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1
Q

Antidepressants used in patients with epilepsy(with/without HTN)

A

Paroxetine ( almost all SSRIs are safe in HTN)

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2
Q

Antidepressant that should be avoided in seizure

A

Bupropion

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3
Q

Antidepressant for patients who are obese

A

Bupropion/Venlafaxine

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4
Q

Drug of choice for epileptic patient who has loss of appetite

A

Mitrazapine

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5
Q

Antidepressants act on which area in the brain

A

Post-synaptic

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6
Q

Anxiolytic with least sedation and withdrawal symptoms

A

Bupropion

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7
Q

Antidepressant used with cardiac patients

A

Sertraline

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8
Q

Antidepressant, safe, in pregnancy

A

Sertraline

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9
Q

Antidepressants safe in breastfeeding

A

Sertraline, paroxetine

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10
Q

Secondary Tricyclic Antidepressants?

A

nortriptyline (is a metabolite of amitriptyline), protriptyline, and desipramine (is a metabolite of imipramine).

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11
Q

Tertiary TCAs?

A

amitriptyline, imipramine, clomipramine, trimipramine, and doxepin.

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12
Q

Nonselective MAO A-B Inhibitors

A

Phenelzine , Tranylcypromine , Isocratic

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13
Q

Selective MAO A inhibitors

A

Moclobemide

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14
Q

Selective MAO-B inhibitor

A

Rasgiline , Selegiline

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15
Q

Washout period when switching from MAOIs to other antidepressants

A

2 weeks

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16
Q

Drug used in case of sexual dysfunction developed after SSRIs

A

Bupropion

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17
Q

Anxiety treatment

A

1st line : SSRIs
2nd line : Buspirone , TCAs
Others : propranolol, BZDs

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18
Q

Typical Antipsychotics

A

Haloperidol , Chlorpromazine

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19
Q

S.E of typical antipsychotics

A

Extrapyramidal side effects
Worsen negative symptoms

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20
Q

Atypical Antipsychotics

A

Clozapine , Aripiprazole , Quetiapine , Olanzapine

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21
Q

Clozapine S.E

A

Cause agranulocytosis

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22
Q

DOC for patient with Tardive Dyskinesia

A

Valbenazin

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23
Q

Meds for Extrapyramidal S.E

A

Benztropine , Diphenhydramine , BZDs

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24
Q

Most effective in treating positive symptoms in schizophrenia

A

Atypical Antipsychotics ( 2nd generation )

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25
Q

Psychotic Patient taking olanzapine with high glucose. What is alternative?

A

Haloperidol ( less metabolic changes)

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26
Q

How does smoking affect clozapine and olanzapine

A

Increase metabolism, decrease medication concentration, increase clearance of medication

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27
Q

Acute mania treatment

A

Valproate or Lithium + Antipsychotic

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28
Q

Acute Bipolar treatment

A

Lithium or lamotrigine Also Lurasidone, Olanzapine / fluoxetine

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29
Q

Maintenance of mania

A

Lithium+/-2ndgenerationofAntipsychotic(SGA)

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30
Q

Maintenance of bipolar

A

Lamotrigine

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31
Q

Safe drugs for treatment of Bipolar disease in a pregnant woman

A

Lamotrigine , levetiracetam , lurasidone

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32
Q

Mood stabilizer?

A

Lithium

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33
Q

Side effects of lithium?

A

Tremor , GI , edema , hypothyroidism

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34
Q

Lithium effect on CrCl and BUN?

A

Decrease CrCl and increase BUN which cause renal impairment

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35
Q

Monitoring of lithium?

A

Monitor, renal and thyroid every 6 to 12 month

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36
Q

Treatment of convulsions due to lithium toxicity

A

Phenobarbital , propofol , BZDs

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37
Q

Lithium antidote?

A

Sodium polystyrene sulfonate NaHCO3

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38
Q

Why is carbidopa given with levodopa?

A

To prevent peripheral metabolism of levodopa

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39
Q

Mechanism of action of levodopa

A

Increase the dopamine level in brain leading to stimulate dopamine receptor

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40
Q

Dopamine receptor agonist ( in treatment of parkinson’s disease)

A

Pramipexole, Ropinirole, Apomorphine, Rotigotine

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41
Q

Amantadine uses?

