Women's Health OB Flashcards

(67 cards)

1
Q

APGAR SCORE

A

Summary of health of newborn: Done @ 1 and 5 mins after birth (AND EVERY 5 MINS AFTER UNTIL THEY ARE > 7)

→ Appearance:
0: CYANOTIC/mottled
1: Cyanotic extremities/pink body
2: Pink extremities and body

→ Pulse:
0: Absent
1: <100
2: >100

→ Grimace:
0: No response to stimulation
1: Grimace with suction/aggressive stim.
2: Cry on stimulation

→ Activity:
0: None
1: Some flexion of extremities
2: Strong cry

→ Respirations:
0: Absent
1: Weak, irregular, slow
2: Strong cry

**7-10 = Normal
**
4-6 = moderately depressed (needs further eval)
***0-3 = CRITICAL

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2
Q

Fetal Size/Attitude/Lie

A

→ Fetal Size:
Fetal Head = Most Critical
CEPHALOPELVIC DISPROPORTION → LABOR DYSTOCIA (difficult/obstructed)
Macrosomia = Birth weight >90th percentile
Associated with shoulder dystocia (fecal shoulders unable to pass below maternal pubic symphysis)

→ Fetal Attitude:
Full flexion = Chin on chest, rounded back with flexed arms, legs
Smallest diameter of the head at pelvic inlet (suboccipitobregmatic diameter)

→ Fetal Lie:
Relationship of fetal cephalocaudal axis (spinal column) to material cephalocaudal axis
LONGITUDINAL (IDEAL): fetal spine lies alone maternal
TRANSVERSE: fetal spine perpendicular to maternal
OBLIQUE: fetus at slight angle

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3
Q

Fetal Presentation Cephalic

A

Fetal Presentation:
Presenting part of fetus that is entering the pelvic inlet first

** CEPHALIC: HEAD FIRST (ideal)
Vertex = MC/Optimal
Head completely flexed onto chest → occiput (fetal occipital skull) presenting

Brow:
Fetal head partially extended → Sinciput (frontal bone/anterior fontanelle) presenting

Face:
Head hyperextended/ Fetal face from forehead to chin presenting

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4
Q

Fetal Presentation Breech

A

** Breech Birth:
→ Bottom first
Decreases with increased gestational age:
<28 weeks = 25%, but only 3-4% if full term

DX: Physical exam or US confirmation

TX: External Cephalic Version at or near term followed by a TRIAL of a Vaginal Delivery → CSection if failed

** BREECH: Bottom First
Frank Breech:
HIPS flexed, Knees extended, BOTTOM PRESENT

Complete Breech:
Hips & Knees flexed, BOTTOM PRESENT

Incomplete Breech:
One/Both hips not completely flexed, FEET PRESENT

** BREECH: Shoulder First
Transverse lie, SHOULDERS FIRST

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5
Q

Multiple Gestations

A

→ Ex.) 13 weeks + fundal height and alpha-fetoprotein > than expected for due date

Twins = 1/80 Births

→ MONOZYGOTIC = Identical
Multiple fetuses by the splitting of ONE ZYGOTE
→ DIZYGOTIC = Fraternal
Multiple fetuses produced by TWO ZYGOTES
→ POLYZYGOTIC
Multiple fetuses produced by TWO or MORE ZYGOTES

Dx:
→ First Screening:
Greater FUNDAL height than expected
EXTRA fetal heart tones
ELEVATED AFP (alpha-fetoprotein)

Tx:
→ Prenatal visits more frequently
→ Manage diet, surveillance of fetal growth and cervical length

Care:
→ INDUCTION for vaginal or c-section > 34
→ Complications: Spontaneous Abortion, Preeclampsia, anemia

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6
Q

1ST STAGE OF LABOR

A

1st Stage:
Onset of labor to fully dilated (10cm)

Early/Late: 8-12 hrs
Mild contractions every 5-30 mins - Duration ~30 seconds - gradually increase in F, I, D
Cervical Dilated: 0-3 cm
Effacement: 0-30% (cervix stretches and gets thinner)
Spontaneous ROM

Active Phase: 3-5 hrs
Contractions every 3-5 mins - duration >/= 1 min
Cervical Dilation: 3-7cm
Effacement: 80%
Progressive fetal decent

Transition Phase: 30 mins - 2 hrs
Intense contractions every 1.5-2 mins, lasting 60-90 secs
Cervical Dilation 7-10 cm
Effacement: 100%

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7
Q

2ND STAGE OF LABOR

A

Fully dilated to birth infant = PUSH

Navigating through pelvis by 3 Ps:
Power, Passenger, Passage

POWER:
F, D, I of contractions

PASSENGER: BABY
Fetal Size:
Fetal Attitude
Fetal Lie
Fetal Presentation
Cephalic
Breech

PASSAGE:
Route through bony pelvis

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8
Q

SIZE/TYPE of PELVIS: (4)

