Flashcards in 1 Deck (7)
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1
superantigen exotoxins are secreted by
1. streptococcus pyogenes
2. staphylococcus aureus
2
superantigens function by
cross linking the alpha chain of MHC2 on the APC with the variable region of the B-chain of T cell receptors on CD4 Th cells.
This creates polyclonal T cell activation, leading to increased I-2 and IFN-y.
The resulting release activates m0 and promotes the release of proinflammatory cytokines like IL-1, IL-6, TNFa
3
Staphylococcus arues superantigen exotoxins
1. TSST--Toxic shock syndrome is responsible for TSS
2. enterotoxin is food poisoning
4
Streptococcus pyogenes
1. SpeA is TSLC (toxic shock like syndrome) and the rash in scarlet fever
2. SpeB is necrotizing fascitis
3. SpeA,B,C are scarlet fever
5
lab values in rickets
1. decreased 25(OH) vitamin d
2. decreased ca
3. decreased phosphate
4. increased alkaline phosphatase
5. increased PTH
6
treat nocardia
bactrim
7
