Weeks 12-15 Drug Names Flashcards
(130 cards)
1
Q
Somatropin MOA
A
synthetic growth hormone… aides bone, skeletal muscle, and organ growth
2
Q
Somatropin AE
A
edema and muscle/joint pain
3
Q
Somatropin Class and Indication
A
Synthetic GH… Hypopituitarism
4
Q
Vasopressin (DDAVP) MOA
A
makes water channels in kidney more permeale so = water retention
5
Q
Vasopressin (DDAVP) AE
A
dry mouth and hyponatremua
6
Q
Vasopressin (DDAVP) Class and Indication
A
Synthetic ADH so… Hypopituitarism and Nocturia
7
Q
Spironolactone MOA
A
non-selective aldosterone receptor antagonist
8
Q
Spironolactone AE
A
More than Eplerenone… dehyrdration and electrolyte imbalance
9
Q
Sprionolactone Class and Indication
A
Diuretic… hyperaldosteronism (mineralcorticoid excess)
10
Q
Eplerenone MOA
A
Selective aldosterone receptor antagonist
11
Q
Eplerenone AE
A
less than spironolactone due to selective… but still dehydration and electrolyte imbalance
12
Q
Eplerenone Class and Indication
A
Diuretic… Hyperaldosteronism (mineralcorticoid excess)
13
Q
Hydrocortisone MOA
A
replacement for cortisol (glucocorticoid)
14
Q
Hydrocortisone AE
A
short term: edema and hyperglycemia
long term: osteoporosis and poor wound healing
15
Q
Hydrocortisone Class and Indication
A
Synthetic Cortisol… glucocorticoid deficiency
16
Q
Fludrocortisone MOA
A
replacement for aldosterone (mineralcorticoid)
17
Q
Fludrocortisone AE
A
frequent urination and hypotension
18
Q
Fludrocortisone Class and Indication
A
Synthetic Aldosterone… hypoaldosteronism = mineralcorticoid deficiency
19
Q
Testosterone AE
A
basically whole body problems, but definitely cardiovascular problems, hepatotoxicity, and decrease spermatogenesis
20
Q
Mirabegron MOA
A
relaxes detrusor muscle to increase voiding
21
Q
Mirabegron AE
A
increase BP
22
Q
Mirabegron Class and Indication
A
B-3 Adrenergic Agonist for BPH
23
Q
Oxybutynin MOA
A
blocks ACh on SM to relax muscle
24
Q
Oxybutynin AE
A
anticholinergic effects (blurry vision, dry mouth, and constipation)
25
Oxybutynin Class and Indication
Anticholinergic Agent... BPH
26
Levothyroxine MOA
synthetic thyroxine which turns to T3
27
Levothyroxine AE
NTI drug requires monitoring... tachycardia can occur
28
Levothyroxine Class and Indication
Synthetic Thyroxine... hypothyroidism
29
Methimazole MOA
blocks T4 to T3 to aide in hyperthyroidism
30
Methimazole AE
Gi Upset due to more metabolic effects due to hyperthyroidism
31
Methimazole Class and Indication
Anti-Thyroid... for hyperthyroidism
32
Calcium MOA
helps body create bone efficiently
33
Calcium AE
GI and constipation
34
Calcium Class and Indication
Mineral... osteoporosis
35
Vitamin D MOA
aides in calcium breakdown for bone health
36
Vitamin D AE
GI and constipation
37
Vitamin D Class and Indication
Vitamin... osteoporosis
38
Metformin MOA
inhibits glucose production and increases insulin sensitivity
39
Metformin AE
lower risk of hypoglycemia... GI upset
40
Metformin Class and Indication
Antihyperglycemic Drug for Type II Diabetes
41
Glipizide MOA
binds to sulfonylurea receptors to cause insulin release
42
Glipizide AE
hypoglycemia
43
Glipizide Class and Indication
Sulfonylurea... antihyperglycemic drug
44
Adderall MOA
blocks dopamine and NE reuptake... increases dopamine and NE release
45
Adderall AE
decrease appetite and weight loss... zombie-like states
46
Adderall Class and Indication
Stimulant Medication for ADHD
47
Methylphenidate (Ritalin) Class and Indication
Stimulant Medication for ADHD
48
Methylphenidate (Ritalin) MOA
blocks dopamine and NE reuptake = increase dopamine and NE release
49
Methylphenidate (Ritalin) AE
decrease appetite and weight loss... zombie-like states
50
Atomoxetine (Strattera) Class and Indication
Selective NE Reuptake Inhibitor (SNRI) for ADHD
51
Atomoxetine (Strattera) MOA
blocks NE reuptake = more NE in post-synaptic cleft
52
Atomoxetine (Strattera) AE
decrease appetite, weight loss, zombie-like states AND more fatigue/sedation
53
Levodopa-Carbidopa (Sinemet) Class and Indication
Dopamine Replacement for PD
54
Levodopa-Carbidopa (Sinemet) MOA
adds more dopamine and inhibits breakdown of L-Dopa before it crosses BBB
55
Levodopa-Carbidopa (Sinemet) AE
dosing on's and off's... freezing and involuntary movements
56
Requip Class and Indication
Dopamine Agonist for PD
57
Requip MOA
agonist for dopamine receptors
58
Requip AE
Orthostatic Hypotension
59
Interferon B Class and Indication
DMT for MS
60
Interferon B MOA
immune function impact
61
Interferon B AE
flu-like symptoms
62
Glatiramer Acetate Class and Indication
DMT: Biologic Agent for MS
63
Glatiramer Acetate MOA
reduces autoimmune response to myelin
64
Glatiramer Acetate AE
injection site reaction
65
Fingolimod Class and Indication