A

GYNECOID: Optimal
Rounded Pelvic Outlet, midpelvis, adequate outlet capacity

ANDROID: Labor Dystocia = Common
Heart shaped PO, decreased midpelvis diameters

ANTHROPOID:
Oval shaped, favorable midpelvis, adequate outlet capacity

PLATYPELLOID: NOT favorable
Oval shaped, decreased midpelvis

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9
Q

CARDINAL MOVEMENTS/Mechanisms of Labor: (6 STEPS)

A

DESCENT:
Presenting part of fetus reaches pelvic inlet (engagement)
Degree of descent/fetal station, relationship of presenting part to maternal ischial spines
Fetus moved from pelvic inlet (-5 station) down to ischial spines (0 station) to pelvic outlet (+4) to crowning at vaginal opening (+5)

FLEXION:
Fetal chin presses against chest, head meets resistance from pelvic floor

INTERNAL ROTATION:
Fetal shoulders INTERNALLY rotate 45* = widest part of shoulders are in line with the widest part of the pelvis

EXTENSION:
Fetal head passes under symphysis pubis (+4) and moves (+5), emerges from vagina
RESTITUTION/EXT. ROTATION:
Head EXTERNALLY rotates as the shoulders pass through pelvic outlet, under symphysis pubis, turns to align with back

EXPULSION:
Anterior shoulder slips under symphysis pubis, following by posterior shoulder, rest of the body, marks end of second stage

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10
Q

3RD STAGE OF LABOR

A

Delivery of Placenta

Delivery of placenta, umbilical cord, fetal membranes
Uterus contracts firmly
Placenta separates from uterine wall

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11
Q

4TH STAGE OF LABOR

A

Physiological adaptation to blood loss, initiation of uterine involution

Where atony can occur

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12
Q

FETAL MONITORING:

A

Monitoring:
HR and Pattern
Normal HR in newborn: 120-160

Fetal Distress: CONSISTENT DECELERATIONS after a contraction

External Fetal monitor = moms belly
Internal Fetal monitor = electrode on infants head

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13
Q

FETAL HR CHANGES/NST: (4)

A

ACCELERATIONS: increase in baseline by 15 bpm for 15 secs
Response to fetal movement
REASSURING

EARLY DECELERATIONS: Mirror images of contractions
Fetal head is compressed
Benign

VARIABLE DECELERATIONS: Rapid FHR drop WITH A RETURN TO BASELINE
Cord compression
If severe=worrisome (mild/mod = benign)

LATE DECELERATIONS: FHR drop at the END OF A CONTRACTION
UTEROPLACENTAL INSUFFICIENCY
BAD!

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14
Q

Preg. Physiology Changes - Uterus

A

→ UTERUS:
Increase size/capacity: Hypertrophy, Hyperplasia, Stretching (20x larger)
Increase strength, distensibility, contractile proteins, number of mitochondria
Increase volume capacity (10ml → 5L)
HEGAR’S SIGN: softens uterine isthmus

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15
Q

Preg. Physiology Changes - Cervix

A

→ CERVIX:
FORMATION OF MUCUS PLUG: seals endocervical canal
Increased vascularity = Chadwick’s Sign:
PURPLE-BLUE COLOR
Goodell’s Sign: Hyperplasia, softening (increased softening in 3rd trimester)

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16
Q

Preg. Physiology Changes - Placenta

A

Develops where embryo attaches to uterine wall
Covers 50% of internal uterine surface
Maternal-fetal organ for metabolic, nutrient exchange
Secretes ESTROGEN, PROGESTERONE, RELAXIN, HCG

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17
Q

Preg. Physiology Changes - Vagina

A

Increased vascularity: blue-purple color
Loosens connective tissue = increased distensibility
LEUKORRHEA:
pH 3.5-6.0 to protect against bacterial infections

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18
Q

Preg. Physiology Changes - Breast

A

Increased size, weight, nodularity, blood flow, vascular prominence
Areola, nipples are darker due to increased melanocytes
Increased activity of MONTGOMERY TUBERCLES (sebaceous glands)
Estrogen increased growth of lactiferous ducts
Secretion of COLOSTRUM at WEEK 16

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19
Q

Preg Changes - Cards

A

Hypertrophy, S2/S3 = easily heard with exaggerated split

Increased HR by 15-20
Increased SV, CO

Decreased BP (due to progesterone induced vasodilation)

Supine Hypotensive Syndrome:
Caused by gravid uterus pressing on IVC (left lateral recumbent position optimal for CO, uterine perfusion)

Gravid Uterus elevates pressure veins draining legs, pelvic organs = slowed venous return, dependent edema, varicose veins, hemorrhoids

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20
Q

Preg Changes - Hem

A

Increased Blood Volume (>1500)
Na/Water retention due to changes in OSMOREGULATION, secretion of vasopressin by Ant. Pituitary, RAAS system

Increased RBC volume with IRON supplementation
Increased volume, oxygen carrying capacity needed for increased basal metabolic rate, need of uterine-placental unit
Plasma > RBC volume → Hemodulation, Decreased Hematocrit

Increased WBC

Increased Clotting Factors (fibrin, fibrinogen) = Hypercoag. State

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21
Q

Preg Changes - Pulm

A

Increased oxygen consumption, subcostal angle, ant.post. Diameter, tidal volume, min. Ventilation, min. Oxygen uptake

