XIX - Female Genital System and the Breast Flashcards Preview

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Flashcards in XIX - Female Genital System and the Breast Deck (151)
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The combination of ovarian tumor, hydrothorax, and ascites is designated as

Meigs Syndrome (TOPNOTCH)


What type of ovarian cancer is best considered as the counterpart of the seminoma of the testes?

Dysgerminoma (TOPNOTCH)


About 1% of the dermoids undergo malignant transformation of any one of the component elements present, but most commonly, they differentiate into what type of carcinoma?

Squamous Cell Carcinoma (TOPNOTCH)


Morphology: epithelial component consists of nests of transitional cells resembling the lining of the urinary bladder

Brenner Tumor (TOPNOTCH)


Morphology: characterized by a lining of tall columnar epithelial cells with apical mucin and the absence of cilia, resembling cervical or intestinal epithelium

Mucinous tumors (TOPNOTCH)


Morphology: lined by a rim of bright yellow luteal tissue containing luteinized granulosa cells

Luteal cyst (TOPNOTCH)


Morphology: characterized chiefly by dilations of ducts, inspissation of breast secretions, and marked periductal and interstitial chronic granulomatous reaction

Mammary Duct Ectasia (TOPNOTCH)


What are the 3 principal patterns of morphologic changes seen in Fibrocystic Changes of the breast?

1. Cyst formation with apocrine metaplasia2. Fibrosis3. Adenosis (TOPNOTCH)


Morphology: "leaflike" architecture

Phyllodes Tumor (TOPNOTCH)


Morphology: proliferation of intralobular stroma surrounding and often pushing and distorting the associated epithelium. The border is sharply delimited from the surrounding tissue

Fibroadenoma (TOPNOTCH)


What is the most important prognostic factor useful as a predictive factor for the response of therapy in patients with breast cancer?

Presence of estrogen and progesterone receptors (TOPNOTCH)


In breast cancer, what is the most important prognostic factor for invasive carcinoma in the absence of distant metastases?

Lymph node metastases (TOPNOTCH)


Morphology: tumor cells are prsent as small clusters within large pools of mucin

Mucinous colloid carcinoma (TOPNOTCH)


Morphology: characterized by solid syncytium like sheets occupying 75% of the tumor , prominent lymphoplasmacytic infiltrate and a non inflitrative border

Medullary carcinoma of the breast (TOPNOTCH)


The histologic hallmark of this tumor is the pattern of single infiltrating tumor cells, often only one cell in width, or in loose clusters or sheets

Invasive lobular carcinoma (TOPNOTCH)


This is a rare manifestation of breast cancer and presents as a unilateral erythematous eruption with a scale crust

Paget disease (TOPNOTCH)


These are stellate lesions characterized by a central nidus of entrapped glands in a hyalinized stroma

Complex Sclerosing Lesion or Radial Scar (TOPNOTCH)


Morphology: composed of multiple branching fibrovascular cores, each having a connective tissue axis lined by luminal and myoepithelial cells

Papillomas (TOPNOTCH)


What is the most common clinical presentation of breast disease



The principal mammographic signs of breast carcinoma

densities and calfications (TOPNOTCH)


Morphology: the main histologic feature is keratinizing squamous epithelium extending to an abnormal depth into the orifices of the nipple ducts

Periductal mastitis (TOPNOTCH)


Mammographic appearance: Large lobulated "popcorn" calcifications

Fibroadenoma (TOPNOTCH)


Morphology: characterized by solid sheets of pleomorphic cells with high-grade nuclei and central necrosis detected mamographically as clusters or linear and branching microcalcifications

Comedocarcinoma (TOPNOTCH)


Morphology: Terminal ducts (without lobule formation) are lined by a multilayered epithelium with small papillary tufts and surrounding periductal hyalinization and fibrosis.

Gynecomastia (TOPNOTCH)


Morphology: terminal duct lobular unit is enlarged, and the acini are compressed and distorted within the lumens. Calcifications are often present within the lumens.

Sclerosing adenosis(TOPNOTCH)


Morphology: central fibrovascular core extends from the wall of a duct. The papillae arborize within the lumen and are lined by myoepithelial and luminal cells

Intraductal papilloma(TOPNOTCH)


Cellular proliferation resembling ductal carcinoma in situ or lobular carcinoma in situ but lacking sufficient qualitative or quantitative features for a diagnosis of carcinoma in situ

Atypical hyperplasia(TOPNOTCH)


Refers to a proliferation of cells identical to those of LCIS but the cells do not fill or distend more than 50% of the acini within a lobule.

Atypical Lobular hyperplasia(TOPNOTCH)


Recognized by its histologic resemblance to ductal carcinoma in situ, including a monomorphic cell population, regular cell placement, and round lumina. However, the lesions are characteristically limited in extend, and the cells are not completely monomorphic in type or they fail to completely fill ductal spaces

Atypical hyperplasia(TOPNOTCH)


What are the two major risk factors for breast carcinoma?

Hormonal and Genetics/family history(TOPNOTCH)