XIX - Female Genital System and the Breast (with pics) Flashcards Preview

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1

Lesion of the female vulva characterized by thinning of the epidermis and disappearance of rete pegs, hydropic degeneration of basal cells, superficial hyperkeratosis, dermal fibrosis with scant perivascular, mononuclear inflammatory cell infiltrate. Occurs most commonly in postmenopausal women. SEE SLIDE 19.1

Lichen sclerosus(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 713

2

This disorder of the vulva is marked by epithelial thickening, expansion of the stratum granulosum, significant surface hyperkeratosis and pronounced leukocytic infiltrate. Appears clinically as an area of leukoplakia. SEE SLIDE 19.2

Lichen simplex chronicus(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 713

3

These are flat, moist, minimally elevated lesions that occur in secondary syphilis.

Condyloma lata(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 713

4

Lesions of the anogenital area which may be papillary and distinctly elevated or may be somewhat flat and rugose. Characteristic cellular morphology is the presence of cytoplasmic vacuolization with nuclear angular polymorphism and koilocytosis. SEE SLIDE 19.3. Hallmark of HPV infection.

Condyloma acuminata(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 713

5

Red, scaly plaque, microscopically characterized by the spread of malignant cells within the epithelium, occasionally with invasion of underlying dermis. May have underlying carcinoma of a vulvar or perineal gland.

Paget disease of the Vulva(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 715

6

A soft polypoid mass, which is a rare form of primary vaginal cancer. SEE SLIDE 19.4. Usually encountered in infants and children less than 5 y/o.

Sarcoma botryoides (embryonal rhabdomyosarcoma)(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 716

7

Most commonly develops in the transformation zone of the cervix. Produces a "barrel cervix" if the tumor encircles the cervix and invades the underlying stroma.

Invasive carcinoma of the cervix(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 719

8

Protruding polypoid masses which are inflammatory in origin, soft, yields to palpation, and have a smooth, glistening surface with underlying cystically dilated spaces filled with mucinous secretion.

Endocervical polyp(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 721

9

Refers to the growth of the basal layer of the endometrium down to the myometrium. Nests of endometrial stroma, glands or both are found in the myometrium, in between muscle bundles. SEE SLIDE 19.5.

Adenomyosis(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 721

10

Characterized by the presence of endometrial glands and stroma in a location outside the endomyometrium. Undergoes cyclic bleeding. Also called "chocolate cysts". SEE SLIDE 19.6.

Endometriosis(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 722

11

These are sharply circumscribed, firm, gray-white masses of the uterus, with "whorled" cut surface. Histologically, it shows bundles of smooth muscle cells mimicking the appearance of normal myometrium.

Leiomyoma. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p 693

12

Solitary tumors of the uterus which arise de novo from the mesenchymal cells of the myometrium. Characterized by the presence of tumor necrosis, cytologic atypia and mitotic activity.

Leiomyosarcomas. (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 725

13

Type of endometrial carcinoma associated with estrogen excess and endometrial hyperplasia.

Endometroid carcinoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 727

14

Type of endometrial carcinoma which occurs in older women and is usually associated with endometrial atrophy.

Serous carcinoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 727

15

Small, fluid-filled cysts which originate from the unruptured graafian follicles or in follicles that have ruptured and immediately sealed.

Follicle and luteal cysts(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 728

16

Triad of oligomenorrhea, infertility and obesity in young women secondary to excessive production of estrogens and androgens.

Polycystic ovaries(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 728

17

Other name for polycystic ovary syndrome?

Stein-Leventhal syndrome(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 728

18

Two most important risk factors for development of ovarian cancer.

Nulliparity and family history(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 729

19

Mutation of this gene is associated in the development of both ovarian and breast cancers.

BRCA 1(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 729

20

Mutation of this gene is associated with the development of breast cancer only

BRCA 2(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 729

21

Benign lesion of the ovary most commonly seen in women 30-40 years old. Most frequent of the ovarian tumors. Serosal covering is smooth and glistening. Characterized histologically by tall, columnar epithelium and the presence of Psammoma bodies. SEE SLIDE 19.7

Serous tumor of the ovary(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 730

22

Large, multilocular tumors of the ovaries, without psammoma bodies. Composed of mucin-producing epithelial cells.

Mucinous Tumors (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 731

23

Metastasis of mucinous tumor of the gastrointestinal tract to the ovaries is called?

Krukenberg tumor. SEE SLIDE 19.24. Usually bilateral, as opposed to mucinous tumors of primarily ovarian origin. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p 698

24

A rare, solid, unilateral ovarian tumor consisting of an abundant stroma containing nests of transitional-like epithelium resembling that of the urinary tract. SEE SLIDE 19.8

Brenner Tumor (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

25

Unilateral ovarian tumor composed of sheets or cords of large cleared cells separated by scant fibrous strands. Stroma may contain lymphocytes and occasional granuloma. Usually occur on the 2nd-3rd decade of life. SEE SLIDE 19.9

Dysgerminoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

26

Unilateral ovarian tumor which occur during the 1st 3 decades of life. Characterized by small, hemorrhagic focus with syncitiothrophoblast and cytotrophoblast. Metastasize early. SEE SLIDE 19.10

Choriocarcinoma(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

27

Sex cord tumor seen as small, gray to yellow-brown, and solid lesions. May resemble development of testis with tubules, or cords and plump pink Sertoli cells. May be masculinizing or defeminizing.

Sertoli-Leydig cell tumor(TOPNOTCH) Robbins Basic Pathology, 8th ed., p 732

28

Microscopically, the distinguishing feature is a variety of immature or barely recognizable areas of differentiation toward cartilage, bone, muscle, nerve, and other structures. Found early in life.

Immature Malignant Teratomas (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 733

29

Tumor of the ovary composed entirely of mature thyroid tissue. May hyperfunction and produce hyperthyroidism. Appear as small, solid, unilateral brown ovarian masses. SEE SLIDE 19.11

Struma ovarii (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 733

30

A voluminous mass of swollen, sometimes cystically dilated, chorionic villi, appearing grossly as grapelike structures. SEE SLIDE 19.12

Hydatidiform Mole (TOPNOTCH) Robbins Basic Pathology, 8th ed., p 735