Gravid uterus places upward pressure on diaphragm (elv. 4cm)

Hyperventilation → Res.
Alkalosis (renal compensation → maternal pH 7.4-7.45)

Estrogen-induced edema → nasal congestion, epistaxis

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22
Q

Preg Changes - GI

A

Estrogen-induced hyperemia = gums bleed

Progesterone induced smooth muscle relaxation, delayed gastric emptying, decreased peristalsis = N/V “ morning sickness”

Decreased gallbladder emptying (increased risk of cholelithiasis)

Ptyalism (increased saliva production)

Constipation, heartburn, GERD

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23
Q

Preg Changes - GU

A

BLADDER:
1st Tri: pressure on bladder = frequency, nocturia, stress incontinence

2nd Tri: uterus occupies abd. Space = decreased urinary frequency

3rd Tri: Presenting part of descends into pelvis = urinary frequency, nocturia, stress incontinence

Increased GFR = Increased UOp
Increased Kidney size
Dilation of urinary collecting system = Physiologic Hydronephrosis

Urinalysis:
Glycosuria (increased glucose load), Protein excretion increases to do altered prox. Tubule function + increased GFR)

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24
Q

Preg Change - Skin

A

Hyperpigmentation (due to increased estrogen, increased melanocyte activity)
MELASMA (CHLOASMA) “mask of pregnancy”
LINEA NIGRA (line down abdomen)

Nippes, Areola, Vulva darken
Increased cutaneous blood flow = increased dissipation = pregnancy “glow”

Decreased connective tissue strength due to increased adrenal steroid levels = STRETCH MARKS (Striae Gravidarum)

