Women's Health

Question 1

Parity

Answer 1

of deliveries after 20 weeks

Question 2

Gravida

Answer 2

of pregnancies

Question 3

Abortus

Answer 3

of miscarriages/abortions

Question 4

1st trimester

Answer 4

week 1 to end of week 13

Question 5

2nd trimester

Answer 5

week 14 to end of week 26

Question 6

3rd trimester

Answer 6

week 27 until birth

Question 7

When is day 1 of pregnancy?

Answer 7

First day of last menstrual cycle

Question 8

Main Embryonic Period

Answer 8

weeks 5 to 10

Question 9

Fetal Period

Answer 9

weeks 11 to birth

Question 10

Exposure at week 3-4

Answer 10

All or none effect - spontaneous abortion most common

Question 11

Exposure at week 5-10

Answer 11

major congenital anomalies

Question 12

Exposure at week 11-birth

Answer 12

functional defects and minor anomalies

Question 13

When is organogenesis

Answer 13

weeks 5-11

Question 14

Folic Acid dose for women of reproductive age

Answer 14

0.4 - 0.9 mg

Question 15

Folic Acid dose for women of reproductive age on Anti Epileptic drugs

Answer 15

4 mg

Question 16

Pregnancy Category A

Answer 16

controlled studies show no risk

Question 17

Pregnancy Category B

Answer 17

no evidence of risk in humans OR if no human studies, animal studies show no risk

Question 18

Pregnancy Category C

Answer 18

risk cannot be ruled out - no good human studies and animal studies show risk or there are no animal studies

Question 19

Pregnancy Category D

Answer 19

studies have shown fetal risk but benefits could outweigh the risks

Question 20

Pregnancy Category X

Answer 20

studies have shown fetal risk and risks would outweigh benefits

Question 21

What makes for a good drug to cross the placenta?

Answer 21

high lipophilicity
MW <500 daltons
unbound (low protein binding) – switches as pregnancy progresses
weak bases

Question 22

Hypertension medications in pregnancy

Answer 22

Labetalol, Nifedipine, Methyldopa

Question 23

N/V treatment in pregnancy

Answer 23

Doxylamine + B6
Metoclopramide
Ondansetron

Question 24

Labor Induction using

Answer 24

prostaglandins or oxytocin

Question 25

Infant suckling causes release of what?

Answer 25

prolactin and oxytocin

Question 26

Prolactin

Answer 26

causes alveoli to take nutrients from the blood and turn them into breast milk

Question 27

Oxytocin in lactation

Answer 27

causes the cells around the alveoli to contract and eject milk down the milk ducts (let-down)

Question 28

Colostrum

Answer 28

first 3 days of breast feeding

Question 29

Mature milk

Answer 29

3 - 5 days after birth

Question 30

Foremilk

Answer 30

first receives while breast feeding, thin watery

Question 31

Hind-milk

Answer 31

released after several minutes of nursing, highest concentration of fat

Question 32

What makes for a good drug to cross into breast milk?

Answer 32

``` low protein bound low MW <500 Daltons High lipid solubility high concentration longer half lives weak bases ```

Question 33

Safe RID

Answer 33

<10%

Question 34

Unsafe RID

Answer 34

>25%

Question 35

RID formula

Answer 35

``` Infant dose (mg/kg/day) --------------------------------------- maternal dose (mg/kg/day) ```

Question 36

Breast milk intake if unknown

Answer 36

150 ml/kg

Question 37

Use systemic hormone therapy when...

Answer 37

moderate to severe VSM +/- GSM

Question 38

Use intravaginal hormone therapy when...

Answer 38

moderate to severe symptoms of GSM

Question 39

Continuous Cyclic HT

Answer 39

E daily, P last 12-14 days | Scheduled withdrawal bleed

Question 40

Continuous Combined HT

Answer 40

E + P daily | reserved for women 2 years post menopause

Question 41

Continuous Long Cycle HT

Answer 41

E daily, P last 12-14 days every other cycle

Question 42

Intermittent Combined HT

Answer 42

3 days of E alone then 3 days of E + P | repeat without interruption

Question 43

Testosterone treats

Answer 43

decreased sexual desire (no help with VMS)

Question 44

Raloxifene treats

Answer 44

OP (worsen VMS)

Question 45

Ospemifene (Osphena) treats

Answer 45

severe dyspareunia

Question 46

CEE + Bazedoxifene (Duavee) treats

Answer 46

moderate/severe VSM without hysterectomy

Question 47

Paroxetine treats

Answer 47

VSM (+depression)

Question 48

Desevelafaxine treats

Answer 48

VSM (+depression)

Question 49

Clonidine treats

Answer 49

VSM