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1
Q

What are the 3 classifications of signalling molecules?

A

Endogenous - within body
Exogenous 1 - natural, plant based
Exogenous 2 - synthetic, man made

2
Q

What are the main extracellular signalling groups?

A

Endocrine
Paracrine
Autocrine

3
Q

What are the features of paracrine signalling molecules?

A

Signalling coupled from cell to cell
Molecules released into extracellular environment
Induce changes in receptor cells
E.g. neurotransmitters

4
Q

What are the primary signalling roles of neurotransmitters?

A

Excitatory - signal increase firing rate post- synaptically

Inhibitory - signal decrease firing rate post-synaptically

5
Q

What is the role of endogenous signalling molecules?

A

Carry and transfer specific signal

Optimal fit for job

6
Q

What is the role of exogenous signalling molecules?

A

Often engineered via human design to carry and transfer ‘imposter’ signal
Fit may be sub-optimal or antagonistic

7
Q

What happens when endogenous or exogenous molecules bind with a target?

A

Bring about change in functional status of target cells

Can be to transform an earlier signal to produce another chemical or electrochemical signal

8
Q

What are the signalling molecule targets?

A
Receptors
Ion channels
Transporters
Enzymes 
(RITE)
9
Q

What are the types of receptors?

A
Kinase linked receptors
Ion channels (ligand gated)
Nuclear/intracellular
G-protein coupled receptors
(K(L)ING)