Flashcards in What is pharmacology? Deck (16):
The study of the effects of drugs on biological systems
Study of the molecular, biochemical, and physiological effects of drugs on cellular/body systems and their mechanisms of action
Study of the absorption, distribution, and elimination of drugs
The study of genetic influences on the effectiveness and fate of drugs
The study of the adverse or toxic effects of drugs and other chemical agents
Where do drugs come from?
3. Endogenous compounds
4. Modification of endogenous compounds
5. Synthetic chemicals
Give examples of extracts from plants and herbs and what are they used for?
Opium poppy- Morphine(pain killer)
Foxglove- digitalis(digoxin)- used to treat congestive heart failure
Give examples of drugs from microorganisms?
Penicillin(antibiotic), penicillin interferes with bacterial cell walls.
Give examples of endogenous compounds?
-Insulin(to treat diabetes)
-Thyroxine(treatment of thyroid insufficiency)
-Growth hormone(treatment of short stature)
Give examples of chemical modification of hormones/endogenous compounds?
-Ethinyl estradiol (readily absorbed form of oestrogen)
-6-mercaptopurine and 6-thioguanine- modified base components of DNA/RNA-interfere with DNA/RNA synthesis
Give examples of chemical synthesis?
-Indomethacin,celecoxib- COX inhibitors(NSAIDS)
-Cimetidine-histamine receptor modulator
-Simvastatin-HMG-CoA reductase inhibitor
What are the names of drugs discovered by chance?
-Antidepressants= monoamine oxidase inhibitors and tricyclic antidepressants
-Cisplatin-platinum containing drug used to treat a number of cancers.
What are generic names?
Related to the composition, structure, source of the drug. Preferred name for general use. Often have similar endings that give some insight into the class of drug eg celecoxib, rofecoxib, etoricoxib etc
What are brand names?
Drug company's name for the drug
What are the protein targets of drugs?
3. Ion channels
4. Carrier molecules