S1P Receptor Modulator for MS
66
Fingolimod MOA
decreases inflammatory response
67
Fingolimod AE
headaches, infection, macula degeneration
68
Dimethyl Fumarate Class and Indication
Fumaric Acid Derivative for MS
69
Dimethyl Fumarate MOA
anti-inflammatory properties
70
Dimethyl Fumarate AE
GI problems
71
"-mab" Class and Indication
Monoclonal Antibodies for MS
72
"-mab" MOA
antibodies that help decrease inflammation in CNS
73
"-mab" AE
headaches and injection site reactions
74
Tizanidine Class and Indication
Alpha 2 Agonist for Muscle Spasms
75
Tizanidine MOA
binds to Alpha 2 receptors to decrease excitability
76
Tizanidine AE
drowsiness, dizziness and sedation
77
Flexeril Class and Indication
Centrally Acting Antispasmodic for Muscle Spasms
78
Flexeril AE
sedation and dizziness
79
Baclofen Class and Indication
Direct Acting Agent for MS Spasticity
80
Baclofen MOA
inhibitory effects DIRECTLY onto alpha motor neurons to decrease excitability = decrease spasticity
81
Baclofen AE
BOXED WARNING: intrathecal baclofen CNS depressant (sedation)
82
Botox Indication
Spasticity
83
Botox MOA
blocks ACh release = less spasticity
84
Botox AE
injection site reaction
85
Donepezil (Aricept) Class and Indication
Cholinesterase Inhibitor for AD
86
Donepezil (Aricept) MOA
increases ACh by inhibiting it's breakdown
87
Donepezil (Aricept) AE
cholinergic effects such as SLUDGE
88
Memantine (Namenda) Class and Indication
NMDA Antagonist for AD
89
Memantine (Namenda) MOA
antagonizes NMDA receptor which stops glutamate = decrease excitation
90
Memantine (Namenda) AE
confusion and dizziness
91
Celexa Class and Indication
Selective Serotonin Reuptake Inhibitor (SSRI) for Depression
92
Celexa MOA
inhibits the reuptake of serotonin in CNS = more serotonin
93
Celexa AE
better than SNRI's, but still headaches and GI problems
94
Lexapro Class and Indication
SSRI and Depression
95
Lexapro MOA
inhibits serotonin reuptake = more serotonin
96
Lexapro AE
better than SNRI's, but still headaches and GI problems
97
Effexor Class and Indication
Serotonin/Norepineprhine Reuptake Inhibitor (SNRI) and Depression
98
Effexor MOA
inhibits both serotonin and NE reuptake = more serotonin and NE
99
Effexor AE
worse than SSRI's, headaches and GI problems
100
Cymbalta Class and Indication
SNRI and Depression
101
Cymbalta MOA
inhibits both serotonin and NE reuptake = more serotonin and NE
102
Cymbalta AE
worse than SSRI's, headaches and GI problems
103
Bupropion (Wellbutrin) Class and Indication
DA/NE Reuptake Inhibitor for Depression... helps with reducing sexual dysfunction
104
Bupropion (Wellbutrin) MOA
inhibits NE and DA reuptake = more NE and DA
105
Bupriopion (Wellbutrin) AE
headaches and GI problems
106
Xanax Class and Indication
Benzodiazepine and Anxiety
107
Xanax MOA
binds to GABA to increase inhibitory effects
108
Xanax AE
sedation and ataxia (impaired balance and movement)... fall risk
109
Buspirone (Buspar) Class and Indication
anti-anxiety for anxiety
110
Buspirone (Buspar) MOA
binds to serotonin and dopamine receptors to decrease anxiety
111
Buspirone (Buspar) AE
dizziness and potential reflex anxiety... fall risk
112
Seroquel Class and Indication
SGA for Schizophrenia
113
Seroquel MOA
blocks D2 receptors but less than FGA... more serotonin affinity
114
Seroquel AE
neuromuscular effects such as tardive dyskinesia (involuntary movements)
115
Lithium Indication
Bipolar
116
Lithium MOA
prevention and management of acute manic episodes
117
Lithium AE
LOTS OF THEM... GI problems, weight gain and CNS problems
118
Lithium Special Considerations
requires frequent plasma concentration monitoring due to BOXED WARNING toxicity
119
TZD's (Thiazolidinedione) Indication
Diabetes Mellitus
120
TZD's (Thiazolidinedione) MOA
the same as metformin... increases insulin sensitivity... called the "insulin sensitizer" drugs
121
TZD's AE
low hypoglycemia risk but females have an increase in bone fracture
122
DPP-4 Inhibitor Indication
Diabetes Mellitus
123
DPP-4 Inhibitor MOA
increase in insulin synthesis and release and a decrease in glucagon secretion = helps with hyperglycemia
124
DPP-4 Inhibitor AE
low risk of hypoglycemia but can result in arthralgia (joint pain)
125
SGLT2 Inhibitor Indication
Diabetes Mellitus
126
SGLT2 Inhibitor MOA
blocks glucose reabsorption in kidney = increase urinary glucose excretion for hyperglycemia
127
SGLT2 Inhibitor AE
renal insufficiency due to increase output... also "Canagliflozin: increase risk of bone fracture and foot infections"
128
GLP1 Receptor Agonist Indication
Diabetes Mellitus
129
GLP1 Receptor Agonist MOA
basically it resembles glucagon and therefore increases insulin and decreases glucose = for hyperglycemia
130
GLP1 Receptor Agonist AE
GI problems
