wound care (M 1-9: measurements, tissue types and staging, exam, diabetes, arterial, venous) Flashcards

(103 cards)

1
Q

integument – skin is

A
  • the body’s largest organ
  • 15-2-% of body weight
  • surface area between 1.5-2 m^2 (~22ft^2) in the average adult
  • thickness of 0.5-4 mm (average 1-2 mm)
  • thinnest on eyelids, thickest on heels
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2
Q

functions of the skin

A
  • protection/immunity: protects against pathogens, decreases water loss
  • temperature regulation: provides insulation, related to dilation and constriction of blood vessels within the layers of the skin, allows for sweating
  • sensation: contains various nerve endings, including for pain, light touch, etc
  • assists in vitamin D synthesis, and indicator of vitamin B levels
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3
Q

anatomy of the skin - layers of the epidermis

A
  • stratum corneum
  • stratum lucidum
  • stratum granulosum
  • stratum spinosum
  • stratum basale
  • basement membrane
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4
Q

stratum corneum

A
  • most superficial - acts as the primary barrier
  • composed of soft keratin-containing, dead squamous cells, constantly sloughing or shedding
  • 15-20 layers od ead cells
  • can also indicate hydration - ashy skin means dehydration
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5
Q

stratum lucidum

A
  • thin, clear layer od dead skin cells
  • typically only seen in regions like the palms of the hands and soles of the feet
  • areas of increased stress to the tissues
  • function to reduce sheer/friction to epidermis
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6
Q

stratum granulosum

A
  • layer that contains transition zone for the development of keratin
  • becoming more active cells again
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7
Q

stratum spinosum

A
  • layer contains “spiky/spiny” projections
  • gives integrity, holds things together
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8
Q

stratum basale

A
  • deepest and most continuous layers of epidermis
  • typically 1-3 cell layers thick
  • regenerates the epidermis: growing new cells, go up, slough off eventually
  • contianing a variety of other cells, including:
  • merkel cells - touch receptors
  • langerhands cells - immune cells
  • melanocytes - pigment production
  • keratinocytes - produces keratin (fibrous proteins), antibodies and enzymes
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9
Q

basement membrane

A
  • the layer that separates the epidermis and dermis
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10
Q

dermis

A
  • the thickest layer
  • primary functions
  • thermoregulation
  • storage of water/maintaining hydration
  • provides nutrients and waste removal for itself and the epidermis
  • also contains: blood vessels, lymphatic vessels, glands - sebacious, sweat, nerve endings, hair follicles, collagen
  • papillary region
  • bumpy surface that interdigitates with dermis, strengthening the connection
  • influences the contours of the skin’s surface - finger prints
  • reticular region
  • contains collagen, elastic, and reticular fibers - provides strength, extensibility, and elasticity
  • contains the roots of the hair, sebaceous glands, sweat glands, receptors, nails, and blood vessels
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11
Q

hypodermis

A
  • subcutaneous tissue
  • attaches skin to underlying bone and muscle
  • contains loose connective tissue, adipose tissue, and elastin
  • contains 50% of body fat
  • provides insulation and shock absorption
  • contains Pacinian cells and free nerve endings - cold and pressure
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12
Q

risk factors for wound healing

A
  • comorbidities: CV, diabetes, SCI
  • nutrition: malnutrition
  • obesity
  • smoking, alcohol/drug use
  • sedentary or limited mobility
  • impaired sensation
  • risk-prone behavior - high-risk activities, exposure
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13
Q

extrinsic factors of wound healing

A
  • shoes - condition and fit
  • orthotics, prosthetics
  • seating - cushions and positioning
  • hairstyles
  • vital signs and sensory testing
  • other exam items: MMT, goniometry
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14
Q

how many people per year in teh US develop pressure injuries, associated with pain, risk for infection, increased health care utilization

A

more then 2.5 million people per year

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15
Q

diabetic foot ulcers have a mortality rate of []% and as high as []% after BKA

A
  • 43-55%
  • 74%
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16
Q

venous leg ulcers have a 6-month healing rate of []% and a [] recurrence within 5 years