Estrogen induced Vascular Permeability = Spider Nevi, Angiomas, Palmar Erythema

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25
Preg Changes - MSK
LORDOSIS: abd. Distension + shift in center of gravity Enlarged uterus = DIASTASIS RECTI (separation of abdominal rectus muscles) Increased joint mobility/Waddling gait Due to increased progesterone/relaxin Widened pubis symphysis Facilitates baby into pelvis High bone remodeling/turnover
26
Preg Changes - ENDO
Increase pituitary gland size = increased intrasellar pressure = increased risk of postpartum infarction (SHEEHAN SYNDROME) in the setting of PP Hem. Increased PTH (meets cal/ needs of fetal skeleton) Hypercortisolism: Increased need for estrogen, cortisol = increased glucocorticoid from adrenal glands = supports fetal somatic reproductive growth “Diabetogenic State” of pregnancy Increased need for glucose/insulin production = hypertrophy/hyperplasia of pancreatic beta cells DECREASED TSH = increased T3/T4 and gland enlarges Reproductive hormones: HCG from placenta Estrogen, progesterone from Corpus Luteum (in 1st/2nd tri) and from Placenta (3rd) Suppressed FSH, LH due to feedback from estrogen, progesterone, inhibin DECREASED Oxytocin throughout pregnancy = INCREASED at Labor Onset and POS. FEEDBACK REALLY INCREASED during 2nd (push) stage of labor
27
Nutritional Needs in Pregnant
Add 300 cals Expect ~ 25-35 pounds added 11lb (placenta, fetus, fluid), 2lb (uterus), 4lb (INCREASED BLOOD VOLUME), 3lb (breast), 5-10 (maternal reserves) **** 600 mcg FOLIC ACID RBC synthesis, growth, DECREASED RISK OF NEURAL TUBE DEFECTS **** 1,000-1,300 mg CALCIUM 60g of PROTEIN 27mg IRON = increased RBC
28
PRENATAL CARE SCHEDULE
→ PRENATAL CARE SCHEDULE: 4-28 weeks = MONTHLY 28-36 weeks = TWICE MONTHLY >36 weeks = WEEKLY
29
DIETARY SUPS IN PREG
Prenatal Vitamins FOLIC ACID CALCIUM IRON VITAMIN A (teratogenic in early preg) VITAMIN D
30
6 FINDINGS EVERY PRENATAL VISIT
→ Full physical exam at first visit → Every visit after record: Weight BP = ACOG HTN >140/90 UA = Glucose and Protein (24 hr protein is gold standard) Fundal height Fetal HR → 12 WEEKS = AUDIBLE Fetal Position → 36 WEEKS = palpable
31
→ Due Date Expectation = NAEGELE’s RULE
1st day of LMP + 7 days - 3 months + 1 year 1st day of LMP = 1st day of bleeding
32
FIRST PRENATAL VISIT
*** First Visit = 6 weeks after LMP *** HR with US detected around 5-6 weeks (1-2 wks after missed cycle) HCG PAP CHAL/GON CULTURE CBC RUBELLA SYPHILIS HEP B
33
FIRST TRIMESTER SCREEN:
FIRST TRIMESTER SCREEN: → 11-14 WEEKS: US for NUCHAL TRANSLUCENCY PAPP-A and hCG Low PAPP-A associated with Down Syndrome
34
Cell Free Fetal DNA
Cell Free Fetal DNA: → ~10 WEEKS: Fetal DNA in Maternal Blood Trisomies 13, 18, 21 + tests followed by CVS (Chorionic Villus Sampling) or Amniocentesis
35
Chorionic Villus Sampling:
Chorionic Villus Sampling: → 11-14 WEEKS: Placental Tissue to test for chromosomal and genetic abnormalities
36
Quad Screen
→ 16-18 WEEKS: AFP, HCG, ESTRIOL, Inhibin A Increased AFP = neural tube/ab. Wall. Increased hCG + Inhibin + Decreased AFP and Estriol = Down Syndrome Decreased AFP, hCG, and Estriol = Edwards Syndrome
37
Amniocentesis DONE PRENATALLY
→ 15-20 WEEKS: Collect Amn. Fluid to Dx Chromosomal AbnormalitieS
38
Glucose Challenge Test:
→ 24-28 WEEKS: 75 g 1 hr glucose challenge If abnormal = Repeat 3 hr
39
Group B Strep Test:
→ 35-37 WEEKS: Swab vagina and rectum
40
SYMPTOMS OF PREGNANCY + DX
SYMPTOMS OF PREGNANCY: → AMENORRHEA → NAUSEA → Increased urinary frequency → Breast engorgement ** CHADWICK’s Sign → blue discoloration of the vagina, vulva, cervix → Cervical Softening DX: Urine Preg. Test (UPT) Detects hCG or B subunit Sensitive to 1-2 weeks Ultrasound: Most accurate method to detect fetal size GESTATIONAL SAC = 5 WEEKS YOLK SAC = 6 weeks FETAL IMAGE = 6-7 weeks CARDIAC ACTIVITY = 8 weeks
41
Found on US by Weeks
GESTATIONAL SAC = 5 WEEKS YOLK SAC = 6 weeks FETAL IMAGE = 6-7 weeks CARDIAC ACTIVITY = 8 weeks
42
First Trimester Weeks/Visits
FIRST TRIMESTER (week 1-12) → Visit every 4 weeks (monthly) Evaluate for: Wt changes, BP, PEDAL EDEMA, FUNDAL HEIGHT Urine dip for GLYCOSURIA and PROTEINURIA Trace glucose is normal due to increased GFR Trace PROTEIN is NOT NORMAL (thinking preeclampsia) CELL FREE FETAL DNA = 10 weeks or greater Fetal DNA in Maternal Blood Can confirm with CVS or Amniocentesis Very sensitive/specific CHORIONIC VILLUS SAMPLING (CVS) = 10-13 weeks Small samples of placenta is taken to do genetic testing on (DNA analysis, cyotgenetics) INDICATIONS: >35, prior genetic d/o, carriers for genetic d/o, if first US shows congenital anomaly, abn. Aneuploidy screening RISKS: Maternal Alloimmunization or Vertical transmission of infx (HIV) Complications: Misscarrage, AM. Fluid Leakage
43
Second Trimester Weeks/Visits
