Wound Repair Flashcards
(45 cards)
List common causes of superficial wounds.
- lacerations
- bites
- small burns
- puncture wounds
- abrasions
3 Goals of Wound Care
- eliminate complications
- restore function (check tendon and nerve status)
- reduce scarring as much as possible
Steps in Good Wound Care
- cleansing
- hemostasis
- anesthesia
- wound irrigation and exploration
- removal of devitalized tissue
- tissue preservation
- closure tension, deep sutures if necessary
- tissue handling during closure
- dressing
- F/U
3 Stages of Wound Healing
- inflammatory phase
- proliferative phase: epithelialization, neovascularization, collagen synthesis
- remodeling: wound contraction and remodeling, scar management
Inflammatory Phase
- usually 1-5 days
- begins with hemostasis
- granulocytes released to wound followed by lymphocytes and immunoglobulins
- function is to control bacterial growth and suppress infection
- often resembles purulence/pus
Proliferative Phase I: Epithelialization
- inflammatory response ongoing
- w/in 24 hours, intact cells at wound edge replicate
- forms pseudopod like structures that facilitate cell migration and res-establish normal epidermis layers
- most evident days 5-14
Proliferative Phase II: Neovascularization
- new vessel formation crucial to wound repair and healing by replacing old, injured network and O2/nutrient delivery to healing wound
- evident by day 3, most active day 7
- gives erythematous appearance to wound
- new vessels = loops of capillaries –> granulation
Proliferative Phase III: Collagen Synthesis
- rapid mitosis of fibroblasts due to establishment of vascular supply and macrophage stimulation results in new collagen fibril production
- begins day 2, peaks day 5-7
- greatest collagen mass by 3 weeks
- random amorphous gel –> little tensile strength
- final tensile strength takes several months
Remodeling Phase I: Wound Contraction and Remodeling
- wounds continue remodeling over several months
- some degree of contraction occurs where normal surrounding skin is pulled over the defect
- scar changes in appearance with remodeling
- final appearance may take 6-12 months
Remodeling Phase II: Scar Management and Revision
- if final scar is unacceptable, multiple options for revision: cryotherapy, pressure dressings, dermabrasion, radiation, intralesional corticosteroids
- important to identify pts with hx of keloids/hypertrophic and refer to skilled specialists after initial repair
What chronic medical conditions might interfere with healing?
- advanced age
- EtOHism
- acute uremia
- severe anemia
- malnutrition
- diabetes
- peripheral vascular disease
What technical factors might interfere with healing?
- inadequate wound prep
- excessive suture tension
- reactive suture materials
- local anesthetics
What anatomic factors might interfere with healing?
- skin tension
- pigmented skin
- oily skin
- location of wound
What drugs/meds might interfere with healing?
- corticosteroids
- NSAIDs
- penicillin
- beta blockers (coumadin, plavix)
- anticoagulants
- colchicines
- antineoplastic agents
- tobacco
General Management of a Wound
- ABCs
- control hemorrhage
- pain relief
- abx/Tdap vaccine if necessary
- wound evaluation
- wound management
- consultation
What are some important pieces of information to gather in H&P for a patient with a wound?
- MOI: what happened, presence of foreign body, possibility of tendon injury
- age of wound: imp when deciding how to treat (6 hour suture?)
- underlying disorders
- prior healing
- allergies
- last tetanus
- interval for suture removal (depends on body region and other factors)
Why is it important to not put betadine in a wound?
causes tissue necrosis
What variables affect choice of anesthesia?
- type of wound
- location of wound
- estimated repair time
What reactions can occur with local anesthetic?
- cardiovascular reactions
- excitatory CNS effects
- vasovagal syncope secondary to pain/anxiety (common, esp with kids)
3 Most Commonly Used Anesthetics for Local Infiltration and Nerve Blocks
- lidocaine/xylocaine
- mepivacaine
- bupivicaine
Lidocaine
- most commonly used
- rapid onset 4-10 minutes
- good tissue preserving properties
- duration for nerve block: 60-120 minutes
- lidocaine w/ epi increases duration and reduces bleeding
When is use of epi with lidocaine contraindicated?
DO NOT USE ANESTHETICS WITH EPI IN ANATOMICAL AREAS WITH TERMINAL CIRCULATION (aka fingers, toes, ears, penis, nose)
Mepivicaine
- widely used in ED
- 6-10 min onset
- duration 30-60 min for simple blocks, 90-180 mins for nerve blocks
- less vasoconstricting effect than lidocaine so does not require addition of epi
Bupivicaine/Marcaine
- becoming more popular
- effective but slower onset 8-12 min
- LOOOONG duration 240-480 mins (4-8hrs)
- can be combined with lidocaine