Flashcards in XV - The Oral Cavity and the GI Tract Deck (141)
What are the two key pathogenic abnormalities seen in Idiopathic Inflammatory Bowel disease?
Strong immune response against normal flora and defects in epithelial barrier function(TOPNOTCH)
Gross morphology: intestinal wall is rubbery and thick, as a consequence of edema, inflammation, fibrosis and hypertrophy of the muscularis propria
Morphology: small intestinal mucosa laden with distended macrophages in the lamina propria which are PAS positive and contains numerous bacilli and diastase resistant granules
Intestinal lipodystrophy is associated with what disease entity?
Morphology: diffuse severe atrophy and blunting of villi, with a chronic inflammatory infiltrate in the lamina propria
Morphology: focal crypt cell necrosis or apoptosis with minimal to absent inflammatory cell response in the lamina propria
Morphology: marked blunting of the small intestinal villi with a mixed inflammatory infiltrate resembling the atrophic stage of celiac disease
Morphology: superficial erosion of the mucosa and an adherent pseudomembrane of fibrin, mucus, and inflammatory debris
Morphology: small intestinal mucosa usually exhibits modestly shortened villi and infiltration of the lamina propria by lymphocytes
What virus affecting the GIT can produce a flat mucosa resembling celiac sprue?
Morphology: characterized by the absence of ganglion cells and ganglia in the muscle wall and submucosa of the affected segment
Congenital Aganglionic Megacolon(TOPNOTCH)
Stercoral ulcers are seen in what disease entity?
Congenital aganglionic megacolon(TOPNOTCH)
The majority of these tumors are positive for c-KIT (CD 117)
Gastrointestinal Stromal Tumor(TOPNOTCH)
What is the most common site of gastric carcinoma?
Pylorus and anthrum 50%-60%(TOPNOTCH)
What is the most favored site of gastric carcinoma?
lesser curvature of the anthropyloric region(TOPNOTCH)
What is the morphologic feature of gastric carcinoma that has the greatest impact on clinical outcome?
Depth of invasion(TOPNOTCH)
This is a variant of gastric carcinoma composed of neoplastic intestinal glands resembling those of colonic adnocarcinoma and the neoplastic cells contain apical mucin vacuoles and abundant mucin may be present in gland lumens
This is a variant of gastric carcinoma which is composed of gastric type mucous cells, which generally do not form glands, but rather permeate the mcosa and wall as scattered individual cells or small clusters in an infiltrative growth pattern
What is the most common type of gastric polyp?
In gastritis, histologically, what signifies an active inflammation?
Presence of neutrophils above the basement membrane.(TOPNOTCH)