xVitamin chart

Question 1

thiamine-cofactor

Answer 1

TPP (thiamine phosphate)

Question 2

thiamine-disease

Answer 2

beriberi/wernicke-kosakoff

Question 3

thiamine-vitamin #

Answer 3

B1

Question 4

thiamine-typical reaction

Answer 4

decarboxylase of alpha keto-acids aldehyde transfer, transketolase
(pyruvate –> Acetyl CoA

Question 5

Riboflavin-Vitamin#

Answer 5

B2

Question 6

Riboflavin-cofactor

Answer 6

FAD/FMN

Question 7

Riboflavin-disease

Answer 7

Deficiency rare in US chronic Alcoholics- glossitis, sebborrhea

Question 8

Riboflavin_typical reaction

Answer 8

oxidation reduction

succinate–>fumarate

Question 9

Pyridoxine-vitamin #

Answer 9

B6

Question 10

Pyridoxine-cofactor

Answer 10

PLP

Question 11

Pyridoxine-disease

Answer 11

deficiency rare-

peripheral neuropathy, microcytic anemia - delta ALA synth.

Question 12

Pyridoxine-typical reaction

Answer 12

group transfer:
glycogen phosphorylase transaminations
Glutamate–>ketoglutarate
(aa catabolism/synth)

Question 13

Nicotinic Acid-A.K.A.

Answer 13

Niacin

Question 14

Nicotinic Acid-vitamin #

Answer 14

B3

Question 15

Nicotinic Acid-cofactor

Answer 15

NAD

Question 16

Nicotinic Acid-disease

Answer 16

pellagra(3D’s)

diarrhea,dermatitis,dementia

Question 17

Nicotinic Acid-typical rxn

Answer 17

oxidation-reduction

malate–>OAA

Question 18

Biotin-vitamin #

Answer 18

B7

Question 19

Biotin-cofactor

Answer 19

Biotin

Question 20

Biotin-disease

Answer 20

Dermatitis, enteritis

raw egg white consumption

Question 21

Biotin-typical rxn

Answer 21

Carboxylation-
pyruvate–>OAA
Acetyl CoA–>malonyl CoA

Question 22

Vitamin C-A.K.A

Answer 22

ASCORBIC ACID

Question 23

Vitamin C-cofactor

Answer 23

ASCORBIC ACID

Question 24

Vitamin C-disease

Answer 24

Scurvy-easily bruised, poor wound healing, hemmorrhaging

Question 25

Vitamin C-tyipical rxn

Answer 25

Hydroxylation of proline and lysine in collagen or Dopamine Hydroxylase Pro-->4hydroxy-Pro or Dopamine-->NE

Question 26

Vitamin D-cofactor

Answer 26

calcitrol

Question 27

Vitamin D-disease

Answer 27

Rickets-osteomalacia: | inadequate bone mineralization

Question 28

Vitamin D-typical rxn

Answer 28

COntrols serum Ca 2+ w/ parathyroid hormone & calcitonin Acts like steroid causing change in gene transcription

Question 29

Cu 2+: cofactor

Answer 29

Cu 2+

Question 30

Cu 2+:disease

Answer 30

menkes-deficiency

Question 31

Cu 2+:disease

Answer 31

Wilson- copper accumulation

Question 32

Cu 2+:typical rxn

Answer 32

Electron transport, lsyl oxidation | O2--> H20

Question 33

Iron: Cofactor

Answer 33

Fe2+

Question 34

Iron: disease

Answer 34

Microcytic anemia | (heme synth dependent on iron

Question 35

Iodine:cofactor

Answer 35

I+ | iodinium required T3/T4

Question 36

Iodine:disease

Answer 36

associated with both: hyperthyroid (graves disease)-BUGGED OUT EYES hypothyroid

Question 37

Iodine:typical rxn

Answer 37

only used to make Thryoid Hormone | Tgb w/ Tyr residue + I+ -->Tgb w/T4

Question 38

Folic Acid:vitamin #`

Answer 38

B9

Question 39

Folic Acid:cofactor

Answer 39

Tetrahydrofolate-THF

Question 40

Folic Acid:disease

Answer 40

macrocytic megaloblastic anemia spina bifida (neurological symptoms rare)

Question 41

Folic Acid:typical rxn

Answer 41

deoxyuridylate-->Thymidylate | nucleotide biosynth

Question 42

Cobalamin:vitamin #

Answer 42

B12

Question 43

Cobalamin:cofactor

Answer 43

5' DEoxyadenosyl cobalmin

Question 44

Cobalamin:disease

Answer 44

macrocytic megaloblastic anemia neuropathy (pernicious anemia=deficient in intrinsic factor)

Question 45

Cobalamin:typical rxn

Answer 45

``` methyl transfer intramolecular rearrangement 2 relevant rxns in humans methylmalonyl CoA-->Succinyl CoA homocysteine + N-methyl THF--> Met + THF` ```

Question 46

Vitamin K:cofactor

Answer 46

Vitamin KH2

Question 47

Vitamin K:disease

Answer 47

hemmorrhagic syndrome=longer clotting times

Question 48

Vitamin K:typical rxn

Answer 48

carboxylation | Glu-->gama CarboxyGlu (gla)