Week 9 - Diabetes and Mental Health (B) Flashcards

1
Q

Outline what a mini mental state examination tests for, including the rough categories

A

Tests for impaired cognition, especially in relation to dementia or head injury

Shouldn’t be used to make a diagnosis, but can be used to indicate the presence of cognitive impairment

Rough categories - ‘CORRAL’:
- Copying / drawing
- Orientation
- Registration
- Recall
- Attention
- Language

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2
Q

Outline what the scores from a MMSE mean, including the maximum score possible

A

Maximum score possible = 30

25 to 30 = normal
21 to 24 = mild cognitive impairment
10 to 20 = moderate cognitive impairment
< 10 = severe impairment cognitive impairment

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3
Q

Outline what a GP assessment of cognition test is used for and roughly outline what the 2 halves entail

A

GPCOG was developed as a more practical tool as the MMSE was too difficult to use in general practice (takes 4 mins rather than 10)

Part 1 - ask patient about various details including the date, draw a clock face and recent news events

Part 2 - speak to relative / close friend (informant) about what patient is like compared to a few years ago

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4
Q

Outline the range of scores for GPCOG, including max score possible and what they mean (part 1 and part 2)

A

Part 1: max score possible = 9
9 = no significant cognitive impairment, no further testing
5 to 8 = proceed to Part 2, informant section
0 to 4 = cognitive impairment, conduct further investigations

Part 2: max score possible = 6
Count number of ‘no issues’
4-6 ‘no issues’ = no cognitive impairment
0-3 ‘no issues’ = cognitive impairment, conduct further investigations

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5
Q

List some factors that may increase someone’s risk of suicide (non-modifiable, medical-related, modifiable)

A

Non-modifiable:
- Male gender
- Family history of mental disorder / suicidal thoughts / suicide

Medical:
- Other mental health issues: severe depression / anxiety / personality disorder
- Recent discharge from psychiatric inpatient care
- Physical illness (especially recently diagnosed, chronic or painful)

Modifiable:
- History of previous suicide attempts / self-harm
- Alcohol / drug abuse
- Exposure to suicidal behaviour
- Access to resources / means

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6
Q

List some protective factors against suicide

A
  • Social support e.g. friends / family
  • Religious beliefs
  • Responsibility of children (especially young children)
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7
Q

Outline the similarities and differences between suicide and self-harm

A

The key difference between self-harm and suicide is intent, despite having similar risk factors

Self-harm:
- Destructive behavior without any intention of suicide
- Usually used to cope with their feelings and stressors
- Coping strategy for preserving and enhancing life, not ending their life

Suicide:
- Intent to end their life due to ending their suffering
- Usually comes from a place of despair, hopelessness, and worthlessness

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8
Q

Outline some resources for patients experiencing suicidal ideation

A

NHS 111 (24 hours)
Samaritans (24 hours)
PAPYRUS (mainly during working hours)
Campaign Against Living Miserably or CALM (5pm-midnight)
Shout Crisis Text Line - can text “SHOUT”

Plus local charities / companies

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9
Q

List some risk factors associated with self-harm

A
  • Pre-existing depression or anxiety
  • Feelings of worthlessness / isolation
  • History of trauma / abuse
  • History of chronic stress
  • Alcohol or substance abuse (or previous)
  • High emotional perception and sensitivity
  • Poor effective mechanisms for dealing with emotional stress
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10
Q

Outline the relationship between self-harm and suicide

A
  • Presence of non-suicidal self-injury is a risk factor for suicidal thoughts and behaviors

Self-harm and suicide both indicate underlying distress, it is important to assess whether self-harming individuals are also suicidal

If so, provide the necessary treatment for individuals in both of these categories

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11
Q

Outline the management steps to be taken in someone presenting with self-harm

A
  • Assess injury severity and provide necessary treatment
  • Patient’s current emotional and mental state and level of distress
  • Assess whether there is immediate concern about the person’s safety and ASSESS SUICIDE RISK
  • Identify any safeguarding concerns

Management plan:
- CBT – starting asap
- Create a safety plan e.g. establish method, reduce risks if possible, identify barrier to treatment, identify coping strategies, establish protective factors
- Provide contact numbers for safety netting

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12
Q

Outline some reasons to refer a self-harm patient to a specialist mental health service for assessment

A
  • Increase in frequency or degree of self-harm / suicidal intent
  • Patient requests further support
  • Concern from professional or from patient’s family/friends
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13
Q

List some complications of T1DM
- Macrovascular
- Microvascular
- Metabolic
- Psychological
- Other

A

Macrovascular complications
- MI
- Stroke
- Peripheral arterial disease

Microvascular complications
- Retinopathy
- Nephropathy
- Neuropathy

Metabolic complications
- DKA
- Episodes of hypoglycaemia

Psychological complications
- Anxiety
- Depression
- Eating disorders
- Behavioural disorders, relationship difficulties and risk-taking behaviour

Increased risk of developing other autoimmune conditions e.g. thyroid disease, coeliac disease, Addison’s disease, and pernicious anaemia.

