Week 8-Sleep Flashcards
(38 cards)
Sleep Cycles
- Cyclic cycle
- One of the organs that benefits the most from sleep is the BRAIN
- Sleep tends to decrease as we get older
- Sleep varies from animals Bats (20hrs) to horses (3hrs); humans (8hrs)
- Aquatic animals such as dolphins sleep one hemisphere at a time (Unihemespheric sleep). The alternation between two hemispheres
- Preferences (night owl or morning lark)-chronotype- classification prone to be asleep or awake. Genes-Reflect innate differences in the circadian period, and how easily a rhythm can be synchronised to the night-day cycle. More than half of people (in industrialised societies) may have circadian rhythms out of phase with the schedule they keep for work/school “social jet lag”. People can feel very tired during the day.
The functions of sleep and their importance
Role in: Recuperation; Growth; Mental function(bidirectional between sleep and mental disorders e.g. sleep disrupted onset for Alzheimer’s disease)
What is sleep?
A periodic, natural, reversible behavioural state of perceptual disengagement from, and unresponsiveness to, the environment (Steinberg, 2007)
Different from:
- Hibernation
- Being in a coma; On anaesthetic (irreversible)
How is sleep measured?
POLYSOMONOGRAPHY (Multiple, sleep, writing)
Multiparametric test and used in sleep medicine
Recording of multiple signals during sleep:
- EEG – brain
- EMG – muscle activation (mild increase in muscle tension)
- EOG – eye movements
- Heart rate
- Respiration
Polysomnogram
What is sleep deprivation?
Sleep deprivation causes negative impacts on :
- Mood
- Cognitive performance
- Executive attention
- Working memory
- Motor function
Sleep deprivation can cause numerous problems.
Gardner stayed awake 11days in 1965.
After 2 days: irritable, nauseated, memory problems, could not watch TV anymore
After 4 days: mild delusions, overwhelming fatigue
After 7 days: tremor, language problems, EEG abnormality
After the end of the trial: normalised quickly again (not true for some animals deprived of sleep).
What is sleep deprivation?
Sleep deprivation causes negative impacts on :
- Mood
- Cognitive performance
- Executive attention
- Working memory
- Motor function
- Deficits accumulate overtime. Negative impacts on wellbeing.
Sleep deprivation can cause numerous problems.
Gardner stayed awake 11days in 1965.
After 2 days: irritable, nauseated, memory problems, could not watch TV anymore
After 4 days: mild delusions, overwhelming fatigue
After 7 days: tremor, language problems, EEG abnormality
After the end of the trial: normalised quickly again (not true for some animals deprived of sleep).
What is a hypnogram?
A graph which represents ones sleep cycle and awakenings during the night.
What is REM sleep?
Rapid Eye Movement Sleep
REM = lots of extrastriate activity (internally generated visual imagery) Visual processing and dreams- more activity in the brain stem
Mostly dream during REM sleep
Heart rate; respiration; penal erection increases during REM sleep and decreases during non-REM sleep
Define sleep as a mechanism
Sleep is an active process that requires the participation of a variety of brain regions and transmitters.
Hormones-Cortisol and sleep
Cortisol oscillates throughout the day, but peaks just before you wake up.
Poor sleep–>Higher levels of cortisol
Hormones-Melatonin and sleep
Melatonin higher at night, lower in the morning.
Made in pineal gland.
(Nuclear clock)
What neurotransmitters are involved in the sleep-wake cycle?
Arousal promoting:
- Noradrenaline (locus coeruleus)
- Serotonin (raphe nuclei)
- Acetylcholine (brain stem, basal forebrain)
- Histamine (midbrain)
- Hypocretin (hypothalamus) –> excites all other systems (loss –> narcolepsy)
–>synapse on thalamus & cerebral cortex –>depolarisation of neurons–> increase excitability
Neurotransmitters arousal (promoting) sleep
Promoting sleep:
- Decreases firing rate of most brain stem modulatory neurons
- GABA
- Adenosine: facilitates sleep (caffeine is antagonist)
- ->It inhibits systems which promote wakefulness
- levels progressively increase during prolonged waking and decrease during sleep
- Some ACh neurons fire to induce REM – produces eye activity
- Dopamine:- modules REM sleep, contributes to dream generation (internal, exploratory environment)
Neurotransmitters involved in going to sleep
- Increase of GABAergic activity in cortex
- Deactivation of locus coeruleus (noreadrenaline)
- Less activity of reticular activating system
- Reduced histamine and hypocretin (hypothalamus)
- Increase melatonin (pineal gland)
Which 2 processes control sleep?
