Zollinger-Ellison Syndrome and Cirrhosis Flashcards Preview

Gastroenterology > Zollinger-Ellison Syndrome and Cirrhosis > Flashcards

Flashcards in Zollinger-Ellison Syndrome and Cirrhosis Deck (9)
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1
Q

What is CEA?

A

Carcinoembryonic antigen. It is a cancer marker for colorectal cancer

2
Q

What is CA153, CA125 and CA199?

A

CA153 - breast cancer
CA125 - Ovarian cancer
CA199 - Pancreatic cancer, gall bladder cancer, bile duct cancer, and gastric cancer

3
Q

What is Zollinger-Ellison syndrome?

A

It is a condition where peptic ulcers are associated with gastrin-secreting tumours (gastrinoma). Gastrin stimulates the secretion of excessive gastric acid and this results in multiple ulcers in the duodenum and stomach.

4
Q

What are the signs and symptoms of Zollinger-Ellison syndrome?

A

Abdominal pain, dyspepsia, and chronic diarrhoea due to the inactivation of pancreatic enzymes (from the low pH). There may also be steatorrhoea.

5
Q

What tests are done to determine if someone has Zollinger-Ellison syndrome?

A

Fasting serum gastrin levels: >1000pg/mL is diagnostic.
IF fasting serum gastrin level is 100-1000pg/mL and ZES is suspected, do the next test:

Secretin stimulation test: There will be raised serum gastrin level (>200pg/mL)

6
Q

When to suspect Zollinger-Ellison Syndrome?

A

If there are:

  • Multiple peptic ulcers
  • Ulcers found distal to the duodenum
  • FHx of peptic ulcers
  • FHx of pituitary, parathyroid, islet cells (pancreatic) adenomas
7
Q

Which adenomas are associated with Zollinger-Ellison Syndrome?

A

Pituitary, Parathyroid and Pancreatic (Islet cells) adenomas

8
Q

What are the signs of hypoalbuminaemia?

A

Oedema and Leuconychia

9
Q

What is the life threatening condition that portal hypertension can lead to? Why will it be caused?

A

Oesophageal varices due to portosystemic shunting, Oesophageal varices which may haemorrhage.