SECOND TRIMESTER (WEEKS 13-26) *** Continue visits every 4 weeks → 15-18 weeks: TRIP MARKER SCREEN (hCG, AFP, Estriol) = Neural Tube Defects/Trisomies → 16-20 weeks: Amniocentesis IF >35 → 17 weeks: Movement Documented → 24 weeks: GLUCOSE SCREENING → 25-28 weeks: Repeat HCT
44
Third Trimester Weeks/Visits
THIRD TRIMESTER ( week 27-Birth) *** Every 4 weeks UNTIL 28 weeks → Then every 2 weeks until 36 → Then EVERY WEEK *** → UA, Blood Glucose → 28-30: GIVE RHOGAM (if Rh -) → 28-32: Pre-gestational diabetes = TWICE WEEKLY NON-STRESS TESTING UNTIL DELIVERY → 35-37: GROUP B STREP (strep agalactiae) → 36-40 weeks: IF needed cervical chlamydia and gonorrhea
45
Abortion (+ 5 types)
ABORTION: - Pathophysiology: → Loss of pregnancy before 20 weeks → RF: CHROMOSOMAL ABNORMALITIES (MC: Trisomy, Monosomy X) → FR from MOM: SMOKING, Previous Abortions, Infx, anatomy, Ashermans, BMI <18.5/>25 TYPES + PRESENTATION: ** VAGINAL BLEEDING + PAIN +/- TISSUE PASSING FROM VAGINA ** → Spontaneous: <20 weeks (Fetal HR present in Threatened, Inevitable, and Incomplete → NO FHR = Complete or Missed) Threatened: VIABLE PREGNANCY Bloody D/C <20 weeks + CLOSED CERVIX + Retained POC (without passage of tissue) Inevitable: OPEN CERVIX + Retained POC (without passage of tissues) Incomplete: OPEN CERVIX + some but not all POC passed (may be stuck in os/vagina) Complete: CLOSED CERVIX + Complete passage of fetal parts + placenta MISSED: NON-VIABLE PREG. Undetected fetus (No heartbeat) before 20 weeks but POC remain NO BLEEDING SEPTIC: infx of uterus before or after abortion → Medical Abortion (induced) - Diagnosis: → QUANT. B-HCG, CBC, **BLOOD TYPE** (Must know to give Rhogam or not) → Ultrasound Will show if Cervical Os is open or closed Will show if the POC have passed - Treatment: → EXPECTANT MANAGEMENT <13 weeks (allow for complete abortion to occur) → >13 weeks = MEDICAL ABORTION MISOPROSTOL (prostaglandin) or MIFEPRISTONE (antiprogestin) → 1st Trimester = D&C → 2nd Trimester = Dilation & Evacuation → SURGERY if ineffective/excessive blood loss
46
Ectopic Pregnancy
- Pathophysiology: → Embryo implants outside of the uterus MC = FALLOPIAN TUBE (Ampulla) → MCC: OCCLUSION OF TUBE due to ADHESIONS RF: HX of ectopic, previous salpingitis (caused by PID), previous abd./tubal surgery, IUD, assisted reproductive, smoking - Patient Presentation: → Bleeding + Abdominal Pain + Adnexal Mass in Pregnant Pt - Diagnosis: → POSITIVE HCG PREGNANCY TEST (>1,500) BUT NO FETUS IN UTERO Get serial HCGs (if they are rising but NOT DOUBLING - probs an EP) → US = RING OF FIRE SIGN = RING OF VASCULARITY - Treatment: → METHOTREXATE (if HCG < 5,000) Indications = Stable pt, <5,000, Mass<3.5, no fetal heart beat C/I: Breastfeeding, pulm.ds, immunodef. FOLIC ACID ANTAGONIST → Inhibits DNA replication → Surgery → Laparoscopy Salpingostomy = if ruptured or CI for Methotrexate *** MUST FOLLOW UP *** - PEARLS: → RUPTURED: (medical emergency) SEVERE ADB. or SHOULDER PAIN, peritonitis (guarding), tachycardia, syncope, ortho. HTN
47
Gestational Diabetes
- Pathophysiology: → Pregnant pt with abnormal glucose tolerance → MC diagnosed in 2nd or 3rd trimester if it was not clearly present prior to pregnancy → RF: Obesity, Hx of impaired glucose tolerance, FHx DM, Maternal age > 30 Given birth to baby >9lb, PCOS, Non-white → MC Complication = MACROSOMIA - Patient Presentation: - Asymptomatic (may have typical DM symptoms) - Diagnosis: → Random Glucose in ALL pregnant women the 1st Prenatal visit!!!! REPEAT at 24-28 weeks → 1 hour Glucose Tolerance Testing @ 24-28 weeks Non-fasting 50-g glucose challenge test followed by serum glucose level 1 hour later > 130 → Do 3 hr glucose test 100g 3 Hour Glucose Test: if 2 or more of these levels are positive = Positive Dx Fasting: 95 1 hr: >180 2 Hr: >155 3 Hr: >140 - Treatment: → Daily glucose checks (fasting overnight and after each meal) → Insulin if fasting > 105 mg (TX of Choice) → GLYBURIDE (Only oral hypoglycemic that DOESN’T CROSS PLACENTA – BUT – Higher risk of Eclampsia) → EARLY DELIVERY = C-SECTION AT 38 WEEKS (if child is macrosomic) → Weekly fetal HR
48
GESTATIONAL TROPHOBLASTIC DISEASE (Non-malignant and Malignant)
→ Proliferation of Placental Cells → RF: < 20/>35, Previous Molar Preg. → Benign (Molar Preg/Hydatidiform Mole) → Malignant (Invasive Moles & Choriocarcinoma) ****** EXTREMELY HIGH HCG >100,000 *** → MOLAR PREGNANCY: Premalignancy (HYDATIDIFORM MOLE) COMPLETE MOLE: HUGE HCG >100, 000 + missed periods, + preg. Test, vaginal bleeding, syms of hyperthyroidism, UTERUS is LARGER THAN EXPECTED “Grape-like” mass or SNOW-STORM on US INCOMPLETE MOLE: More than usual HCG (not as much as Complete), Uterus is NOT larger than normal, most result in spontaneous abortion →Malignant → INVASIVE MOLE: Derives from benign mole ALWAYS AFTER MOLAR PREG> → CHORIOCARCINOMA: PLACENTAL CANCER occuring in the absence of a molar pregnancy Can develop after a normal or molar