Zollinger Ellison syndrome

Question 1

What is it

Answer 1

a rare endocrine disorder with 3 main parts:

- gastronoma (gastrin secreting tumour - increased gastrin causing peptic ulcers)

Question 2

what is gastrin?

Answer 2

released by G cells in the

Question 3

what does gastrin do?

Answer 3

stimulates the parietal cells to secrete hydrochloric acid and increases cell division on the epithelial layer

Question 4

what does Brunner glands secrete?

Answer 4

mucous filled of bicarbonate to neutralise the acid.

Question 5

what happens in Zollinger Ellison syndrome?

Answer 5

G cells get a mutation and divide uncontrollably in the stomach or duodenum into gastronomas - these can be benign or malignant.

The increase in gastrin causes and increase in parietal cells secreting hydrochloric acid which causes erosion and peptic ulcers.

Question 6

where do ulcers occur?

Answer 6

more likely in the duodenum.

Question 7

what are the symptoms?

Answer 7

epigastric pain
bloating
belching vomiting
gastric ulcer pain - during eating 
duodenal ulcer pain - decreases while eating 
Diarrhoea 
steatorrhoea

Question 8

what is diagnosis?

Answer 8

peptic ulcers duiring endoscopy
high levels of gastrin in the blood, especially high levels of gastrin after giving secretin - which is meant to inhibit gastrin release.

Question 9

Treatment?

Answer 9

Medication to reduce Acid

Surgery to remove tumour

Question 10

where do gastronomes occur?

Answer 10

Mostly seen in the pancreas but can occur in the duodenum or stomach