Flashcards in XIX - Female Genital System and the Breast Deck (173)
A cystic dilation of an obstructed duct that arises during lactation.
Galactocele (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739
Multifocal, bilateral blue-brown cysts ("blue dome cysts") of the breast, measuring 1-5 cm diameter, filled with serous turbid fluid. Occurs normally in the menstrual cycle.
Simple fibrocystic change of the breast(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739
Term used to describe hyperplasia that cytologically resemble lobular carcinoma in situ, but the cells do not fill or distend more than 50% of the acini within a lobule.
Atypical lobular hyperplasia (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739
The lumen of the ducts, ductules, or lobules of the breast is filled with a heterogeneous population of cells of different morphologies. Irregular slit-like fenestrations are prominent at the periphery.
Epithelial Hyperplasia (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 739
These lesions are characterized by proliferation of lining epithelial cells and myoepithelial cells in small ducts and ductules, yielding masses of small gland patterns within a fibrous stroma. The acini are arranged in a swirling pattern, and the outer border is usually well circumscribed.
Sclerosing Adenosis (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 741
A nonbacterial chronic inflammation of the breast associated with inspissation of breast secretions in the main excretory ducts.
Mammary duct ectasia (periductal or plasma cell mastitis) (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742
The most common benign neoplasm of the female breast.
Fibroadenoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742
A discrete, usually solitary, freely movable nodule, 1 to 10 cm in diameter, easily "shelled out" lesion of the breast. Histologically there is a loose fibroblastic stroma containing ductlike, spaces lined by a layer of epithelium that are regular and have a well-defined, intact basement membrane.
Fibroadenoma (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 742
A type of noninvasive carcinoma of the breast that tends to fill, distort, and unfold involved lobules and thus appears to involve ductlike spaces.
Ductal Carcinoma in Situ(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 745
A type of noninvasive carcinoma of the breast expands but does not alter the underlying lobular architecture. cells are monomorphic with bland, round nuclei and occur in loosely cohesive clusters in ducts and lobules. Tend to be bilateral, and increases risk for development of breast CA.
Lobar Carcinoma in Situ(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 746
Morphology: large macrophages with granular PAS positive cytoplasm and several dense, round Michaelis Gutmann bodies.
In gonococcal infection of the female reproductive system, inflammatory changes will appear about how many days after the inoculation of the organism?
2-7 days (TOPNOTCH)
These cells are distinguised by a clear separation "halo" from the surrounding epithelial cells and a finely granular cytoplasm containing mucopolysaccharide that stains with PAS, Alcian Blue, and Mucicarmine
Paget cells (TOPNOTCH)
What is the probable precursor of vaginal adenocarcinoma?
Vaginal adenosis (TOPNOTCH)
What do you call the glandlike structures filled with an acidophilic material similar to immature follicles that are seen in Granulosa Theca Cell tumors?
Call Exner bodies (TOPNOTCH)
Presence of these structures characterize serous tumors of the ovaries
Psammoma bodies (TOPNOTCH)
These tumors are distinguished from serous and mucinous tumors of the ovaries by the presence of tubular glands that resemble the endometrium
Endometriod tumor (TOPNOTCH)
A key factor in the development of endometrial hyperplasia and related cancers is the inactivation of what tumor suppressor gene?
What is the most common location of vaginal adenocarcinoma?
Anterior wall of the upper third of Vagina (TOPNOTCH)
This is a condition in which glandular columnar epithelium of mullerian type either appears beneath the squamous epithelium or replaces it
Vaginal Adenosis (TOPNOTCH)
What are the 4 cardinal histologic features of Lichen Sclerosus of the Vulva or Chronic atrophic vulvitis?
Atrophy of the epidermis with disappearance, of the rete pegs, hydrophic degeneration of the basal cells, replacement of the underlying dermis by dense collagenous fibrous tissue, and monoclonal band like lymphocytic infiltrate (TOPNOTCH)
Morphology: acanthosis of the vulvar squamous epithelium frequently with hyperkeratosis
Lichen SImplex Chronicles (TOPNOTCH)
Morphology: presence of large tumor cells lying singly or in small lusters within the epidermis and its appendages
Extra mammary Paget Disease (TOPNOTCH)
Morphology: tumor cells resemble tennis racket with small protrusions of cytoplasms from one end
Embryonal Rhabdomyosarcoma (TOPNOTCH)
Clustering of tumor cells in a so called "Cambium Layer" is seen in what type of rhabdomyosarcoma?
Embryonal Rhabdomyosarcoma (TOPNOTCH)
On histological examination of the cervix, epithelial spongiosis is associated with what type of infection?
T. vaginal infection (TOPNOTCH)
On histological examination of the cervix, epithelial ulcers with intranuclear inclusions within the epithelial cells and lymphocytic infiltration is associated with what type of infection?
Morphology: these are composed of dense fibrous stroma covered with endocervical columnar epithelium
Endocervical polyp (TOPNOTCH)
What is considered the most important agent in cervical oncogenesis?