pregnancy Diagnosis: → HCG > 100,000 → Transvaginal US: “Snowstorm” / “Swiss Cheese” → ECHOGENIC pattern from the abnormal placenta villi and clots Complete Mole: THECA LUTEIN CYSTS Incomplete Mole: Fetal Parts may be visible - often Oligohydramnios → Invasive and Choriocarcinoma: Dx made bc HCG Levels PLATEAU Invasive US = ANECHOIC & high vascular flow Choriocarcinoma = Single Mass distending the uterus and is HETEROGENEOUS bc it has areas of necrosis and hemorrhage ORDER Chest X-RAY & CT head, abd., pelvis for Metastases!!!! Stage 1: ONLY uterus Stage 2: Tubes, Ovaries, Vagina Stage 3: LUNGS Stage 4: Any organs other than lungs or genitals Treatment: → Complete/Incomplete: UTERINE EVACUATION via SUCTION CURETTAGE Follow up & measure HCG weekly until gone for 3 weeks then once a month for 6 months (use contraceptives) HCG rises or plateaus, there may be an invasive mole or choriocarcinoma → Choriocarcinoma: RESECT, METHOTREXATE, CHEMO 0-6 = low risk >6 = high risk + Chemo (EMA-CO) ** Remission = 3 consecutive undetected HCGs **
49
Incompetent Cervix
- Pathophysiology: → SPONTANEOUS, premature DILATION or SHORTENING of the Cervix during the 2nd or early 3rd trimester (up to 28 weeks) → RF: H/o of cervical insufficiency, hx of injury, surgery, colonization, etc. - Patient Presentation: *** RECURRENT 2nd TRI. MISCARRIAGES *** → PAINLESS dilation (>2cm) and effacement, minimal contractions until 4cm → bleeding or vaginal d/c - Diagnosis: → Transvaginal US = “Funneling of the cervix” → 18-22 weeks = US focuses on abnorm. → NORMAL CERVIX LENGTH = 30mm → CERVICAL WEAKNESS = <25mm before 24 wks (<2.5cm) - Treatment: → CERVICAL CERCLAGE @ 12-14 weeks Removed @ 36-38 weeks → Culture for GBS before inserting + confirm viable pregnancy
50
Placenta Abruption
- Pathophysiology: → Placenta detaches from the Uterus too early >20 weeks causing hemorrhage → MCC OF 3rd TRIMESTER BLEEDING → RF: Trauma, Smoking, HTN, Preeclampsia, Cocaine - Patient Presentation: → PAINFUL 3rd Trimester Bleeding + severe abdominal pain + frequent small contractions + FIRM, TENDER UTERUS - Diagnosis: → CLINICAL **BLOOD STAINED AMNIOTIC FLUID** → US may show Retroplacental Blood Collection - Treatment: → DELIVERY = Definitive Blood type, Crossmatch, Coag. studies + LARGE BORE IV Corticosteroids as needed = Enhance Fetal Lung Maturity
51
Placenta Previa (and types)
- Pathophysiology: → Placenta lies LOW in the uterus and covers the cervix → RF: Prior C-Section, Multiple Gestations, Multiple Induced Abortions, Advanced Maternal Age → NORMAL LOCATION: FUNDUS, which is the top, rounded part of the uterus “Low-Lying” Placenta: Implanted in the lower uterus, NOT extending to the internal os “Marginal” Previa: EDGE of placenta reaches the margin of the os “Partial” Previa: Placenta covers PART of the internal os “Complete” Previa: Placenta completely covers the internal os VASA PREVIA: Fetal vessel lies over the cervix ** FETAL COMPLICATIONS: Preterm Delivery, Preterm PROM, IUGR, Vasa Previa, etc. - Patient Presentation: → PAINLESS bleeding after 28 weeks Thinning of the lower uterus segment in the 3rd trimester → No pain or cramping - Diagnosis: → Do NOT do VAGINAL Exam (can cause further separation) → TRANSVAGINAL ULTRASOUND - Treatment: → STRICT PELVIC REST + NO INTERCOURSE Type and Screen incase the need for transfusion C-Section = Preferred If Rh- = Give Rhogam
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Hypertension in Pregnacy (Not Pre/Eclampsia)
- Gestational HTN: → BP >150/90 after 20 weeks into pregnancy that resolves 12 weeks postpartum ****NO PROTEINURIA**** -Chronic HTN: → BP>140/90 PRIOR TO 20 wks Gestation that persists >6 weeks postpartum ***NO PROTEINURIA*** → Monitor every 2-4 weeks and weekly at 34-36 weeks - Treatment: → Gestational = May withhold meds (Hydralazine or Labetalol are safe if needed) → Chronic = > 150/100 = TREAT (severe) Labetalol or Nifedipine Oral Hydralazine added if needed Methylodopa (safe alternative, but hard to use) AVOID ACE/DIURETICS
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Rh Incompatibility
- Pathophysiology: → Mothers blood type is Rh (-) → Risk baby being born with Rh (+) blood which can cause ANTIBODIES AGAINST THE BABY’S BLOOD **** 1st pregnancy = always UNAFFECTED - Diagnosis: → ALL pregnant women: - ABO Blood Group - RH-D Type - Indirect Erythrocyte Ab Screen - Indirect Coombs Test → Fetal Monitoring in 2nd Trimester - Treatment: → Give RHOGAM at 28 weeks, within 72 hours of delivery AND during any uterine bleeding throughout pregnancy Or if assumption of abortion Given if Rh- mom and Father is Rh+ or unknown RISK: Hydrops Fetalis → large amount of fluid builds up in babies tissues and organs causing extensive swelling (not a good survival rate)
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Breech Positioning
