Women's Health Drugs Flashcards

(43 cards)

1
Q

What is Endogenous Estrogen used for?

A

Menopausal hormone therapy (HT)

Female hypogonadism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is Endogenous Progestin used for?

A

Menopausal hormone therapy (HT)

Dysfunctional uterine bleeding or amenorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What two cancers can Endogenous Estrogen lead to?

A

Endometrial hyperplasia → endometrial Cancer

Breast Cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are Selective estrogen receptor modulators (SERMs) used for?

A

Menopause Hormone Therapy (HT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What 3 drugs are in the Selective estrogen receptor modulators (SERMs) class?

A

Tamoxifene
Raloxifene
Bazedoxifene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What do Selective estrogen receptor modulators (SERMs) do?

A

Agonize estrogen receptors in some cells & block them in others

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

3 adverse effects of Selective estrogen receptor modulators (SERMs)

A

Increases endometrial cancer risk

Increases hot flashes

Increases thromboembolism risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What do Combination oral contraceptives do??

A

Inhibit ovulation via FSH suppression (estrogen negative feedback)

The follicle cannot mature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is a “mini-pill”?

A

Progestin-only oral contraceptive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does a Progestin-only oral contraceptive do?

A

Changes cervical secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the major for a Subdermal etonogestrel implant to be used?

A

irregular vaginal bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does Depot medroxyprogesterone acetate do?

A

inhibition of FSH/LH secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which oral contraceptive has a black box warnign & why?

A

Depot medroxyprogesterone acetate because of bone loss risk

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does a cooper IUD stop sperm from getting you prego?

A

Local foreign body rxn & chemical changes toxic to sperm

zaps those fuckers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How does a Levonorgestrel IUD keep you from getting prego?

A

thickens cervical mucus, inhibit ovulation, alter the endometrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is misoprostol used for?

A

Termination of early intrauterine pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How does misoprostol work?

A

blockade of progesterone receptors → expulsion of conceptus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What 3 drugs for follicular maturation?

A

Clomiphene, Menotropin & Follitropin

19
Q

Which two follicular maturation drugs require hCG to induce ovulation?

A

Menotropin & Follitropin

20
Q

What is hCG & choriogonadotropin alfa used for?

A

Facilitate ovulation

21
Q

What are the two big adverse effects of hCG & choriogonadotropin alfa?

A

Ovarian hyperstimulation syndrome

Ruptured of ovarian cyst

22
Q

What are the 5 tocolytic drug classes?

A

B2 agonists

Calcium channel blocker

COX inhibitors

Oxytocin receptor blockers

Magnesium sulfate

23
Q

What are tocolytic drugs used for?

A

Suppresses labor that has already started

24
Q

What B2 agonist drug is a tocolytic?

25
How does terbutaline work?
Agonize B2 on uterine smooth muscle → decreased uterine contraction
26
4 adverse effects of terbutaline
Pulmonary edema Hypotension Hyperglycemia Tachycardia
27
What COX inhibitor is | a tocolytic drug?
indomethacin
28
how does indomethacin work?
Inhibits synthesis of prostaglandins → decreased uterine contractions via cAMP-mediated pathway
29
What effect can indomethacin have on a fetus when given in high doses?
Can precipitate premature narrowing/closure of ductus arteriosus in high doses
30
How Magnesium sulfate | work?
Inhibits ACh at the neuromuscular junction
31
If a laboring mom is given Magnesium sulfate what should you be ready to do for the baby??
supporting the respiratory function of the newborn with mechanical ventilation
32
What is Hydroxyprofesterase caproate used for?
Prevent preterm labor
33
What are the 2 drugs for cervical ripening?
Dinoprostone & Misoprostol
34
What are 2 adverse effects of Dinoprostone & Misoprostol?
Tachysystole (high rate of uterine contractions) Systemic absorption → N/V, diarrhea, fever
35
What is Oxytocin (Pitocin) used for?
Stimulate uterine contractions Increased force, frequency, & duration of contractions → receptors increase in number as labor progresses
36
You should only give Oxytocin (Pitocin) if what 2 things are ready?
if fetal lungs are mature and if the cervix is ripened
37
What are the 4 drugs used for Drugs for Postpartum Hemorrhage?
Oxytocin Misoprostol Hemabate Methylergonovine (Methergen)
38
What Postpartum Hemorrhage drug should you use with caution if patient has asthma?
Hemabate --> because of intense vasoconstriction
39
What Postpartum Hemorrhage drug do you only use for emergencies?
Methylergonovine (Methergen)
40
What Postpartum Hemorrhage drug is a big NO NO if Mom has HTN?
Methylergonovine (Methergen)
41
What is Tranexamic acid (TXA) used for?
Menorrhagia --> decrease bleeding
42
three absolute contraindications of combination oral contraceptives or hormone therapy.
* pregnancy * history of stroke * history of myocardial infarction
43
5 absolute contraindications to oral contraceptives
1. Breast, endometrial CA 2. Acute liver disease 3. Uncontrolled HTN 4. Thrombosis: DVT, MI, CVA 5. Undiagnosed vaginal bleeding