1

Question 1

Which type of microneedles don’t have to be removed after application

Answer 1

Dissolving microneedles

Question 2

What type of vaccine can benefit from delivery system

Answer 2

Subunit vaccine

Question 3

Which nanoparticles type/s is/are made of amphiphilic molecules

Answer 3

Liposomes

Question 4

Nanoparticle made of a polymer with many branches

Answer 4

Dendrimers

Question 5

What’s the size of a dendrimers

Answer 5

1.5-10nm

Question 6

Microsphere, Microparticles

Answer 6

•can be solid microparticales
Porous microspheres
Hollow in nature microcapsules
•spherical
•made from lipids , polymers , protiens etc
•size 1 - 1000 micro
• PLA /PLGA mostly in market

Question 7

What’s the mechanism controlling drug release of incorporated drug in Microspheres

Answer 7

Degradation rate of matrix in vivo

Question 8

Which type of contruct have an EPR effect

Answer 8

•polymer-drug conjugates: dendrimers
•protein nanoparticles
•polymeric nanoparticles
Micro capsules (no)

Question 9

Stealth nanoparticles

Answer 9

•solid polymeric nanoparticles coated with PEG on surface
•Hydrophilic surface
•less recognized by immune system
•prolonged half life
•Inc plasmas circulation time ,
Inc accumulation at leaky site
•less accumulated in liver and spleen
•achieve active targeting by attaching targeting groups on nanoparticles

Question 10

Quality control dissolution test

Answer 10

•Used to Verify safety and efficacy
•over discrimantory methods are sometimes chosen
•surfactants are not always added:
-in reciprocating cylinder USP apparatus 3 : can’t be added
-in sink condition, added in conc above the CMC “Critical micelle conc”
•sink conditions are generally used
•they are simpler than predictive test
•they do not simulate closely the physiological conditions in the stomach and intestines,

Question 11

Abraxane, albumin-based nano particles formulation containing paclitaxel/taxol

Answer 11

•Inc the overall solubility of the system
Low solubility
•PREVIOUS FORMULATION: solvent (cremophor) a highly toxic castor oil derivative
Abraxane: avoids the toxicity when used with taxol
•abraxane used for treatment of breast cancer
•it accumulates in cancer tissue by active and passive targeting

Question 12

PEGylated protiens advantages and disadvantages

Answer 12

Advantages:
•improve drug delivery ( prolonged half life and less enzymatic degradation)
•low toxicity
•high hydration higher solubility
•ease of use of conjugation with drugs
Disadvantages:
•when it’s conjugated with protien therapeutics, activity can be reduced

Question 13

Subcutaneous and intramuscular administration of liposomes can?

Answer 13

Target drug to reach lymphatic system, lymph nodes (B, T and other immune cells)

Question 14

Ambisome , liposomal formulation of Amphotericin B

Answer 14

•given IV
•in bilayer of liposomes
• they are SUV “small unilamellar vesicles” 80nm
•poorly soluble
•enable to reduce high risk of nephrotoxicity ,associated with Amphotericin B (when not formulated to liposomes)

Question 15

Sustained release liposomes

Answer 15

•MVV(100nm to several micrometers)
“multi vesicles liposomes”
•epidural administration
•multiple bilayers
•slow breakdown and slow clearance controlling the drug release
•form a depot in site of injection

Question 16

To reduce drug opsonisation?

Answer 16

Fatty acid chains within the phospholipidd:
Inc the degree of saturation (single bond) and the length
Long and without double bonds

Question 17

To improve drug retention within the liposomes

Answer 17

REDUCE DRUG OPSONISATION

Fatty acid chains within the phospholipidd:
Inc the degree of saturation (single bond) and the length
Long and without double bonds

Question 18

Which type of microneedles are used in liquid vaccine formulation

Answer 18

Hollow microneedle

Question 19

What is a nanoparticle that have star-shape

Answer 19

Dendrimers

Question 20

Which apparatus CANNOT be used with surfactant in medium

Answer 20

3