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Flashcards in YFV Deck (10)
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1
Q

What viral family does YFV belong to?

A

Flavivirdae…like HCV and HGV

2
Q

What kind of genome does YFV have?

A

Non-segmented +ssRNA

5’cap

3
Q

What is the outermost layer of YFV?

A

E1 and E2 glycoproteins

4
Q

How is YFV spread?

A

Aedes mosquitos

5
Q

Is YFV cytolytic?

A

Yes…serious systemic disease

6
Q

What kind of immune response is caused by YFV infection?

A

Both humoral and cellular…resulting inflammation causes tissue destruction

7
Q

What are the symptoms to a YFV infection?

A

Severe systemic disease
Flu-like syndrome (GI hemorrhages –> black vomit)
Loss of liver, kidney, and/or heart function
Hemorrhagic fever
Shock
Death (50%)

8
Q

How is YFV diagnosed?

A
Immunoflorescence 
RT-PCR
ELISA
Various serologies
Direct isolation of the virus
9
Q

How is YFV treated?

A

Supportive care

Vector control measures

10
Q

What kind of vaccine is there for YFV?

A

Live-attenuated vaccine