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Immunology & Serology > 02 History > Flashcards

02 History Flashcards

(79 cards)

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1
Q

Historian that documented variolation

A

Voltaire

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2
Q

Smallpox vaccination

A

Edward Jenner

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3
Q

Cross immunity

A

Edward Jenner

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4
Q

Virus responsible for smallpox

A

Variola

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5
Q

Virus responsible for cowpox

A

Vaccinia

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6
Q

Virus responsible for chickenpox

A

Varicella

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7
Q

Discovered phagocytosis

A

(Ernst) Haeckel

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8
Q

Father of Immunology

A

Louis Pasteur

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9
Q

Pioneer of attenuation

A

Louis Pasteur

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10
Q

Chicken cholera vaccination

A

Louis Pasteur

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11
Q

Anthrax vaccination

A

Louis Pasteur

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12
Q

Rabies vaccination

A

Louis Pasteur

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13
Q

Source of rabies vaccine

A

Dried spinal cord of rabid dog

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14
Q

Methods of attenuation

A

Heat, Aging, Addition of Chemicals

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15
Q

Champion of cellular immunity

A

Elie Metchnikoff

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16
Q

Nobel Laureate for observing phagocytosis

A

Elie Metchnikoff

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17
Q

Metchnikoff’s test animal for phagocytosis discovery

A

Transparent starfish larvae

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18
Q

Champions of humoral immunity

A

Emil Von Behring & Kitasato Shibasaburo

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19
Q

Nobel laureate for deriving diphtheria and tetanus antitoxin

A

Emil Von Behring

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20
Q

C. tetani toxin

A

Tetanospasmin

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21
Q

Passive immunization

A

Emil Von Behring & Kitasato Shibasaburo

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22
Q

Demostrated cutaneous / type 4 hypersensitivity

A

Robert Koch

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23
Q

Discovered agglutination reactions

A

(Herbert Edward) Durham & (Max) Von Gruber

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24
Q

First serologic test for S. typhi

A

Widal Test

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25
Derived the first serologic test for typhoid fever diagnosis
Ferdinand Widal
26
Antibody formation theory
Paul Ehrlich
27
Discovered ABO blood groups
Karl Landsteiner
28
Book written by Karl Landsteiner
The Specificity of Serologic Reactions
29
Discovered anaphylaxis & immediate hypersensitivity
(Paul) Portier & Charles Richet
30
Nobel prize winner for anaphylaxis
Charles Richet
31
Most sever and life-threatening form of hypersensitivity
Anaphylaxis
32
Discovered opsonins
Almoth Wright, Stephen Douglas, & Joseph Denys
33
Substances that coat pathogens in order to make them more susceptible to phagocytosis
Opsonins
34
Described the relationship between immunity and hypersensitivity
(Clemens) Von Pirquet & (Bela) Schick
35
First tuberculosis vaccine from M. bovis
Albert Calmette & Camille Guerin
36
Complement-mediated cytolysis
(Richard) Pfeiffer & (Hans) Buchner
37
Principal soluble mediators of inflammation
Complement
38
Nobel laureate for the discovery of complement proteins
Jules Bordet
39
Developed the hemolytic plaque assay
Niel Jerne
40
Concept of immunological tolerance
Peter Medawar
41
Genes that control the synthesis of HLAs
Major Histocompatibility Complex
42
Discovered murine MHCs
George Snell
43
Discovered human MHCs
Jean Dausset & Baruj Bennaceraf
44
Deciphered the polypeptide structure of antibody molecules
Rodney Porter
45
Radioimmunoassay of peptide hormones
Rosalyn Yalow
46
Described the action of lysozymes
Alexander Fleming
47
Discovered penicillin
Alexander Fleming
48
Enzymes inside lysosomes that can kill Gram positive microorganisms by destroying their cell wayy
lysozyme
49
Discovered that adaptive immunity is mediated by lymphocytes
James Gowan
50
Developed the technique to produce monoclonal antibodies
Cesar Milstein & Georges Kohler
51
Technique used in producing monoclonal antibodies
Hybridoma technology
52
Made crucial discoveries about the structure of immunoglobulins, as well as the first complete sequence
Gerald Edelman
53
Developed the quantitative precipitin assay
Michail Heidelberger
54
Heidelberger's collaborator in quantitative precipitin assay studies on antigen-antibody reactions
Kendall
55
Chinese method of inhaling pulverized smallpox crusts for immunization
Variolation
56
Discovered antibody diversity and T cell receptor diversity
Tonegawa Susumu
57
Discovered intereferons
Alic Isaacs & Jean Lindemann
58
Substances containing antiviral properties by blocking the translation of viral proteins
Interferon
59
Original name of HIV
Lymphadenopathy Associated Virus (LAV)
60
Isolated a retrovirus from an immunocompetent homosexual man with lymphsdenopathy
Luc Montaigner
61
Renamed LAV into HAV
Robert Gallo
62
Introduced the concepts of organ transplantation
E. Dounal Thomas & Joseph Murray
63
Principle of double recognition
Peter Doherty & Rolf Zinkernagel
64
Gene that regulates T cell development
FOX3p gene
65
Discovered human papilloma virus (HPV)
Warts
66
Discoveries concerning innate immunity
Bruce Beutler & Jules Hoffmann
67
Discovered the dendritic cell and its role in adaptive immunity
Ralph Steinman
68
Discovered antibody diversity and T cell receptor diversity
Tonegawa Susumu
69
Discovered intereferons
Alic Isaacs & Jean Lindemann
70
Substances containing antiviral properties by blocking the translation of viral proteins
Interferon
71
Original name of HIV
Lymphadenopathy Associated Virus (LAV)
72
Isolated a retrovirus from an immunocompetent homosexual man with lymphsdenopathy
Luc Montaigner
73
Renamed LAV into HAV
Robert Gallo
74
Introduced the concepts of organ transplantation
E. Dounal Thomas & Joseph Murray
75
Principle of double recognition
Peter Doherty & Rolf Zinkernagel
76
Gene that regulates T cell development
FOX3p gene
77
Discovered human papilloma virus (HPV)
Warts
78
Discoveries concerning innate immunity
Bruce Beutler & Jules Hoffmann
79
Discovered the dendritic cell and its role in adaptive immunity
Ralph Steinman

Immunology & Serology (2 decks)

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