0120 - Cardiac 2/3 Flashcards
Right to left shunts?
Truncus arteriosus, Transposition, Tricuspid atresia, Tetralogy of Fallot, Total anomalous pulmonary venous return (TAPVR)
Tetralogy of Fallot
Abnormal anterior and cephalic displacement of infundibular portion of inter ventricular septum: VSD, pulmonic stenosis, overriding aorta (receiving blood flow from both ventricles), and RV hypertrophy. “Tet” spells following exertion b/c systemic VASOdilation -> increased right to left shunt. Associated with diGeorge.
Transposition of great vessels
Aorta is ANT and leaves RV while pulmonary artery is POSTerior and leaves LV. Requires shunt to support life. Failure of aorticopulmonary septum to spiral. Most common cause of cyanosis in NEONATE period. Associated with diabetic mother.
VSD
Left to right shunt. Asymptomatic at birth. Most self resolve but large lesion -> LV overload and HF
ASD
Wide, fixed split S2 (2/2 constant P2 late). Usu. septum secundum. NOT patent foramen ovale b/c septa are missing not unfused.
Patent ductus arteriosus
Indomethicin closes, PGE2 keeps open. Machine-like continuous murmur.
Eisenmenger syndrome
An uncorrected Left-to-right shunt can cause pulmonary vasculature to be remodeled and increased resistance eventually leading to a REVERSAL to a R-L shunt -> cyanosis (clubbing, and polycythemia)
TAPVR
Total anomalous pulmonary venous return. Pulmonary veins drain into Right heart circulation. Associated with ASD +/- PDA.
Coarctation of the aorta
Infantile type is PRE-ductal (before ductus arteriosus) and is associated with XO Turner’s. PGE2 to prevent closure. Adult type is post-ductal (after ligamentem arteriosum), associated with rib notching (collateral circulation), HTN of UPPER limbs and weak pulses in lower extremities
Truncus arteriosus
No septation. Often associated with a VSD. Seen in diGeorge
Congenital rubella is associated with what cardiac defects?
Septal, PDA, pulmonary artery stenosis
Turner syndrom is associated with what cardiac defects?
Bicuspid valve, coarctation of the aorta
Monckeberg arteriosclerosis
Medial calcific sclerosis. Calcification of then media NOT intima of blood vessels. Usu. benign. X-rays of radial or ulnar arteries.
What type of people would you expect to get an abdominal aortic aneurysm vs. a thoracic aortic aneurysm?
Abdominal - 50’s smoker. Thoracic - Marfan syndrome, tertiary syphilis. Associated with cystic medial degeneration in the older population
Aortic dissection Sanford type A vs. B?
A involves ascending aorta (+/- descending) while B does not.
Prinzmetal angina
2/2 to coronary spasm. Triggers include tobacco, cocaine, triptans. Tx = CCB, nitrates, smoking sessation
MI days 3-14: what do I need to know?
Macrophages doing their thing. Granulation tissue. Hyperemic border with central yellow-brown softening on gross. Free wall rupture, papillary muscle rupture, IV septal rupture (macrophage-mediated structural degradation). LV pseudoaneurysm = mural thrombus plugs hole = a time bomb
How long after occlusion does it take for histological or gross changes to occur in a MI?
FOUR hours. Coincedentally (or not), it takes four hours for troponin I to start rising (most specific cardiac marker)
Why use CK-MB?
Found in myocardium and skeletal muscle (less specific). BUT, it goes back to normal after 48 hours (troponins rise for 7-10 days). Therefore , it’s used for diagnosing re-infarction
Anteroseptal vs. Anterolateral leads?
V1-V2 vs. V4-V6
Dressler syndrome
autoimmune, takes several weeks to months (true ventricular aneurysm timeline)
Etios of dilated cardiomyopathy
Alcohol, wet Beriberi, Coxsackie B myocarditis, chronic Cocaine, Chagas, Doxorubicin toxicitiy, hemochromatosis, peripartum cardiomyopathy. Idiopathic and congenital.
Hypertrophic cardiomyopathy
LV ONLY. Most are familial and AD (Beta-myosin heavy chain mutation) although rarely associated with Fridreich ataxia. Can syncopize if septum to close to mitralm leaflet. Diastolic dysfunction. S4. Myofibrillar disarray and fibrosis. Tx = Cessation of high-intesnsity, Beta-block or non-di CCB.
Explain night symptoms of HF?
Orthopnea and PND are due to increased venous return 2/2 to the gradual reabsorption of pooled blood toward the lungs.
Physical signs of bacterial endocarditis
Fever, new murmur, Roth spots, Osler nodes, Janeway lesions, splinter hemorrhages on nail bed
Acute vs. subacute etios of endocarditis?
Acute - Staph aureus. Subacute - Viridians strep.
Culture negative bacterial endocarditis?
Coxiella burnetii, Bartonella. Or 2/2 malignancy, hpercoagulable state, lupus
Rheumatic fever histo findings
Aschoff bodies (granuloma with giant cells), Anitschkow cells (enlarged macrophages w/ ovoid nucleus).
Fibrinous vs. serous pericarditis?
Fibrinous is usu. Dressler, uremia, radiation. Serous is usually viral or inflammatory/auto-immune
Findings in cardiac tamponade
Beck’s triad (hypotension, distended neck veins, distant hear sounds). Tachy. Pulsus paradoxes, Kussmaul sign (rise of JVP on inspiration), ECG electrical alternans