A
  • 45-70%
  • 25-70%
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17
Q

patients > 45 YO have a prevalence of PAD (peripheral arterial disease) of []%

A
  • 14.9%
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18
Q

primary intention

wound closure managment choices

A
  • clean, straight line, edges well approximated with sutures
  • rapid healing, usually best cosmetic outcome
  • usually after surgeries
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19
Q

secondary intentions

wound closure managment choices

A
  • larger wounds with tissue loss, edges not approximated, heals from inside out
  • granulation tissue fills in wound, longer healing time, larger scars
  • edges do not come together
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20
Q

tertiary intention (delayed primary)

wound closure managment choices

A
  • delay is typically 3-5 days before injury is sutured
  • used to manage infected or unhealth wounds, larger scar
  • secondary with surgery to close: may be surgeon preference, may be due to other factors
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21
Q

wound healing: inflammatory phase

A
  • start immediately with hemostasis and includes the innate immune system (inflammation)
  • exposed collagen activates clotting cascade
  • cytokines/chemokines and growth factors are released by resident cells and cells that migrate to area of wound
  • neutrophils, monocytes, and macrophages are essential:
  • pathogen control: production reactive oxygen species (ROS)
  • pathogen and debris removal: phagocytosis
  • angiogenesis: PDGE, TGF alpha and beta, TNF alpha
  • fibroplasia: interleukins, EGF, TNF alpha
  • what you notice: local erythema, edema, tenderness
  • main function is to remove debris, start healing cascade, and prepare wound for regeneration
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22
Q

wound healing: proliferative phase

A
  • day 4 through several weeks
  • fibroblasts are most important cell type: produces collagen to fill wound and provide support
  • angiogenesis (neovascularization): capillaries “bud” from nearby vessels and grow into wound
  • epitheliazation: epithelial cells from wound margins migrate across wound surface
  • wound contraction: pulling of edges toward center making wounds smaller
  • myofibroblast: contractile properties and collagen synthesis
  • growth of blood vessels, deposition of collagen, formation of granulation tissue, epithelialization, wound contraction
  • granulation tissue: new connective tissues into a space, red/pink, “beefy” looking
  • epithelializing tissue: thin shiny over red, good
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23
Q

epithelialization

A
  • epithelial cells migrate across the new tissue to form a barrier between the wound and the environment
  • basal epithelial cells at the wound margin: multiply (mitosis) in horizontal direction, flatten (mobilize) and migrate into open wound
  • basal cells behind margin undergo vertical growth (differentiation)
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24
Q