A

Antiviral , Antiparkinsonian , Dopamine agonist
#cause Livedo reticularis ( شبكة تجلطات في القدمين )

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42
Q

Which anticholinergic is used in treatment of PD

A

Trihexyphenidyl

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43
Q

Treatment of nausea and vomiting in parkinson’s disease patients

A

Domperidone

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44
Q

Treatment of Psychosis in Parkinson’s disease patients

A

Quetiapine , primavanserin

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45
Q

Mild-moderate Alzheimer disease treatment

A

Donepezil , Rivastigmine , Glutamine

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46
Q

Advanced Alzheimer disease treatment

A

Donepezil

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47
Q

Dementia + Alzheimer disease treatment

A

Rivastigmine

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48
Q

BZDs used in Alzheimer ?

A

DACL
Diazepam
Alprazolam
Clonazepam
Lorazepam

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49
Q

Alzheimer patient with urinary urgency treatment

A

Oxybutynin

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50
Q

Moderate-severe Alzheimer treatment

A

Memantine +/- Donepezil

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51
Q

Anti-epileptic, safe in pregnancy

A

Levetiracetam , Lamotrigine

52
Q

Anti-epileptic safe in breast-feeding

A

Levetiracetam

53
Q

Which anti-epileptic require renal adjustment

A

Topiramate

54
Q

Anti-epileptic used in absence seizures

A

Ethosuximide

55
Q

Anti-epileptics used for elderly patients

A

Alprazolam , Oxazepam , Trizolam

56
Q

Treatment of neuropathic, pain and depression

A

1st : Duloxetine , Pregabaline
Others ; Gabapentin , venlafaxine , BZDs

57
Q

Side effects of Phenytoin

A

Gingival hyperplasia, nystagmus, hirsutism, acne, purple glove syndrome

58
Q

ADHD Treatment

A

Atomixifin

59
Q

Which vaccine cause autism

A

Thimerosal ( mercury) containing vaccines

60
Q

Which all drugs dilate cervix

A

Oxytocin , Dinoprostone , Misoprostol

61
Q

Safe HIV med for pregnancy/during labor

A

Zidovudine

62
Q

Which drug stop premature labor?

A

Ritodrine

63
Q

Treatment of preterm labor?

A

Magnesium sulfate , Indomethacin, Nifedipine

64
Q

Treatment of Eclampsia

A

Mg sulfate

65
Q

Drugs that induce abortion

A

Misoprostol, Mifepristone, Methotrexate

66
Q

Which anti-estrogen causes abortion?

A

Anastrazole

67
Q

Anti-progesterone causes abortion

A

Mifepristone, Misoprostol

68
Q

Prevention and treatment of postpartum and post abortion hemorrhage?

A

Ergonovine

69
Q

A Healthy mid age woman wants contraceptive which drug to give?

A

Ethinyl estradiol/ inestrenol (combination)

70
Q

In which cases Ethinyl estradiol/ inestrenol (combination) is not given and what is the alternative contraceptive

A

35 + smoker or migraine headache or obese
• > 50
• Breastfeeding
• DM + Vascular disease
• Risk of DVT or history of
• Hx of uncontrolled HTN or heart problems
• Breast or endometrial cancer
• Need to get pregnant
Alternative is levonoregestrol

71
Q

Which hormone the oral contraceptives suppress?

A

GnRH ( gonadotropine releasing hormone)

72
Q

Oral contraceptives work on which phase of the cycle?

A

The ovulation phase

73
Q

When taking Hydroxyurea contraceptive is required during and after how long? (Male and female)

A

Male 12 months
Female 6 months

74
Q

Treatment of infertility in women who don’t ovulate?

A

Clomiphene citrate

75
Q

Which hormone is predominant is the ovulation phase?

A

Luteinizing hormone

76
Q

Which drug inhibits estrogen synthesis

A

Tamoxifen

77
Q

Human chorionic gonadotropin is used for what?

A

Induce ovulation and treat infertility

78
Q

Treatment of facial flushing and dry
Vagina

A

Estrogen

79
Q

Isotretinon should be stopped before pregnancy by how long?

A

1 month

80
Q

which drugs should be stopped before pregnancy by 2 months?

A

Neostigmine and Fingolimod

81
Q

Ribavirin should be stopped before pregnancy by how long?

A

6 months

82
Q

Leflunomide should be stopped before pregnancy by how long?

