ZOLEDRONIC ACID Flashcards Preview

patient MCQ > ZOLEDRONIC ACID > Flashcards

Flashcards in ZOLEDRONIC ACID Deck (10)
Loading flashcards...
1
Q

what is Zoledronic acid

A

a bisphosphonate

2
Q

how does it work?

A

adsorbed onto hydroxyapatite crystals in bone, slows the rate of growth and dissolution therefore reducing turnover

3
Q

dose if renal impairment?

A

avoid if <30ml/min

4
Q

who cannot receive zolendronic acid?

A
hepatic impairment 
atypical femoral fractures 
cardiac disease- fluid overload
patients on other medication affecting renal function 
dental disease
5
Q

what should be monitored?

A

correct calcium metabolism disturbance before starting
monitor serum electrolytes
monitor renal function in high risk patients

6
Q

can you give in pregnancy and BF

A

C/I in women of child bearing age

avoid in BF

7
Q

what must patients look out for?

A

hip, thigh or groin pain during treatment: atypical femoral fractures
osteonecrosis of the daw: dental mobility, pain, non healing sores, discharge

8
Q

risk factors for osteonecrosis?

A

potency, dose, duration, smoking, dental disease,

9
Q

3 safety concerns with this drug

A

atypical femoral fractures, osteonecrosis of 2) the jaw 3)the auditory canal

10
Q

risk factors for osteonecrosis of the ear canal

A

steroid use, chemotherapy, infection, ear operation, cotton bud use