XXII - The Skin Flashcards Preview

Pathology > XXII - The Skin > Flashcards

Flashcards in XXII - The Skin Deck (77)
Loading flashcards...

Histologic hallmark of Cutaneous T-cell Lymphoma

Presence of Sezary-Lutzner cells(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1160


Presents with small, pruritic papules to large edematous plaques, which may coalesce to form annular, linear, or arcform configurations. There is usually superficial perivenular infiltrate consisting of mononuclear cells, rare neutrophils, and eosinophils

Urticaria(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1162


Febrile form of erythema multiforme associated with extensive involvement of skin, lips and oral mucosa, conjunctiva, urethra, and genital and perianal areas, often seen in children.

Steven-Johnson syndrome(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1164


It is characterized by kertinocyte injury mediated by skin-homing CD8+ band cytotoxic T lymphocytes; presenting with diverse array of lesions.

Erythema Multiforme (TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1164


Process by which local trauma induce psoriatic lesions in susceptible individuals

Koebner phenomenon(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1165


Presents with macules and papules on an erythematous-yellow, often greasy base, in association with extensive scaling and crusting. Histologically, mounds of parakeratosis containing neutrophils and serum are present at the ostia of hair follicles(Follicular lipping)

Seborrheic dermatitis(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1166


Group of disorders caused by inherited defects in structural proteins that lend mechanical stability to the skin; common feature is a proclivity to form blisters at sites of pressure, rubbing, or trauma, at or soon after birth

Epidermolysis bullosa(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1171


Presents with urticaria and vesicles associated with scarring that are exacerbated by exposure to sunlight. The vesicles are subepidermal in location and dermis contains vessels with walls that are thickened by glassy deposits of serum proteins.

Porphyria(TOPNOTCH)Robbins Basic Pathology, 9th ed., p 1172


Presents with stages of flushing, then persistent erythema and telangiectasia, followed by pustules and papules, and lastly by permanent thickening of the nasal skin by confluent erythematous papules and prominent follicles(rhinophyma)

Rosacea(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1174


Presents with multiple lesions on the skin and mucus membranes, with predilection for the trunk and anogenital areas. Lesions are firm, often pruritic, pink to skin-colored umbilicated papules, with curd-like material which can be expressed from the central umbilication

Molluscum contagiosum(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1176


The pathogenesis of blister formation in this condition is related to bacterial production of a toxin that cleaves desmoglein 1, the protein responsible for cell-to-cell adhesion within the uppermost epidermal layers.

Impetigo(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1177


Presents as an erythematous macule and multiple pustules. As pustules break, shallow erosions from, covered with drying serum, giving the characteristic honey-colored crust

Impetigo(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1177


It has the characteristic microscopic feature of accumulation of neutrophils beneath the stratum corneum often producing a subcorneal pustule containing serum proteins and inflammatory cells.

Impetigo(TOPNOTCH)Robbins Basic Pathology, 9th ed., p. 1177


A 25 year old male presents with well-demarcated pink plaques on his elbows, scalp, and knees that have a silvery scale. A biopsy showed acanthosis, elongated rete ridges, loss of stratum granulosum with an overlying parakeratotic scale, thinning of the epidermis overlying the dermal papillae, and neutrophil aggregates in the parakeratotic stratum corneum. The dermatologist removes one of the scales, and a pinpoint bleeding is observed. This phenomenon is due to (A) the acanthosis (B) thinning of the epidermis overlying the dermal papillae (C) neutrophil aggregates (D) elongated rete ridges

thinning of the epidermis overlying the dermal papillae (TOPNOTCH)Robbins Basic Pathology, 8th ed., p 841


A 62 year old woman has a coin-like, dark brown plaque on her chest that appears stuck-on. She has it excised, and histopathology showed an orderly proliferation of basaloid cells, with keratin microcysts. Some of the basaloid cells have melanin. Her lesion (A) is a tumor of malignant melanocytes (B) is common in her age group (C) will exhibit a fishnet appearance if subjected to immunofluorescence (D) is a melanocytic nevus

is common in her age group (seborrheic keratosis) (TOPNOTCH)Robbins Basic Pathology, 8th ed., p 845848-849


A 33 year old female has multiple flesh-colored papules on her face, neck, trunk, and limbs. One of the papules is excised, which showed a lobular proliferation of sebocytes, some with vacuolated cytoplasm, others more basaloid in appearance. Her lesions may be a sign of underlying (A) colorectal carcinoma (B) nonHodgkin lymphoma (C) aplastic anemia (D) thalassemia

colorectal carcinoma (sebaceous adenoma and Muir-Torre syndrome) (TOPNOTCH)Robbins Basic Pathology, 8th ed., p 849


A 45 year old male has a pearly papule with prominent vessels on his eyelid. He has it excised, and the lesion showed multiple nodules of basaloid cells with scant cytoplasm and peripheral palisading. The nodules appear separated from the stroma. His lesion (A) frequently metastasizes to distant sites (B) is correlated to sun exposure (C) is associated with HPV infection (D) may arise on mucosal surfaces

is correlated with sun exposure (basal cell carcinoma) (TOPNOTCH)Robbins Basic Pathology, 8th ed., p 852