XV - The Oral Cavity and the GI Tract Flashcards Preview

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Flashcards in XV - The Oral Cavity and the GI Tract Deck (224)
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31

Defined as the replacement of the normal distal stratified squamous mucosa by metaplastic columnar epithelium containing goblet cells. A complication of long-standing GERD.

Barrett esophagus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 591

32

Esophageal lesion at risk of developing adenocarcinoma:Reflux esophagitis or Barrett esophagus?

Barrett esophagus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 589

33

Squamous cell carcinoma of the esophagus commonly occur at which segment of the esophagus?

Proximal 2/3 of the esophagusAdenocarcinoma- distal 1/3(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 591

34

Most common symptoms of esophageal cancer.

Dysphagia and odynophagia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 591

35

Mucin-producing glandular tumors of the distal esophagus showing intestinal-type features.

Adenocarcinoma of the esophagus(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 591

36

Presence of chronic inflammatory changes in the mucosa of the stomach eventually leading to mucosal atrophy and epithelial metaplasia.

Chronic gastritis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 592

37

Most important etiologic association with chronic gastritis. A non-invasive, non-spore forming S-shaped gram negative rod.

Helicobacter pylori(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 592

38

Gastritis resulting from production of autoantibodies to the gastric gland parietal cells, leading to gland destruction and mucosal atrophy with loss of acid and intrinsic factor.

Autoimmmune gastritis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 592

39

Refers to the replacement of gastric epithelium with columnar and goblet cells of intestinal variety.

Intestinal metaplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 592

40

A acute mucosal inflammatory process of the stomach, marked by mucosal edema and inflammatory infiltrate of neutrophils and chronic inflammatory cells. Regenerative replication of cells in the gastric pit is prominent.

Acute gastritis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 593

41

One of the major causes of hematemesis, especially in alcoholics.

Acute gastritis(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 593

42

A breach in the mucosa that extends through the muscularis mucosae into the submucosa or deeper.

Ulcers(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 593

43

Breach in the epithelium of the gastrointestinal mucosa only.

Erosions(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 593

44

Chronic, solitary lesions that occur in any portion of the GIT exposed to the aggressive action of acidic peptic juices.

Peptic ulcers(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 594

45

Major cause of peptic ulcer disease in patients without H. pylori disease.

NSAID use(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 595

46

Histologic layers in a chronic, nonperforated, open ulcer.

From luminal surface:NecrosisInflammationGranulation tissueScar(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 596

47

Chief complication of peptic ulcer.

Bleeding(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 596

48

Increases risk of developing gastric adenocarcinoma:Acute gastritis vs. peptic ulcer disease?

Acute gastritisPUD is NOT a premalignant lesion(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 596

49

Acute gastric ulceration which occurs in the presence of extensive burns.

Curling ulcer(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 596

50

Acute gastric ulceration which occurs in the presence of injury to the CNS.

Cushing ulcer(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 596

51

Composed of hyperplastic gastric mucosal epithelium and an inflamed edematous stroma. A mass lesion arising from the mucosa.

Gastric polyp(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 597

52

Most common site of gastric carcinoma within the stomach.

Pylorus and antrum (50-60%), along the lesser curvatureCardia (25%)(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 598

53

What are the two most important factors in the genesis of colonic diverticula?

Focal weakness in the colonic wall and increased intraluminal pressure(TOPNOTCH)

54

Morphologic feature of gastric carcinomas with greatest impact on prognosis.

Depth of invasion(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

55

Gastric carcinoma confined to the mucosa and submucosa, regardless of the presence or absence of perigastric LN metastasis.

Early gastric carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

56

Gastric carcinoma which has extended below the submucosa into the muscular wall.

Advanced gastric carcinoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

57

Three macroscopic growth patterns of gastric carcinoma.

Exophytic - protrusion of mass into lumenFlat or depressed - no obvious tumor mass within the mucosaExcavated - a shallow or deeply eroded crater(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

58

Rigid and thickened stomach, secondary to extensive malignant infiltration.

Linitis plastica(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

59

Histologic classification of gastric carcinoma composed of malignant cells forming neoplastic intestinal glands resembling colonic adenocarcinoma. Associated with H. pylori induced chronic gastritis.

Intestinal variant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599

60

Histologic classification of gastric carcinoma composed of gastric-type mucous cells that do not form glands but permeate the mucosa and wall as "signet-ring" cells in an infiltrative growth pattern.

Diffuse variant(TOPNOTCH)Robbins Basic Pathology, 8th Ed p. 599