wound healing: remodeling phase

A
  • up to 2 years
  • collagen Type III replaced by Type I
  • disorganized collagen fibers are rearranged, cross-linked, and aligned along tension lines (Langer’s lines - natural orientation of collagen fibers in dermis)
  • wound may increase in strength for up to 2 yearss after injury (return to about 80% of natural strength, at day 14 have about 30-50% tensile strength)
  • apoptosis – works to prevent keloids
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25
wound healing: system factors
* nutrition/hydration * diabetes * peripheral vascular disease (PVD) * GERD * collagen disease * end stage renal disease (ESRD) * immunosuppression * aging * medications * social/health habits * functional status and activity level * infection * paresthesia * perfusion * incontinence
26
wound healing: local factors
* psychological function - stress, memory, anxiety * hypergranulation * tobacco use * high bacterial burden * biofilms * edema * pressure/friction/shear * maceration/motion * hyperkeratosis * cellulitis * nonviable tissue * lack of growth factors * cytokines * matrixmetalloproteases (MMPs)
27
blanchable vs non-blanchable
* blanchable: reddened area that turns pale under applied light pressure * non-blanchable: an area of redness that does not blanch under applied light pressure -- more concerning for pressure injuries
28
abnormal: blue skin colors
cyanosis
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abnormal: purple skin color
* deep tissue injury * may be darker or gray in darker skin
30
abnormal: red color
* infection or inflammation * could be cellulitis or dermatitis - raised * erythemia - flat, shiny
31
erythema
* abnormal red color * may indicate underlying infection * indicative of Stage 1 pressure injuries if over bony prominence * may be a 1st degree burn
32
abnormal: red skin with covid
* pediatric multisystem inflammatory syndrome (PMIS) -- purplish lesions on toes and feet, rash * Covid toes * Coronavirus rash
33
abnormal: red skin colors indicative of other issue
* bulls-eye rash: Lyme disease * rashes - drugs
34
other abnormal skin colors
* white: reynaud's, dully ashy/gray in darker skin * black: necrosis, gangrene * yellow: jaundice, visible in eyes (liver disease, hemolytic disease * hemosiderin staining: mostly in LEs, red/rusty brown or brownish purple, usually in gaiter area (socks), common in chronic venous insufficiency (starts distal and moves proximally
35
petechiae, purpura, and ecchymoses differences
* petechia: small (1-2 mm; < 3 mm), red or purple spot on the skin * purpura: > 3 mm * ecchymosis: > 1 cm, commonly called a bruise * all do not blanch with pressure
36
edema
* excess fluid in interstitial tissue * can be multi-factorial in cause * impedes healing regardless of etiology * extent and type of edema helps identify wound etiology
37
localized edema
* sign of infection * result of inflammatory response in the immediate wound area
38
unilateral edema
* can be indicative of venous insufficiency, DVT, lymphatic blockage
39
bilateral edema
* probably more central body cause -- heart failure
40
pitting edema
41
edema - induration
* orange-peel texture * more chronic edema
42
signs of acute inflammation
* rubor - redness * fumor - swelling * calsor - heat * dolor - pain * loss of function * odor, pain, palpation, systemic changes, wound cultures
43
chronic wounds
wounds that fail to progress through a normal, orderly, and timely sequence of repair or wounds that pass through the repair process without restoring anatomic and functional results
44
diagnosing wounds
* by tissue involvement -- to determine local care: superficial/erosion, partial thickness, full thickness * by etiology -- to determine systemic care: arterial, venous insufficiency, neuropathic, pressure, atypical
45
questions to ask in exam about wounds
* when did the wound begin * how did the wound begin -- trauma, falls, bites * other s/s -- fever, itching, pain * treatments already tried * allergies relevant -- latex, sulfa, adhesives * tobacco, alcohol, drugs
46
wound examination -- objective measures
* dimension/extensions * tissue type * staging * wound bed color * drainage * wound edges
47
dimensions | size
* **methods** * perpendicular: widest points x widest points * clock: 12 at head * volumetric: how much saline can you put in * tracing * photography * typically documented as: length (cm) x width (cm) x depth (cm)
48
subcutaneous extensions
* tunneling/sinus tract: narrow passage of tissue destruction within the wound * undermining: destruction of the conenctive tissue between teh dermis and subcutaneous tissue -- extends under the intact skin along the periphery of a wound * fistula: tunneling that connects with a body cavity
49
abrasion
* skin is rubbed/scraped * usually not much bleeding * heals fairly quickly * ex: road rash
50
avulsion
* partial or complete tearing away of skin/tissue * bleeds heavily and rapidly * ex: violent accidents, crush accidents, explosions, gunshots