Reduced quality of life and life expectancy

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14
Q

Outline why the different microvascular and macrovascular complications occur

A

Macrovascular:
- Occurs due to chronic atherosclerosis, arteriosclerosis and inflammation
- Endothelial and smooth muscle dysfunction due to increased uptake of the glucose which doesn’t need insulin for this process (however glucose can’t actually reach the inside of the cell)
- Increased uptake of glucose leads to release of ROS, which causes inflammation and localised damage
- Dysfunctional endothelium allows LDLs into the cell and accelerates atherosclerosis
- Overall, leads to MI, stroke and peripheral arterial disease

Microvascular:
- Damaged caused by hypertension (from atherosclerosis and hyperglycaemia) causes blood vessel damage
- This reduces blood flow in small vessels in the eyes, kidneys and peripheral arteries leading to retinopathy, nephropathy and neuropathy

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15
Q

Outline how diabetes is diagnosed (including ranges)

A

Presence of one or more symptoms of diabetes:
- Polyuria
- Polydipsia
- Weight loss

Plus one of the following blood tests (need 2 if no symptoms, 1 week apart):
- Random plasma glucose concentration
(> 11.1 mmol/l)
- Fasting plasma glucose concentration
(> 7.0 mmol/l)
- Oral glucose tolerance test (OGTT) with 2 hour plasma glucose concentration > 11.1 mmol/l 2 hours after giving 75g glucose

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16
Q

List some symptoms in which patients with undiagnosed diabetes may present to GP

A
  • Peeing a lot
  • Excessive thirst
  • Weight loss

Plus:
- Blurring of vision
- Frequent infections e.g. thrush
- Tiredness / lethargy / weakness

May also present acutely with symptoms of DKA:
- Reduced consciousness
- Abdominal pain
- Nausea and vomiting
- Pear drop breath
- Polydipsia / polyuria

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17
Q

Describe briefly what diabetes is, as if you were explaining it to a patient

A

Diabetes is a condition where the body is unable to regulate it’s own levels of sugar in the blood due to problems with insulin

Type 1 - can’t produce the insulin in the pancreas because it’s attacked by the body’s immune system

Type 2 - the cells of the body don’t respond to the insulin being produced

If left unmanaged, lots of complications can occur as a result of diabetes

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18
Q

Are there any screening programmes for T1DM and T2DM?

A

T1DM - no screening, based on presentation

T2DM - no screening, however NHS Diabetes Prevention Programme (DPP) identifies people with modifiable risk factors and non-diabetic hyperglycaemia (HbA1c 42 - 47 mmol/mol or 6 - 6.4%)

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19
Q

Outline the monitoring required for T1DM patients, including target HbA1c

A

Measure HbA1c levels at least:
- Every 3 months if < 18 yrs
- Every 3 to 6 months if adults
Target HbA1c = < 48 mmol/mol or < 6.5%
Requires regular monitoring of blood glucose (< 53 mmol/mol or < 7.0 %)

12 monthly:
- Thyroid function tests
- Diabetic eye screen (opticians)
- Urine ACR and eGFR
- Foot checks
- Review cardiovascular risk factors e.g. calculate BMI and BP

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20
Q

Outline the monitoring required for T2DM patients, including target HbA1c

A

Measure HbA1c levels at least:
- Every 3 to 6 months if things aren’t stable
- Every 6 months if stable
Target HbA1c = < 48 mmol/mol or < 6.5%, slightly less if on hypoglycemic risk medication
Only requires regular monitoring of blood glucose if on insulin treatment

12 monthly:
- Diabetic eye screen (opticians)
- Foot checks
- Urine ACR / eGFR
- Review cardiovascular risk factors e.g. blood pressure
- Bloods for lipid profile

