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Flashcards in White Blood Cell Quiz Deck (36):
1

  • Pro-lymphocytes (mitotically active) aggregate together forming proliferation centers
  • Smudge Celll
  • CD19, 20, 23, and 5 (T-cell marker)
  • Location: Blood and marrow

CLL

2

  • Pro-lymphocytes (mitotically active) aggregate together forming proliferation centers
  • Smudge Celll
  • CD19, 20, 23, and 5 (T-cell marker)
  • Location: Lymph nodes

SLL

3

  • CD10, 18, 22, and TdT
  • Invade bone marrow
  • t(9;22) or (12;21)

Precursor B cell ALL

4

  • CD3, 7, and TdT
  • Thymic tumor
  • t(9;22) or (12;21)

Pre T cell ALL

5

  • Nodular pattern of infiltration of tissue
  • sIg, CD 19, 20, and CD79a (CD5 is not expressed)

  • Stain for bcl-2 is (+)

  • T(14;18)

Follicular Lymphoma

6

  • CD19, 20, 22, 79a, sIg
  • Cells overexpress bcl-6
  • Large cells

Diffuse Large B cell Lymphoma

7

  • CD10, 19, 20, 22, 79a, sIg, and bcl-6
  • Translocation involves c-myc on chromosome 8
  • Marophages with ingested debris
  • Small cells

Burkitt Lymphoma

8

  • Mott cell (perinuclear clearning)
  • cIg (+)
  • Punched out bone lesions

Multiple Myeloma

9

  • CD19, 20, 22, 79a, surface IgM
  • NOT CD5 or CD23 (distinguishes from B-CLL)
  • Intranuclear inclusion, IgM
  • Secretes M protein
  • NO L-chains

Lymphoplasmacytic Lymphoma

10

  • Resemble normal B cells
  • CD5, 19, 20, 22 and sIg (IgM)
  • NO CD10 or 23 
  • Over expression of cyclin D1 
  • Painless lymphadenopathy

Mantle Cell Lymphoma

11

  • CD19, 20, 22, 79a, sIgM
  • Associated with H. pylori infxn

Extranodal Marginal Cell Lymphoma

12

  • CD19, 20, 22, 79a, sIgM
  • Replaces white pulp germinal centers

Splenic Marginal cell lymphoma

13

  • Thin membrane protrusions (looks like hair)
  • CD103
  • Marrow fibrosis
  • Massive splenomegaly and pancytopenia

Hairy Cell Leukemia

14

  • CD4, 30
  • Anaplastic lymphoma kinase
  • Infiltration of dermis and generalized lymphadenopathy

Anaplastic Large Cell Lymphoma

15

  • HTLV-1 Provirus Positive
  • CD2, 3, 5
  • Hyperlobated nuclei
  • Bone and cutaneous lesions

Adult T cell Leukemia / Lymphoma

16

  • CD4, 2, 3, 45RO, 5
  • Cells form bands thru tissue
  • Symptoms
    • Inflammatory preneoplastic phase: like eczema
    • Plaque phase
    • Tumor phase: with ulcerations

Mycosis Fungoides

17

  • CD4, 2, 3, 45RO, 5
  • cell with cerebriform shaped nucleus
  • Erythroderma
  • Lymphadenopathy

Seazary Syndrome

18

  • TCR, CD3, CD8
  • Lymphocytosis
  • Anemia
  • Neutropenia

T cell variant Large Granular Lymphocytic Leukemia

19

  • CD56
  • B symptoms
  • Hepatosplenomegaly
  • Anemia / Thrombocytopenia

NK cell variant Large Granular Lymphocytic Leukemia

20

  • CD2 and CD56
  • Associated with EBV
  • Invade small vessels
  • ischemic necrosis
  • Most commonly affects nose and sinuses

Extranodal NK / T cell Lymphoma

21

  • HRS Lacunar cells
  • CD15+, CD30+, EBV-, CD20-
  • Bands of collagen divide tissue into nodules

Nodular Sclerosis Hodgkins Lymphoma

Presents in Stage 1 or 2

22

  • Classic HRS and Mononuclear variants
  • CD15+, CD30+, EBV+

Mixed Cellular HL

Presents in stage 3 or 4

23

  • Classic HRS cell and Mononuclear variants
  • CD15+, CD30+
  • 40% EBV+
  • Infiltrate mostly T cells

Lymphocyte Rich HL

24

  • Hypocellular infiltrate
  • CD15+, CD30+, EBV+
  • Non-collagenous fibrosis

Lymphocyte Depletion HL

Presents in Stage 3 or 4

25

  • Popcorn cell
  • CD20+
  • Able to produce Ig 
  • Inguinal node involvement
  • Inflammatory infiltrate mostly B cells

Nodular Lymphocyte Predominant HL

Presents in stage 1 or 2

26

  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with clear cytoplasm

AML, M1

27

  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with fine, azurophilic peroxidase positive granules

AML, M2

28

  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with Hypergranular, azurophilic peroxidase positive granules and Auer rods

AML, M3

29

  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large nucleus with basophilic granules in cytoplasm

AML, M4

30

  • Myeloid blasts > 20% of bone marrow cells
  • CD34, 33, some with CD15
  • large, folded or lobulated nucleus
  • Peroxidase negative
  • Esterase positive

AML, M5

31

  • Circulating neutrophils, metamyelocytes, and myelocytes
  • Marrow is ~100% cellular
  • bcr-abl fusion gene

CML

32

  • Hypercellular bone marrow
  • erythrocytosis, granulocytosis, and thrombocytosis in periphery
  • Increased red cell mass and hematocrit
  • Low lvls of EPO
  • Erythromelalgia

Polycythemia Vera

33

  • Thrombocytosis with giant platelets
  • Erythromelalgia
  • Characteristics of other myeloproliferative diseases are absent

Essential thrombocytosis

Must be diagnosed by excluding other diseases

34

  • Marrow fibrosis
  • In marrow, megakaryocytes are large and clustered
  • Peripheral blood shows nucleated erythroid progenitors, granulocytic progenitors, and teardrop shaped RBCs

Primary Myelofibrosis

Marrow converted to bone late in disease

35

  • Cells express CD1, S-100, HLA-DR
  • Birbeck granules with areas of dilation

Langerhans cell histiocytosis

36

What is the Hand Schuller Christian triad?

  • In Langerhans Cell Histiocytosis
    • Diabetes insipidus
    • Exophthalmos
    • Involvement of calvaria