51
puncture
* small hole caused by pointy object * may not bleed much, can damage organs * ex: nail, bullet, needle
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laceration
* deep cut or tearing of skin * bleeding can be rapid and extensive * ex: knives, tools, machinery
53
granulation tissue
* red, "beefy" looking * result of angiogenesis -- formation of new blood vessels * composed of new capillaries and ECM * varies in color from anemic (pale pink) to bright red * necessary for closure by secondary intention or for split thickness skin grafts * carefully protected in good wound management
54
slough
* softer, lighter necrotic debris * normal by-product of autolysis * usually seen beneath eschar (black) * more common in the inflammatory phase of healing * differs from adhered connective tissue in that it is soft and mushy, sometimes hard to grasp with forceps * yellowish
55
eschar tissue
* composed of dead cells and fibrin * may be dry and hard or soft and rubbery, leathery * may be dry gangrene or wet gangrene -- wet is infections * can be burn, fungal infectoin, bug bites * can let it be until infected * gangrene generally in hands and feet
56
muscle tissue
* striated * reddish when healthy -- brownish-gray when devitalized * sensate when healthy -- painful when exposed * may see movement if you ask pt to move
57
tendons
* shiny and stringy when healthy -- becomes dull and dry when devitalized/necrotic * covered with a fibrous sheath of connective tissue containing synovial fluid or fatty fluid (paratenon) * may see movement if you ask patient to move
58
bone
* tan in color -- dark brown when necrotic, can soften (osteomyolitis) * hard to palpation with metal instrument * covered with periosteum when healthy -- has to be debrided if necrotic
59
adipose
* shiny, yellow-white globules when healthy -- shriveled and dry when devitalized * poorly vascularized -- challenging to heal * frequent sources of abscess formation
60
skin loss/wounding
* erosion: loss of epidermis only (abrasion) * partial thickness: loss of epidermis and part of dermis * full thickness: loss of all epidermis, dermis, and into subcutaneous tissue | NOT pressure injuries -- classification of skin loss
60
skin loss/wounding
* erosion: loss of epidermis only (abrasion) * partial thickness: loss of epidermis and part of dermis * full thickness: loss of all epidermis, dermis, and into subcutaneous tissue | NOT pressure injuries -- classification of skin loss
61
pressure injury stages
* stage 1: warm to touch, no breaks or tears in skin * stage 2: no slough, can look like blister, partial thickness * stage 3: full thickness but no muscle, tendon, or bone; can see tunneling and fat * stage 4: full thickness with muscle, bone, tendon; do see tunneling and undermining, can see eschar and slough * unstageable: cannot see full depth of wound due to eschar or slough in the way
62
deep tissue injury | DTI
* looks like bad bruise * mushy, boggy, non-blanchable * may be intact or not * from high presure, prolonged pressure, sheer forces * often open as stage 3 or 4 pressure injuries * common over greater trochanter, sacrum, heels -- but can be over any bony prominence * ex: elderly patient who fell and was down for a long time until found
63
necrotic wounds are dry and [color]
black -- eschar
64
wounds with slough are [color]
yellow
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granulating wounds are
red
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epithelising wounds are shiny and [color]
pink
67
infection in tissue is [color]
green
68
drainage/exudate
1. sanguineous: thin, bright red 2. serosanguinous: thin, watery, pale red to pink 3. serous: thin, watery, clear 4. purulent: thick or thin, opaque tan to yellow 5. foul purulent: thick opaque yellow to green with offensive odor
69
how much drainage
* none: wound tissues dry * scant: wound tissues moist, no measurable drainage * small: wound tissues very moist, drainage <25% dressing * moderate: wound tissues wet, drainage involves 25-75% dressing * large: wound tissues fill with fluid, involves >75% dressing
70
wound edges can tell you
* type of wound or healing process occurring within a wound bed
71
even wound edges are typical of
arterial wounds
72
irregular wound edges are typical of
* venous wounds * may occur as wound epithelializes
73
rolling wound edges are
* sign of halted healing process * cells are termed senescent, meaning they are unable to reproduce * rolled edge is termed epibole
74
hyperkeratosis wound edges are
* overdevelopment of the horny layer of the skin * appears as thickened skin around the edge of a wound or as a callus
75
maceration wound edges are result of
* too much moisture on skin for too long * can slow healing process * creates high risk for infection and/or wound becoming larger
76
dehisced wound
* wound edges come apart * may be superficial layers only * or can open full depth