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21
Q

Outline the role of structured education programme ‘DESMOND’ in diabetes

A

DESMOND = Diabetes Education and Self Management for Ongoing and Newly Diagnosed

  • Run a range of group-based and online programmes
  • Support for self-management for people who are at risk of developing or currently diagnosed with type 2 diabetes
22
Q

Outline the role of structured education programme ‘DAFNE’ in diabetes

A

DAFNE = Dose Adjustment For Normal Eating

  • Help adults with type 1 diabetes lead as normal a life as possible, whilst also maintaining blood glucose levels within healthy targets
  • Aims to reduce the risk of long-term diabetes complications
23
Q

Outline the main mechanism of action of Biguanides e.g. Metformin

A

Inhibits hepatic glucose production
- Stops new glucose from being produced
- Stops breakdown of glycogen

24
Q

Outline the main mechanism of action of Sulfonylureas e.g. Gliclazide

A

Inhibits K+ channels in the pancreas
- Causes the pancreas to make more insulin

  • However, requires working pancreas *
25
Q

Outline the main mechanism of action of Thiazolidinediones e.g. Pioglitazone

A

Activates PPAR-gamma
- Increases peripheral sensitivity to insulin (in muscle and fat tissues)

26
Q

Outline the main mechanism of action of SGLT-2 inhibitors e.g. Dapagliflozin

A

Inhibits SGLT-2 transporters in kidneys
- More glucose is lost into the urine

27
Q

Outline the main mechanism of action of DPP-4 inhibitors e.g. Sitagliptin

A

Inhibits breakdown of DPP4 enzyme in blood
- So less GLP-1 broken down
- More GLP-1, means less glucose produced by the liver, more insulin production

28
Q

Outline the main mechanism of action of incretin mimetics (tides) e.g. Exenatide or Liraglutide

A

Analogue of GLP-1
- So effectively more GLP-1
- More GLP-1, means less glucose produced by the liver, more insulin production

29
Q

List some contraindications and cautions for use of Biguanides e.g. Metformin

A

Contraindications:
- Metabolic acidosis e.g. ketoacidosis

Cautions:
- eGFR < 30

30
Q

List some side effects for use of Biguanides e.g. Metformin

A
  • GI disturbance e.g. abdominal pain, nausea, bloating, and diarrhoea
  • Lactic acidosis
  • Skin rash
  • B12 deficiency
  • Loss of appetite
  • Metallic taste
  • Hypoglycaemia (uncommon but more likely if taken with sulfonylurea or alcohol)
  • Hepatitis
31
Q

List some contraindications and cautions for use of Sulfonylureas e.g. Gliclazide

A

Contraindications:
- Metabolic acidosis e.g. ketoacidosis

Cautions:
- G6PD deficiency
- Elderly
- Obese

32
Q

List some side effects for use of Sulfonylureas e.g. Gliclazide

A
  • Hypoglycaemia
  • Nausea
  • Skin rash
33
Q

List some contraindications and cautions for use of Thiazolidinediones (glitazones) e.g. Pioglitazone

A

Contraindications:
- Metabolic acidosis e.g. ketoacidosis
- Heart failure
- Previous / active bladder cancer

Cautions:
- Use alongside insulin (risk of heart failure)
- Elderly

34
Q

List some side effects for use of Thiazolidinediones (glitazones) e.g. Pioglitazone

A

Hypoglycaemia!

  • Water retention
  • Numbness
  • Chest infections
  • Skin rashes
  • Worsening of osteoporosis and bone fractures
35
Q

List some contraindications and cautions for use of SGLT-2 inhibitors (gliflozins) e.g. Dapagliflozin or Empagliflozin

A

Contraindications:
- Metabolic acidosis e.g. ketoacidosis

Cautions:
- Hypotension
- Elderly

36
Q

List some side effects for use of SGLT-2 inhibitors (gliflozins) e.g. Dapagliflozin or Empagliflozin

A
  • Hypoglycaemia / DKA
  • Thrush / UTIs
  • Polydipsia / polyuria
  • Postural hypotension
  • Constipation
37
Q

State a caution for use of DPP4 inhibitors (gliptins) e.g. Sitagliptin

A

Previous pancreatitis

38
Q

List some side effects for use of DPP4 inhibitors (gliptins) e.g. Sitagliptin

A
  • Gastrointestinal disturbances e.g. constipation or diarrhoea, N&V
  • Acute pancreatitis (uncommon but severe)
  • Skin rash
  • Headache
  • Dizziness
  • Tremor
  • Muscle aches, joint pain and swelling
39
Q