- Pathophysiology: → Fetus is not head down = “Bottom-first” → DECREASED likelihood with increased gestational age - Patient Presentation: → 3 Type: FRANK: MC → Both Hips are Flexed and both knees are extended COMPLETE: Both hips extended + knees bent INCOMPLETE: One hip flexed, one extended + knee bent FOOTLING: both legs and knees extended - Diagnosis: → PHYSICAL EXAM → US Confirms: Observe and Repeat US at 37 weeks - Treatment: → ECV (external cephalic version) Technique: @ 37 weeks → Head down, pillow under knees, IV TOCOLYTIC, trying to lift breech from pelvis (other practitioner on head) → Trial of Vaginal Delivery → if persistent → C-Section
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Dystocia
- Pathophysiology: Obstructed Labor → Obstruction of Labor **SHOULDER DYSTOCIA: Failure of the shoulders to deliver spontaneously after the delivery of the head → RF: Macrosoma from Gestational DM, Ab. Positioning, small pelvis → Complications: Baby = Hypoxic Mom = infx, uterine rupture, PP Bleeding 3 Categories: POWER: uterine contraction PASSENGER: macrosomia, shoulder dystocia PASSAGE: uterus or soft tissue abnormalities - Patient Presentation/DX: ** TURTLE SIGN: HEAD DELIVERS AND SUDDENLY RETRACTS AGAINST PELVIS → US = Predicts malpresentation - Treatment: → Change Positioning of Mom → May require C-Section or Vacuum Extraction (possible surgical symphysiotomy) **SHOULDER DYSTOCIA: 1st line = NON-MANIPULATIVE MANEUVERS McRoberts Maneuver = Flexion of maternal hips 2nd line = Manipulative Maneuvers: Wood’s Corkscrew: Rotation of fetal shoulder 180 degrees Delivery of posterior arm 3rd = Push fetal head back in and immediate C-Section with Zavanelli Maneuver
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Fetal Distress
NORMAL Fetal HR: 120-160 → >160 for 10 mins = BRADY → <120 fro 10 mins = TACHY NONSTRESS TESTING: → Records movement, heartbeat, and contractions → GOOD = REACTIVE NST >2 accelerations in 20 mins Accels = increase in FHR of at least 15 bpm from baseline, which lasts > 15 seconds → BAD = NONREACTIVE NST No FHR acceleration OR < 15 bpm increasing lasting longer than 15 secs If this occurs get a contraction stress test *** DECELS = BAD *** CONTRACTION STRESS TEST: → Measures fetal response to stress at times of contraction GOOD = NEGATIVE CST No late decelerations in the presence of 2 contraction in 10 minutes BAD = POSITIVE CST Repetitive late decelerations in the presence of 2 contractions in 10 minutes APGAR Score: → Appearance, Pulse, Grimace, Activity, Respirations >7 = Normal, <3 = Critically Low
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Premature Rupture of Membranes
- Pathophysiology: → Rupture of membranes greater than or equal to 37 weeks aka “water broke” → RISK = Infection or Cord Prolapse - Patient Presentation: → Gush of fluid (clear or pale yellow) from vagina after 37 weeks - Diagnosis: → Nitrazine Test: BLUE (elevated pH = > 7.1 = positive amniotic fluid) → Microscopic Exam: FERNING Crystallization of amniotic fluid (+ estrogen) - Treatment: → >34 weeks: Induce Labor → 32-34 weeks: Collect fluid + check for lung maturity → Induce → <32 weeks: STOP contractions + 2 doses of steroid injx → DELIVER GIVE ABX
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Preterm Labor
- Pathophysiology: → Born < 37 weeks (Normal = 40) → Earlier the baby is born, the greater risk of complications (especially to the respiratory system) → Earliest possible with 50% survival rate is 24 weeks → RF: Smoking, cocaine, uterine malformations, cervical incompetence, infection, low pregnancy weight - Patient Presentation: → Contractions occurring more often than every 10 minutes OR leaking of fluid from the vagina → “Coordinated Contractions” every 3 mins (example) - Diagnosis: → FETAL FIBRONECTIN: (22-34 weeks) Differentiates women who are high risk for preterm than others Used in women with symptoms of preterm labor by measuring the level in secretions form the vaginal/cervix → Placental Alpha Microglobulin-1 (PAMG-1) - - Biomarker that identifies PROM → Obstetric US: Short cervix preterm = indesirable <25mm at or before 24 weeks = Cervical Incompetence = risk of preterm - Treatment: → TOCOLYSIS: Delay Delivery NSAIDS, CCB, Beta Mimetics, or Atosiban Relax the uterus GOAL: Delay onset of labor until STEROIDS can be administered <34 weeks CCBs: NIFEDIPINE and Oxytocin Antagonist can delay delivery by 2-7 days B2 Agonist delay delivery by 48 hrs Magnesium Sulfate: DOES NOT WORK (but decreases risk of cerebral palsy) → At risk ⇒ Progesterone (if taken during pregnancy) may prevent preterm birth → Give steroids < 34 weeks (24-37)
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Prolapsed Umbilical Cord
