[07] Semaglutide Flashcards
(19 cards)
What are the brand names for Semaglutide?
- Ozempic
- Wegovy
- Rybelsus
Who developed Semaglutide?
Novo Nordisk
When was Semaglutide developed?
2012
What is the primary use of Semaglutide?
- Type 2 diabetes
- Long-term weight management
How is Semaglutide administered?
- Subcutaneous injection
- Orally
What was Semaglutide’s rank in most prescribed medications in the U.S. in 2020?
129th
How many prescriptions of Semaglutide were made in the U.S. in 2020?
Over 4 million
For which condition is Semaglutide primarily indicated?
Type 2 diabetes
For what other condition is higher-dose Semaglutide indicated?
Long-term weight management
Who is eligible for Semaglutide weight management therapy?
- BMI ≥ 30 kg/m^2
- BMI ≥ 27 kg/m^2 with at least one weight-related comorbidity
What kind of receptor agonist is Semaglutide?
GLP-1 receptor agonist
GLP-1 - Initials
Glucagon-like Peptide-1
How does Semaglutide affect insulin?
Increases production
What other hormone does Semaglutide inhibit?
Glucagon
What effect does Semaglutide have on appetite and digestion?
- Reduces food intake
- Lowers appetite
- Slows down digestion
What is unique about Semaglutide’s chemical structure compared to human GLP-1?
- Missing first six amino acids of GLP-1
- Substitutions at GLP positions 8 and 34
What enzyme does Semaglutide resist breakdown by?
Dipeptidyl peptidase-4
What is the half-life of Semaglutide in the blood?
165-184 hours
What are the common side effects of Semaglutide?
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Constipation
