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1

superantigen exotoxins are secreted by

1. streptococcus pyogenes
2. staphylococcus aureus

2

superantigens function by

cross linking the alpha chain of MHC2 on the APC with the variable region of the B-chain of T cell receptors on CD4 Th cells.

This creates polyclonal T cell activation, leading to increased I-2 and IFN-y.

The resulting release activates m0 and promotes the release of proinflammatory cytokines like IL-1, IL-6, TNFa

3

Staphylococcus arues superantigen exotoxins

1. TSST--Toxic shock syndrome is responsible for TSS
2. enterotoxin is food poisoning

4

Streptococcus pyogenes

1. SpeA is TSLC (toxic shock like syndrome) and the rash in scarlet fever
2. SpeB is necrotizing fascitis
3. SpeA,B,C are scarlet fever

5

lab values in rickets

1. decreased 25(OH) vitamin d
2. decreased ca
3. decreased phosphate
4. increased alkaline phosphatase
5. increased PTH

6

treat nocardia

bactrim

7

legionnaire's disease treatment

macrolides and respiratory tract: fluoroquinolones