - Coumadin, Jantoven
BOXED WARNING:
- warfarin can cause major or fatal bleeding. Perform regular monitoring of International Normalized Ratio (INR) on all treated patients
ticagrelor - Brilinta
BOXED WARNING:
- Can cause significant, sometimes fatal, bleeding. Do not use in active pathological bleeding or history of Intracranial hemorrhage
- Aspirin dose and ticagrelor effectiveness in patients with acute coronary syndrome: maintenance doses of aspirin > 100 mg daily reduce the effectiveness of ticagrelor and should be avoided
clopidogrel - Plavix
BOXED WARNING:
- Clopidogrel is a prodrug; therefore, reduced antiplatelet activity in patients who are homozygous for nonfunctional alleles of CYP2C19 gene (termed “poor metabolizers”). Consider use of another platelet P2Y12 inhibitor in these patients
prasugrel - Effient
BOXED WARNING:
- Can cause significant, sometimes fatal, bleeding. Do not use in patients with active pathological bleeding or a history of transient ischemic attack (TIA) or stroke. In patients ≥ 75 years old, prasugrel is generally not recommended (bleeding risk)
atorvastatin
Lipitor
lovastatin
Altoprev
Mevacor
pravastatin
Pravachol
rosuvastatin
Crestor
simvastatin
Zocor
ezetimibe
Zetia
colesevelam
Welchol
icosapent ethyl
Vascepa
