WSAVA Flashcards
(30 cards)
Some infectious vaccines are administered
directly to mucosal sites (i.e. __/__vaccines) where they are even more effective at inducing relevant protective mucosal immunity.
intranasal or oral
live vector organism carrying genetic material encoding an antigen from the target pathogen
recombinant vectored vaccines
When administered to an animal that lacks maternally-derived antibody (MDA) an infectious vaccine will generally induce protec- tion with a _- dose.
singl
generally require an adjuvant to increase their potency and usually require multiple doses (even in an adult animal) to induce protection.
non-infectious vaccine
Route of admin for non-infec vacc
parenteral
use is determined on the basis of the geographical and lifestyle exposure risks of the indi- vidual and an assessment of risk–benefit ratios
non-core vaccines
, passive immunity will have waned by __ weeks of age to a level that allows active immunization.
8-12 wks
Puppies with poor MDA may be vulnerable (and capable of responding to vaccina- tion) at an earlier age, while others may possess MDA at such high titres that they are incapable of responding to vaccination until -_ weeks of age
≥12
a single primary vaccination policy can cover all possible situations.
f
The recommendation of the VGG is for initial core vaccination at _- weeks of age, then every 2–4 weeks until __ weeks of age or older.
6–8
16
of age. The rationale behind this protocol is to permit ‘___’ of puppies while diminishing the risk of infectious diseases. The VGG recognizes that early socialization is essential to the behavioural development of dogs
early socialization
The VGG recommends that whenever possible the last of the puppy primary series of core vaccines be given at __ weeks of age or older
16
An integral part of core vaccination of puppies is the
‘booster’ vaccine
The main aim of this vaccine is to ensure that a protective immune response develops in any dog that may have failed to respond to any of the vaccines in the primary core series, rather than necessarily ‘boosting’ the immune response.
booster vacc
the VGG has re-evaluated this practice and now suggests that veterinarians might wish to reduce this possible window of susceptibility by bringing forward this vaccine from ___ of age (or indeed at any time point between __ weeks of age; however,__ weeks of age provides a convenient timing).
52 weeks to 26 weeks
26-52
26
Dogs that have responded to vaccination with MLV core vaccines maintain a solid immunity (immunological memory) for many years in the absence of any repeat vaccination
t
on adult dogs, Following the 26 or 52 week booster, subsequent revaccinations are given at intervals of _ years or longer.
3
An adult dog that had received a complete course of core vaccinations as a puppy, including a 26 or 52 week booster, but that may not have been vaccinated regularly as an adult, requires how many doses of MLV core vacc/
1
‘gold standards’ for serological testing
virus neutralization and haemagglutination inhibition test
A__ test result indicates that the dog has little or no antibody, and that revaccination is recommended.
negative
a positive test result would lead to the conclusion that __
revaccination is not required.
protective rabies antibody titre
> 0·5 IU/ml
A serum sample taken at least - weeks after the final vaccination may be tested.
4
why should the serum titres be tested at least 4 weeks after last vaccination
This interval will ensure that MDA is no longer present and that even ‘slow responder’ puppies have seroconverted.
