3 Flashcards
Polymeric Micelle
•they have narrow size distribution
•made of copolymers with surfactant characteristics
•very low cmc, prevent rapid dissociation ,don’t break down easily
Antibody therapy
•they’re both targeting group and a drug
•Used to target cancer cells
•the fragments are more effective and cheaper than the whole body
•monoclonal antibodies are generally used
•
Subunit vaccine
•it doesn’t contain the whole microorganism
•can benefit from a delivery system
If a liquid protien formulation prepared at 3.5 ph there is a risk of
Denaturation
Biopharmaceuticals
•derived from biological source.
•unstable after administration & on storage
•high molecular wt drugs
•eg, heparin, Nucleic acids, carps, vaccines, protien and peptide.
Which host could make the production of recombinant protiens cheaper
Plant
Why cyclosporin have resistance to pepsin
It’s cyclic& lipophilic
Which media contains lipolysis products
FeSSIF
Formulation of liposomes requirments
Correct temperature
Correct lipid/water ratio
Added energy to the system
How can polymer drug conjugation reduce aggregation of protein drugs
Hydrophilic polymer reducing hydrophobic protien protien interaction
Nanocryctals
•amphorous and,or crystalline shape
•surfactants are added in formulation during size reduction to improve stability
•in oral its formulated into tablets and capsules
•in case of tablets ,high nanocryctal drug loading should be avoided
Which are the most difficult drugs to incorporate inside liposomes
Intermediate log p drugs;
Log p between 1.7 and 5
How can Nucleic acid drugs/generally protien drugs loaded be incorporated into liposomes
Adsorped on the surface of cationic liposomes
Which apparatus is suitable for testing poorly soluble drugs
4
Which liposomes have the largest capacity to incorporate Hydrophilic drugs
LUV
