1 - Intro to ANS

Question 1

Exogenous cholinergic molecules

Answer 1

Muscarine

Nicotine

Question 2

Parasymp (superior) pathway

Answer 2

Preganglionic –> Ach (N)

PostGanglionic –> Ach (M)

Target = Heart and vessels

Question 3

Types of Post ganglionic Sy

(Catergories and the receptors that they target)

Answer 3

Adrenergic –> B/a Receptors

Cholinergic –> either β2 or α1 receptors

PostG Sy Dopaminergic –> D1 receptorss

Question 4

Post synaptic receptors that act through IP3 –> Ca++ pathway

Answer 4

M1,3,5

Question 5

Muscarinic receptors that is on both pre and post synaptic side

Answer 5

M4

Question 6

Presynaptic muscarinic receptor

Answer 6

M2

Question 7

____ and ____ act within the acetylcholine within the synaptic cleft

Answer 7

AchE / BuChE

Question 8

_____ and ____ directly activate the SANS by releasing _______

Answer 8

Methylphenidate, Amphetamine

release NE

Question 9

Enzyme that converts NE to EPI

Answer 9

Phenylethanolamine-N-methyltransferase

Question 10

Mimic acetylcholine =

Answer 10

Cholinergic = muscarinic agnoists = Parasympathomimetic

Question 11

Block Ach =

Answer 11

Anticholinergic = muscarinic antagonist = Parasympatholytic

Question 12

Mimic NE =

Answer 12

Adrenergic = Adrenergic agnonist = Sympathomimetic

Question 13

Block NE =

Answer 13

Antiadrenergic = adrenergic antagonist = sympatholytic

Question 14

Cholinergic receptors are either (a)) ______ or (b) _______

Where are (a)?

Answer 14

a = nicotinic

b = muscarinic

Nicotinic can be in:

• Ganglionic
• Skeletal muscle
• Neuronal CNS

Question 15

Nicotinic receptos are ____ made out of __ subunits

Answer 15

ion channels

5

Question 16

Structures of the 2 neuronal nicotinic receptors

Answer 16

1. 3 β2’s and 2 α4’s
2. 5 α7’s

Question 17

Muscle nicotinic recepor subunits

Answer 17

α1, α1, β1, delta. gamma

Question 18

Muscarinic receptors are either ___ or ___

Answer 18

Gq coupled or Gi coupled

Question 19

Gq coupled muscarinic receptors

Answer 19

M1 = CNS

M3 = Ubiquitous

M5 = Cerebral BV

Question 20

Gi coupled muscarinic receptors

Answer 20

M2 = Heart + bladder, HIppocampus + Cereb. Cort.

M4 = Striatum

Question 21

Types of adrenergic receptors

Answer 21

α1, α2, β

Question 22

What are the Gq coupled adrenergic receptors

Answer 22

α1A

α1B

α1D

Question 23

What are the Gi coupled adrenergic receptors

Answer 23

α2 A/B/C

Question 24

Gs coupled adrenergic receptors

Answer 24

β1,2,3

Question 25

Where do you find Gi coupled adrenergic receptors?

Answer 25

GI, Panceas, CNS

Question 26

Receptor of the dilator (radial) muscle in the eye?

Answer 26

α1

Question 27

Receptor in ciliary muscle and sphincter pupillae

Answer 27

M3

Question 28

Receptor on the ciliary epithelium

Answer 28

β2 increases secretion of aq. humor

Question 29

Psy stimulation in the eye causes

Answer 29

constriction (circuar muscle)

Question 30

Sy stimulation of the eye causes

Answer 30

Dilation (radial muscles)

Question 31

Pressure equals =

Answer 31

flow (Q) x resistance (R)

Question 32

Flow (Q) equals =

Answer 32

SV x HR

Question 33

\_\_\_\_\_\_ relaxes skeletal muscles

Answer 33

B2

Question 34

\_\_\_ causes vasoconstrction

Answer 34

a1 and a2

Question 35

\_\_\_ causes vasodilation

Answer 35

B2

Question 36

Effect of M3 in vessels?

Answer 36

Vasoconstrict (M3 receptor = Gq coupled receptor that increases Ca++)

Question 37

M3 also causes relaxation via what mechanism?

Answer 37

NO * Phosphorylation of eNOS mediates* **L-Arg --\> NO** * NO causes guanylate cyclase to mediate:* ***GTP --\> cGMP***

Question 38

M3R vasoconstriction in pathologies wherein...

Answer 38

the vascular endothelium is disrupted (e.g. atherosclerosis)

Question 39

ANS receptors in the heart

Answer 39

M2 and B1

Question 40

ANS receptors in the cardiomyocytes act via what pathway (molecule)

Answer 40

Protein Kinase A

Question 41

In the lungs, ___ are present on the glands \_\_\_ are presenrt in smooth muscle

Answer 41

M3 on glands B2 and M3 on sm. muscle

Question 42

Apocrine glands function and receptors

Answer 42

Stress induced sweating (axilla, pubic region) a1 receptors

Question 43

Eccrine sweat glands function and receptor

Answer 43

Thermoreg M3 receptors

Question 44

GIT: Sympathetic 1. Increases secretion of salivary glands 2. Relaxes sm. muscle 3. Contracts sm. muscle 4. Inhibits secretion

Answer 44

1. a1 2. a2, b2 3. a1 4. a2

Question 45

M3 receptor function in GIT

Answer 45

Inrease secretion of salivary glands Contract sm. muscle increase secretion

Question 46

What receptor mediates relaxation of sphincter muscles in GIT?

Answer 46

M2

Question 47

What receptor increases (Psy) secretion in GIT

Answer 47

M1 and M3

Question 48

Bladder wall receptors (and nerve that stimulates them)

Answer 48

M3 receptor (pelvic n. Psy) B3 receptor (hypogastric nerve - Sy)

Question 49

Urethra receptor

Answer 49

a1

Question 50

Detrusor muscle receptor

Answer 50

M2

Question 51

Receptor on External urethral sphincter

Answer 51

Nicotinic

Question 52

Relaxes bladder wall

Answer 52

B3

Question 53

Parasymp. receptor in UG system

Answer 53

M3

Question 54

Contracts ureter and sphincter

Answer 54

a1

Question 55

Relaxes uterus Contracts uterus

Answer 55

B2 a1

Question 56

Ejaculation receptor

Answer 56

a1

Question 57

Glycogenolysis and GNG mediated by...

Answer 57

a1, B2

Question 58

Lipolysis mediated by \_\_\_\_\_

Answer 58

a1, B1,2,3

Question 59

Renin release mediated by

Answer 59

B1

Question 60

insulin release mediated by

Answer 60

a2

Question 61

The major cholinergic receptor for: 1. Liver 2. Fat cells 3. Kidney 4. Pancreas

Answer 61

None!