Wound Healing Flashcards
(22 cards)
What is deposited mostly during scar formation?
CT mostly collagen
What plays a central role in the repair process?
Macrophages
Repair Sequence: Day 1?
Neutrophils migrate in and phagocytose foreign substances and necrotic tissues
Repair Sequence: Day 2?
Macrophages enter
Granulation tissue (capillaries and immature fibroblast)
Protected by Fibrin clot
Repair Sequence: Day 3-6?
Lymphocytes and plasma cells
Repair Sequence: Day 7?
Clot digested, initial repair complete
Repair Sequence: Day 14?
Fibroblast mature, collagen remodeled, scar tissue
When is regeneration not possible (2 things)?
Permanent Tissues
Extensive ECM damage
What does fibrosis mean?
Excessive scar tissue, often seen in chronic inflammation
What makes fibroblast growth factor (FGF)?
Macrophages
Migration and proliferation of fibroblast is mediated by what?
FGF
Migration and proliferation of fibroblast and smooth muscle cells is mediated by what?
PDGF (platelet derived growth factor)
What does Vascular endothelial growth factor mediate (VGEF)?
New blood vessels
What day does granulation tissue typically appear?
Day 3-5
What mediates fibroblast depositing collagen?
TGF-B
What stimulates production of collagen and inhibits breakdown of ECM proteins (anti-inflammatory)?
TGF-B
What degrades ECM proteins?
Matrix Metalloproteinases
What is a part of the remodeling process?
Matrix Metalloproteinases
What inhibits Matrix Metalloproteinases?
tissue inhibitors of metalloproteinases (TIMPs)
IL-___ stimulate collagen synthesis and fibroblast migration
13
IL-13 stimulates two things?
Collagen synthesis
Fibroblast migration
What is released as inactive precursors and then activated by proteases at the site of injury? They will degrade ECM proteins.
Matrix Metalloproteinases