77
pain
* deep pain: cramping, indicative of ischemia or hypoxia, more comfortable in dependent position * throbbing, localized pain: indicative of infection, deep pain that increases with pressure may be indicative of osteomyelitis * superficial tenderness: exposed nerve endings, may be accompanied by sharp shooting pains * pain with stimulation of red tissue: living muscle
78
vascular testing - arterial
* pulses: use grading scale, compare side to side/above and below * doppler: for pulses that are not palpable * ABI: ankle brachial index
79
indications for a wound culture
* local signs of infection: pus, change in color or character of exudates, redness, induration, changes in wound odor * systemic signs of infection: fever, leukocytosis * suddenly elevated glucose * pain in neuropathic extremity * lack of healing after 2 seeks in a clean wound despite optimal care
80
DIMES
* debridement * infection/inflammation * moisture balance * edges * support services
81
diabetes mellitus
* 25.8 million children and adults in US (8.3% of population) * up to 14.5% in ethnic groups * 15% of people with DM will have wounds: 14-24% of those with diabetic ulcers will ultimately have an amputation * mortality following amputationincreases with level of amputation and range from 50-68% at 5 years * hyperglycemia can lead to stiffer blood vessels: leads to reduced tissue oxygenation, more difficult healing, more likely to get a wound
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clinical manifestations of DM
* **neuropathy**: diabetic peipheral neuropathy * type I: after 20 years of disease duration, at least 20% of people have DPN * type II: after 10 years of disease duration, 50% of people have DPN (more likely) * **sensory**: decreased sensation, vibration, proprioception, loss of reflexes (distal to proximal) -- impacts longer nerve fibers * experience neuropathic pain: gabapentin * **motor**: progressive weakness and atrophy * **autonomic**: decreases sweat and oil production: leads to dry, inelastic skin * heart and vasculature: orthostasis and silent MI * GI tract: gastroparesis, diarrhea * neuropathy/DPN: most common complication of DM type I and II * testing should involve neuromuscular assessment
83
monofilament sensory exam
* for protective sensation
84
vibration sensory exam
* more sensitive than monofilament testing * 128 Hz tuning fork * clanging tuning fork test * 4s - 100% sensitive for sensory loss: monofilament testing 76% sensitive
85
DM clinical manifestations -- osteopathy
* Charcot's disease: neuropathic arthropathy -- progressive degeneration of weight-bearing joints, increase risk of skin breakdown * due to abnormal pressure distribution * combined with DPN -- increased wound risk
86
complications of vascular and neuropathic changes
* ulceration (often painless): can lead to amputation * neuropathic edema * charcot arthropathy * callus formation: wound can develop under callus
87
skin and nail changes with diabetes
* nearly 1/3 of patients with DM have some type of dermatologic manifestation * up to 50% of patients with type 2 DM are at an increased risk of developing skin infections * related to: poor glucose control, abnormal carbohydrate metabolism, artherosclerosis (4x more likely in pts with DM), microangiopathic changes, neuro degneration, pharmacological therapy for DM (use of insulin) * diabetic thick skin: loss of elasticity, commonly with shiny appearance, can lead to limited joint mobility and contractures, more common in hands and fingers, usually dorsum, overall thickening * diabetic yellow skin: yellow nails and skin discoloration, usually on palms of hands or soles of feet
87
skin and nail changes with diabetes
* nearly 1/3 of patients with DM have some type of dermatologic manifestation * up to 50% of patients with type 2 DM are at an increased risk of developing skin infections * related to: poor glucose control, abnormal carbohydrate metabolism, artherosclerosis (4x more likely in pts with DM), microangiopathic changes, neuro degneration, pharmacological therapy for DM (use of insulin) * diabetic thick skin: loss of elasticity, commonly with shiny appearance, can lead to limited joint mobility and contractures, more common in hands and fingers, usually dorsum, overall thickening
88
changes in skin and nails with diabetes
* **diabetic yellow skin**: yellow nails and skin discoloration, usually on palms of hands or soles of feet * **diabetic dermopathy**: most common cutaneous change, present in 30-60% of patients with DM, usually seen in men > 50 YO * presents as round/oval atrophic, hyperpigmented raised lesions, usually on pretibial area of LEs * **xerosis**: 75-82% had dryness of the skin with fissures/cracks, most common on heels and feet, increased risk of infection * **acanthosis nigricans**: development of dark, thick, velvety skin in body folds and creases, can indicate benign and malignant conditions, common in axilla, groin, posterior neck * **acquired perforating dermatosis**: large papules with central keratin plugs, usually on LEs * **vitiligo**: progressive, 1-7% of pts with DM * **nail changes**: thickening, yellowing, red/borwn/black discoloration, green, whitening of entire nail or transverse white bands, toenail deformities