List some contraindications and cautions for use of incretin mimetics (tides) e.g. Exenatide and Liraglutide

A

Contraindications:
- Metabolic acidosis e.g. ketoacidosis
- Severe GI disease

Cautions:
- Pancreatitis
- Elderly
- Low BMI - may cause loss > 1.5 kg weekly

40
Q

List some side effects for use of incretin mimetics (tides) e.g. Exenatide and Liraglutide

A
  • Gastrointestinal disturbances e.g. constipation or diarrhoea, N&V, GI discomfort
  • Inflammation at injection site
  • Decreased appetite
  • Headache
  • Skin reactions
  • Weakness
41
Q

Outline the different classes of diabetes drugs that can be used in the management of diabetes

A

1st line = Biguanides e.g. Metformin
2nd line = Sulfonylureas e.g. Gliclazide

Other options:
- Thiazolidinediones (glitazones) e.g. Pioglitazone
- SGLT-2 inhibitors (gliflozins) e.g. Dapagliflozin
- DPP-4 inhibitors (gliptins) e.g. Sitagliptin
- Incretin mimetics (tides) e.g. Exenatide

42
Q

Outline how you go about managing someone with non-diabetic hyperglycaemia (pre-diabetes)

A
  • Refer to the national NHS diabetes prevention programme (for lifestyle changes)
  • Yearly blood tests to monitor HbA1c
43
Q

Outline the general conservative management steps for T1DM

A
  • Ensure care plan is in place
  • Offer a structured education programme e.g. DAFNE programme
  • Ensure they are set up with contacts to the diabetes specialist team (including how to contact and how often)
  • Provide information on diabetes support groups
  • Manage lifestyle issues, such as diet, exercise, and alcohol intake
  • Monitor for complications regularly
44
Q

Outline what is covered in an individual care plan for T1DM

A

Medical assessment:
- Review potentially confounding diseases and drugs
- Investigate vascular risk factors, such as hypertension
- Check substance use or other factors

Individual factors:
- Understand patient preferences on nutrition and physical activity
- Assess emotional state to determine the appropriate pace of education

45
Q

Outline the medical management steps for T1DM

A
  • Introduce insulin management
  • Advise regular blood monitoring up to 10 times per day (or continuous with libre device)
  • Continue to monitor for diabetic complications
46
Q

Outline the advice/support for lifestyle factors in type 1 diabetes for:
- Alcohol
- Smoking
- Diet
- Exercise

A

Alcohol:
- Avoid drinking on an empty stomach
- Warn about similarity of being drunk and hypoglycaemia

Smoking:
- Advise against smoking / promote smoking cessation

Diet:
- Should have healthy diet to manage CVS risk
- Offer carbohydrate-counting training
- Can refer to the specialist diabetes team

Exercise:
- Warn about risk of hypoglycaemia
- Regular exercise to manage CVS risk

47
Q

Outline the general management steps for T2DM (non-pharmacological)

A
  • Ensure care plan is in place
  • Offer a structured education programme e.g. DESMOND programme
  • Ensure they are set up with contacts to the diabetes specialist team (including how to contact and how often)
  • Provide information on diabetes support groups
  • Manage lifestyle issues, such as diet, exercise, and alcohol intake
  • Offer immunization against influenza and pneumococcal
  • Advise about entitlement to free NHS prescriptions
  • Monitor for complications regularly
48
Q

Outline the medical management steps for T2DM

A

1st line - Metformin (monitor renal function)
- Consider additional drug therapy
- Assess the person’s cardiovascular status
- Regularly monitor for complications and HbA1c
2nd line - Sulphonylureas e.g. Gliclazide
3rd line - add additional oral hypoglycaemics

49
Q

Outline the advice/support for lifestyle factors in type 2 diabetes for:
- Alcohol
- Smoking
- Diet
- Exercise

A

Alcohol:
- Avoid drinking on an empty stomach
- Alcohol and some drugs may increase the hypoglycaemic effects of some drugs e.g. Gliclazide

Smoking:
- Advise against smoking / promote smoking cessation

Diet:
- Should have healthy diet to manage CVS risk
- Advise to aim for weight loss if possible

Exercise:
- Regular exercise to manage CVS risk
- Minimize time spent being sedentary

50
Q

State the 5 stages of grief

A

Denial
Anger
Bargaining
Depression
Acceptance