Wound Healing, cihangir

Question 1

Which stage is the longest stage in wound healing?

Answer 1

Maturation

Question 2

Which stage is the last stage in wound healing?

Answer 2

Maturation 4th stage

Question 3

How long does maturtion stage lasts?

Answer 3

6-12 months

Question 4

During which period is the serine proteases and matrix metalloproteases most active?

Answer 4

Maturation

Question 5

What happens in kelloid scar and why does it over mature?

Answer 5

Bcz there’s an error in the maturation process specifically serine proteases and matrix matalloproteases is not working

Question 6

How do you differentiate b/w Keloid scar and hypertrophic scar?

Answer 6

Keloid scar: exceeds the original wound limit; painful

Hypertrophic scar: develops within the borders of the wound; can form anywhere

Question 7

Which layer in the skin has the highest tensile strength and suture holding capacity?

Answer 7

Submucosa

Question 8

The early strength of the anastomosis depends on the suture holding capacity, which is predominantly in the …………?

Answer 8

Submucosa with the serosa

Question 9

Why does the GIS mucosal and serosal injuries heal without scarring?

Answer 9

Bcz they heal with contraction not epithelization

Question 10

What are the stages of wound healing?

Answer 10

1-hemostasis
2-inflammation
3-fibroplasia
4-maturation

Question 11

How is a chronic wound distinguished?

Answer 11

-If it doesn’t get better in 3 months
-malignant transformation may be observed= MARJOLIN ULCER

Question 12

During which period of wound healing does Angiogenesis(formation of new blood vessels) decreases and fibroplasia ends?

Answer 12

Maturation

Question 13

Which one is stronger, the mechanical strength of an uninjured tissue or a scar?

Answer 13

Mechanical strength of an uninjured tissue

Question 14

during which stage of wound healing are growth factor hormones released ?

Answer 14

during Hemostasis

Question 15

*what are the proteins released during hemostasis from thrombin-activated platelets?

Answer 15

IGF-a
PDGF
TGF-a/b

Question 16

vasoconstriction is seen in which stage of wound healing?

Answer 16

hemostasis

Question 17

*what is the process of Hemostasis?

Answer 17

injury–>bleeding–>vasoconstriction–>platelets from the first plug–>coagulatıon factors–>Fibrin
[I Bleed Vaso in Platelet Plug then Coagulation occurs in Fibrin]

Question 18

during which step is the thrombin-activated platelets start secreting its proteins, and what are they?

Answer 18

during hemostasis
proteins; IGF-1, TGF-a/b, PDGF

Question 19

*what is the 5th stage in wound healing?

Answer 19

there’s no 5th stage`

Question 20

*what are the signs of inflammation?

Answer 20

1-Rubor(redness.)
2-Dolor(pain)
3-Calor(fever)
4-Tumor(swelling)

Question 21

………. release substances s.a histamine and serotonin that increase ……………..

Answer 21

Mast cells
increase vascular permeability

Question 22

which stage of wound healing is characterized by the migration of leukocytes into wound?

Answer 22

2-inflammation

Question 23

………………. are the first to arrive at the wound site

Answer 23

Polymorphonuclear neutrophils (PMNs) [are the most abundant innate immune cells in the body and act as the first defense against infections]

Question 24

macrophage function in wound healing?

Answer 24

-secreted during inflammation
-2nd inflamm cell secreted
-fibroplastic proliferation
-phagocytosis of wound cell debris

Question 25

***what is the function of T lymphocytes during inflammation step?

Answer 25

-peaks around 1 week after injury -they bridge the *transition from inflammation to proliferation*

Question 26

during which period is collagen synthesized?

Answer 26

fibroplasia/proliferation

Question 27

the time b/w the injury and the onset of collagen in the healing wound is called the ..........

Answer 27

lag phase; in proliferation step

Question 28

how long does it take for epithelialization to be completed in primary closure wounds?

Answer 28

48 hrs

Question 29

which mech plays a role in the repair of full-thickness injuries s.a in tubular organs (bile duct, esophagus, colon)?

Answer 29

contraction

Question 30

which mech plays a role in the repair of injuries that are not full-thickness s.a in skin or mucosa?

Answer 30

epithelialization

Question 31

wound contraction is provided by ............?

Answer 31

myofibroblasts

Question 32

are those local or systemic factors affecting wound healing? mechanical injury infection edema

Answer 32

local

Question 33

are those local or systemic factors affecting wound healing? ischemia topical agents ionizing radiation low O2 pressure foreign body

Answer 33

local

Question 34

are those local or systemic factors affecting wound healing? age nutrition trauma metabolic diseases immunosuppression

Answer 34

systemic

Question 35

are those local or systemic factors affecting wound healing? connective tissue disease smoking drugs

Answer 35

systemic

Question 36

are those local or systemic factors affecting wound healing? mineral deficiency vitamin deficiency

Answer 36

systemic