89
cutaneous reactions to insulin
* lipoatrophy: occurs within 6-24 months of starting treatment, most common in children and women * lipohypertrophy: resemble lipoma * both though to be related to repeat injection sites
90
chronic wounds
* present for at least 6 weeks * characteristics: necrotic tissue, bioburden, chornic inflammation, impaired hemodynamics, senescent fibroblasts and keratinocytes, chronic wound fluid with growth inhibiting proteases, overgrowth of epithelium with lack of underlying connective tissue (epibole)
91
90% of chronic wounds belong to 4 categories
* arterial: ischemia, micro or macro vascular disease, smoking * venous insufficiency: DVT, recent surgery, ankle fusion, prolonged standing, pregnancy, congestive heart failure * neuropathic/diabetic: diabetes, PVD, Hansen's disease * pressure: pressure or shear, immobility, moisture, decreased sensation, poor nutrition
92
neuropathic wounds
* occur on the foot, usually on plantar surface or toes * caused by mechanical forces or minor trauma * occur in patients wit hdiabetes or PVD, Hansen's disease, spina bifida, lupus, toxic syndromes, Chacot-Marie-Tooth * patients typically have sensory, autonomic, and motor neuropathies
93
arterial wounds
* caused by ischemia * usually located at the peripheral extremities * caused by macro- or microvascular disease * macro: obstruction of the larger named arteries by PAOD, emobolus, thrombus, trauma * micro: disease of the small unnamed arterioles and capillaries, usually associated with diabetes or small emobli
94
peripheral vascular disease (peripheral arterial occlusive disease [PAOD])
critical phases 1. collateral circulation insufficient for metabolic needs: shunting of blood to muscles where there is less resistance, delayed healing of traumatic wounds 2. claudication: pain with activity: can be effectively treated with exercise (thigh and buttock claudication - aortoiliac or iliac involvement, calf claudication - femoral or popliteal involvement 3. rest pain: requires revascularization surgery, may be accompanied by signs of ischemia at distal digits
95
arterial screening and wounds
* ABI: diminished * pulses: diminished * capillary refill time: > 3s * buergers test: elevation and rubor of dependency * skin appearance: shiny, thin, pale, no hair growth * conditoin of nails and hair * location: distal toes or fingers * wound edges: even, punched out appearance * wound tissue: dry, necrotic, little or no granulation
96
venous wounds
* relate to 70% of LE wounds * 500,000-1,000,000 in UE * 40% occur before age of 50 * recurrence rate is as high as 72% * estimated cost of care is $40k/case * superficial veins: great saphenous, small saphenous, perforator veins, lymphatic system * deep veins: femoral, popliteal
97
chronic venous insufficiency
causes * reflux as a result of incompetent valves in the perforator, superficial, or deep veins * obstruction: e.g. chronic deep vein thrombosis * lack of venous pump activation during gait cycle * results in venous hypertension and excessive moisture in the interstitial tissue * prevents adequate oxygen and nutrients from reaching the skin
98
chronic venous insufficiency - pathophysiological changes
* vessel dilation and elongation * increased collagen deposition in both vein walls and skin * plasma protein leaks into interstitial space with resulting fibrin cuff around arterioles * increased inflammatory cells resulting in tissue remodeling and dermal fibrosis
99
chronic venous insufficiency - risk factors
* history of DVT (37%) * history of hip/knee/calf surgery * ankle hypomobility/fusion * employment involving prolonged standing * morbid obesity * pregnancy * heart failure * progression: heavy, aching feeling in legs, telegentsia or reticular veins, varicose veins, edema without ulceration, skin changes without ulceration, skin changes with ulceration
100
chronic venous insufficiency - common skin changes
* hyperpigmentation (hemosiderin) * lipodermatosclerosis * dilated long saphenous vein * atrophie blanche * unilateral or bilateral edema * dermatitis * thickened skin * cellulitis * located in gaiter area
101
mixed venous and arterial wounds (MAVLU)
* presenation isn't clean for one or the other * ABI is gold standard test to determine * ABI 0.6-0.8 is "mixed ulcer * accounts for approximately 10% of LE ulcers * origin primarily due to chronic venous insufficiency with poor healing, with coexisting arterial insufficiency * pathophysiology: typically a combination of venous HTN, primary or post-thrombotic venous reflux and/or obstruction, and reduction in blood inflow due to PAOD