- Circadian Clock(Alerting signal-internal clocks and internal processes)
- Sleep Homeostasis(Sleep Pressure- the longer we are awake more sleep pressure)
Dual Process model of sleep
Sleep-wake homeostasis
Sleep-wake homeostasis (S) accumulation of hypnogenic substances in the brain that promote sleep (e.g., adenosine)
Circadian rhythm (C) regulates the body’s internal processes and alertness
Circadian rhythm (about a day rhythm)
- Even organisms without a brain (e.g., plants) react to day/night
- TO MAINTAIN SLEEP-WAKE CYCLES (Day night rhythms) Name for external cues: zeitgebers (”time givers”)
- Help to entrain the day/night rhythm
Without zeitgebers, rhythms run free (Dement, 1976)
How did scientists conduct experiments to learn more about circadian rhythms?
- Slept in Deep caves for months and recorded sleep-wake cycles
- Wake/sleep, lights on/off, eating –> all whenever they like
- Initially day was 25 hours, then it rose to 30-36 hours (stay awake 20 hours, sleep 12 hours)
- Desynchronised: sleep and body temperature
-Criticism > constant dim light conditions (~ 24h rhythms)-MORE LAB CONDITIONS
Biological Clock
-SCN (suprachiasmatic nuclei) Only 0.3mm3-INTERNAL BIOLOGICAL CLOCK FROM OUR EYES
-Within hypothalamus
-Receives input from the retina –> light-sensitive ganglion cells
Ganglion cells:
-large, nonselective receptive fields responding to luminance
-Not rods or cones –> new photoreceptor that’s slowly excited by light –> signal to SCN
Jet lag
- Jet lag is a mismatch between internal and external clocks
- Adjusting eastwards is harder as our clock is slightly more than 24 hours -Circadian rhythm longer
Consequences:
- Elevates cortisol
- Sleepless/ fatigue (melatonin disruption)
- Loss of concentration
- Change in appetite (ghrelin)
- Body temperature fluctuations
Best way to combat it:
- Restrict light exposure/ meals/ activity
- Can take a supplement of melatonin
What are the different types of sleep disorders?
Diagnostic manuals (e.g., DSM-V)
Main categories:
-Insomnias (difficulty going to sleep/ staying asleep)
-Hypersomnolence (daytime sleeping e.g., narcolepsy)
-Parasomnias (disorders that disrupt sleep – e.g., sleepwalking)
-Circadian rhythm disorders (timing of sleep)
-Breathing disorders (E.g., sleep apnea)
Note: causes and symptoms are all very different
What is INSOMNIA?
What are the causes?
Common condition- difficult to fall and stay asleep.Disorder not due to a substance or known physiological condition.
- 30% of the population report one or more of the symptoms of insomnia.
- 10% fulfil diagnostic criteria
Causes:
- Overactive thyroid
- Mental or physical health
- Medication
- Stress
- Environmental factors
- Ultra levels of cortisol
What are Parasomnias?
Group of sleep disorders that involve unwanted events or experiences that occur while you are falling asleep, sleeping or waking up. AROUSAL during sleep, behaving inappropriately during sleep.
May include abnormal movements, behaviours, emotions, perceptions or dreams
You remain asleep during the event and often have no memory that it occurred.
More common in children because of brain immaturity.
- Sleepwalking
- Night terrors
- Restless leg syndrome
- Periodic limb movements
- Sexsomnia
- Sleep-related eating disorder
- REM sleep behaviour disorder
What is REM sleep behaviour disorder and what happens within it?
What is the treatment?
- Sleep paralysis is absent (can move a lot during REM sleep)
- Most patients are male
- Impairments Descending activity from the brain to muscles usually blocked by pons
- Pons lesioned –> REM behaviour disorder
People start acting out their dreams (can be violent at times when muscles activated)
-Can also be related to some other conditions (e.g., Parkinson’s)
Treatment:- benzodiazepines or melatonin