1/2 Ch. 24-25 Flashcards
(28 cards)
Function is to make prostaglandins.
Cyclooxygenase (COX) enzyme
Protects stomach and regulates platelets.
COX-1
Triggers inflammation and pain.
COX-2
Drugs that are also called nonsteroidal anti-inflammatory drugs (NSAIDs) and non-opiod analgesics
COX enzyme inhibitors
Chemical name: acetylsalicylic acid.
NSAID: aspirin
What amount of aspirin has a beneficial effect and protects against MI?
81 mg
What amount of aspirin is administered for pain?
325 mg (high dose)
What are the therapeutic uses of aspirin?
- Suppresses inflammation
- Pain reflief
- Suppress platelet aggregation
- Protective dose (81mg)
Why should aspirin be taken with food?
NSAIDs are harsh on the stomach lining. This increases the risk for ulcer development, internal bleeding, N/V
Why shouldn’t people with AKI/CKI take aspirin?
Aspirin will cause further damage to the kidneys in people with AKI/CKI.
What is salicylism?
Tinnitus. Adverse reaction to aspirin
What is Reye’ syndrome and what causes it?
Sudden brain/liver damage in pediatric patients. Caused by aspirin.
- 50/50 survival rate
- Pregnancy category X
Which blood thinner interacts with aspirin and causes bleeding.
Warfarin
- Aspirin increases warfarin absorption (additive effect)
Why shouldn’t a patient take aspirin and drink alcohol?
Both aspirin and alcohol irritate the stomach lining causing ulcers and increasing the risk for gastric bleeding.
What formulations is aspirin available in?
- Plain
- Eneric coated
- Time released
- Rectal
How should aspirin be administered?
- With food to minimize GI irritation
- Dosage is age- and condition- dependent
What nursing interventions should be followed when caring for a patient takin aspirin? 3 things
- Monitor for bleeding
- Instruct the patient to take aspirin with food
- Stop one week before invasive procedure/ surgery
(dental word)
Which drug is used for short-term pain management (less than 5 days)
NSAID: Ketorolac
How is Ketorolac administered?
PO, IM, IV, Intranasal
Why shouldn’t Ketorolac be used for more than 5 days?
Increases risk of kidney failure.
What do all Ibuprofen NSAIDs do?
All have anti-inflammatory, analgesic, and antipyretic properties
What could all ibuprofen NSAIDs cause?
Gastric ulceration, bleeding, and renal impairment
Ibuprofen does not protect against?
MI, TIA, CVA
What is the main difference between aspirin and ibuprofen?
Ibuprofen does not thin blood
- Risk for bleeding out is low
- If taken without food continuously, bleeding will occur.