A

2 years

83
Q

Mycophenolate should be stopped before pregnancy by how long ( answer for male and female)

A

Male 12 weeks
Female 6 weeks

84
Q

Why is Ciprofloxacin contraindicated in pregnancy

A

Causes anemia of fetus if taken in the first semester

85
Q

Why is nicotine and beta blockers contraindicated in pregnancy

A

Decrease blood flow to uterine

86
Q

Why are ACE-Is are contraindicated in pregnancy

A

Effect fetal growth

87
Q

Why is warfarin contraindicated in pregnancy?

A

Causes nasal bone, hypoplasia in neonate

88
Q

Which drug/hormone causes genital malformations in infants if taken during pregnancy?

A

If the question ask about hormone answer is androgen
If they ask about drug answer is Finasteride

89
Q

Why is Progesterone contraindicated during pregnancy

A

Causes fetal, productive abnormalities

90
Q

Which anti-estrogen used in breast cancer 

A

Tamoxifen

91
Q

Treatment of breast cancer

A

Raloxifen and Tamoxifen

92
Q

Prophylaxis of breast cancer

A

Raloxifen

93
Q

What are the early symptoms of breast cancer?

A

Dimples or nipple discharge

94
Q

Which drug is safe to treat UTI during pregnancy

A

Nitrofurantoin

95
Q

Pregnant with UTI+G6PD

A

Cefuroxime

96
Q

Prevention of recurrence of UTI?

A

Trimethoprim-sulfamethoxazole (TMP/SMX)

97
Q

Pregnant woman with vaginal itching and E.coli

A

Nirtofurantoin

98
Q

Pregnant woman with pyelonephritis she’s been treated with IV ceftriaxone what is the most appropriate antibiotics

A

Amoxicillin/Clavulanate or Cefuroxime

99
Q

Pregnant with Syphilis

A

Benzathine penicillin, Amox/Clavul
If she has allergy to Penicillin
Erythromycin , ceftriaxone

100
Q

Breastfeeding with mastitis

A

Dicloxacillin , Cephalexin Amox/Clavul
If there’s penicillin allergy then
Clarithromycin

101
Q

Pregnant with candida albicans

A

Clotrimazole

102
Q

Anti-fungals contraindicated in pregnancy

A

Griseofulvin , Ketoconazole , Voriconazole

103
Q

Anti-fungals safe in pregnancy

A

Amphotericin B , Topical imidazole , Nystatin

104
Q

Antifungals contraindicated in lactation

A

Ketoconazole , Itraconazole , Voriconazole

105
Q

Antifungal, safe in lactation

A

Fluconazole

106
Q

Pregnant with tonic clonic seizure

A

Valproic acid + folic acid

107
Q

Pregnant with schizophrenia

A

Olanzapine , Risperidone , Quetiapine

108
Q

Laxatives contraindicated in pregnancy

A

Senna and castor oil

109
Q

Treatment of constipation in pregnancy

A

Psyllium , glycerin suppositories or lactulose

110
Q

Nausea with or without vomiting in pregnancy

A

Vit B6 +/- Doxylamine

111
Q

Gastroesophageal reflux treatment in pregnancy

A

Calcium carbonate antacid

112
Q

Which anticoagulants are safe to use in pregnancy

A

Low molecular weight heparin

113
Q

Treatment of asthma in pregnancy

A

Albuterol, Cromolyn

114
Q

Treatment of glaucoma in pregnancy

A

Brimonidine or timolol

115
Q

Treatment of hyperthyroidism in pregnancy

A

1st PTU (Propylthiouracil)
2nd methimazole

116
Q

Pregnant with Diabetes

A

1st insulin
2nd metformin, Glyburide

117
Q

Pregnant with hypertension

A

Methyldopa Labetolol Nifedipine

118
Q

DOC for emergency and urgency hypertension in pregnancy

A

Hydralazine

119
Q

Which bacteria is responsible for milk, production in women

A

Lactobacillus

120
Q

1st baby milk is called?

A

Colostrum

121
Q

Which medications increase prolactin levels

A

Metoclopramide Methyldopa , Estradiol
Serotonin, GABA, Opioids

122
Q

Which medication decreased prolactin levels

A

Bromocriptine , Cabergoline

123
Q

Which immunoglobulin crosses placenta

A

IgG

124
Q

Which is the largest immunoglobulin

A

IgM

125
Q

Which is the immunoglobulin found in anaphylaxis, asthma, allergy, and hypersensitivity

A

IgE

126
Q

Which immunoglobulin found in infection disease

A

IgM

Pharma (4 decks)

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