- Pathophysiology: * Emergency * → Umbilical cord comes out before the baby → Risk: Fetal Hypoxia, Brain Damage, Death → RF: Malpresentation and ROM - Patient Presentation/Diagnosis: → SUDDEN & SEVERE DECREASE in FHR Does not immediately resolve → On Fetal HR Tracing (NST): VARIABLE DECELERATIONS - Treatment: EMERGENT C-SECTION → Place patient in Knee-Chest Position and MANUALLY ELEVATE the CORD → get to delivery room for emergent delivery
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ENDOMETRITIS
- Pathophysiology: → Inflammation of the endometrium from bacteria → MC infx after childbirth → Causes: birth, procedures, IUD, Chlamydia, Gonorrhea → Risks: C-section, PROM, Vaginal delivery, D&C, Pelvic exams → Acute (Symptoms), Chronic (Asymptomatic) → COMPLICATIONS: Myometritis (bacteria spreads into myometrium) or Parametritis (spreads into parametrium) Salpingitis or Oophoritis Chronic can lead to Asherman Syndrome (Intrauterine Adhesions) - Patient Presentation: → Fever, Tachy → Possible vaginal bleeding (FOUL-smell) 2-3 Days post-c-section, post-abortion - Diagnosis: → Clinical → Endometrial Biopsy = Helps Diagnosis → Histology = Neutrophils in the endometrium - Treatment: → AFTER CHILDBIRTH: CLINDAMYCIN + GENTAMICIN → REMAINING PLACENTAL/FETAL TISSUE/POST-ABORTION: D&C → CHLAMYDIA/GONORRHEA: DOXY + CEFTRIAXONE - PEARLS:
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Postpartum Hemorrhage
- Pathophysiology: → Significant loss of blood after delivery Greater than or equal to 1,000mL in the first 24 hours after birth Decreased Hmt 10%, changes in HR, BP, O2 * #1 reason for maternal death worldwide * → 4 MC Causes: “4 Ts” Tone: UTERINE ATONY (MC) Boggy, Enlarged Uterus Doesn’t contract after to stop clotting Trauma: Forceps, vacuum, precipitous labor Tissue: Incomplete separation of placenta from uterine wall or expulsion of placenta isn't complete Thrombin: Coagulation D/O Prevents blood clots from forming naturally (von Willie, eclampsia, placenta abruption, DIC) *DIC = severe preeclampsia, amniotic fluid embolism, placental abruption* - Treatment: → Uterine Atony = FUNDAL MASSAGE + (oxytocin IV, misoprostol = helps contract) → Genital Trauma = >2cm = Surgically Repaired → Retained Placental Tissue = Placenta Accreta Placenta grows too deeply into uterine wall Hysterectomy
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Normal PP period
→ Last ~ 6 weeks Immediate: first 24 hrs (acute postanesthetic/post-delivery complications) Early: extends until first week Remote: period of time required for the genital organs and return of menses to occur (~6 weeks(
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Uterus & Placental PP
→ Uterine Involution: First week → decreased to size of 12 week gestation & is palpable at pubis symphysis → Placental Implantation Site Changes: Immediate contraction of the placental site to the size less than half the diameter → leads to hemostasis NORMAL POSTPARTUM DISCHARGE aka LOCHIA RUBRA: blood, shreds of tissue, and decidua → over 3 days it changes to brown d/c 5th/6th week PP = Lochial secretions stop
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Cervix, Vagina, Walls of Pelvic Organs - PP
Cervix gradually closes → by the end of the 1st week it is back down to ~1cm The vagina returns to its antepartum condition by ~3rd week OVULATION occurs as early as 27 days after delivery, but average: 70-75 days in non-lactating 6 months in lactating Changes in the pelvis = widened symphysis and SI Joints Pelvic floor gradually regain tone Tearing/overstretching of the muscles can lead to prolapses and hernias Overdistension of abd. Walls can result in striae, diastasis of the rectus muscles 6-7 of no vigorous exercise
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Urinary System PP
Immediate PP = bladder mucosa is edematous and there is an INCREASED BLADDER CAPACITY Overdistention and incomplete emptying of bladder + residual urine Urinary stasis until ~ 12 weeks PP Increase UTI risk if distended Mild Proteinuria for 1-2 days Increased GFR until about 8 weeks Creatinine clearance returns normal ~8 weeks
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Management of PP (hospital, activity, diet, sex, bathing)
2-4 days hospitalization PP RETURN home safely 2 days after normal vaginal delivery Optimal = 4th day home nurse visit ACTIVITY = out of bed as soon as tolerated if uncomplicated delivery Exercise does not compromise lactation of neonate weight gain Decreases anxiety and PPD DIET = regular diet is permissible asap Protein rich food, fruits, veggies, high fluid intake 500kcals per day more than non pregnant/non lactating women SEX: when bleeding stop and perineum is comfortable Median time is 6 weeks and normal sex response 12 weeks Bathing: ASA Ambulatory
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Care of Perineum PP
Normal cleaning/showers Immediately after delivery: cold compresses to decrease edema Gently cleaned with plain soap once or twice per day and after voiding to keep clean and avoid infection