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Flashcards in 1 Nucleus Structure Deck (14)
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1
Q

what do lamins connect the nuclear membrane to?

A

chromatin

2
Q

what disease class does progeria and restrictive dermopathy fall into?

A

laminopathies

3
Q

what needsd to happen to lamin in order for them to be released from chromatin during cell division?

A

phosphorylation

4
Q

during which phase does the laimin become phosphorylated

A

prophase

5
Q

during interpahse, are lamins phosphorylated?

A

No

6
Q

phosphorylation of lamins begins what process?

A

nuclear membrane dissassembly, releasing chromatin from lamin

7
Q

what is the repeat and the gene that causes huntingtons?

A

CAG repeat in the HTT gene

8
Q

what size cargo can move freely via diffusion across the nuclear membrane?

A

smaller than 5-10 kDa

9
Q

What is required of larger cargo so that is can be sent into the nucleus

A

a Nuclear Localization Signal

10
Q

what binds to the NLS signal to escort the molecule into the nucelus?

A

importins - chaperon protein

11
Q

what do proteins and ribo-nulceoproteins destined for export have?

A

nuclear export signals (NES) that are recognized by ?exportins

12
Q

what, specifically, do exportins recognize on the nuclear pore?

A

5’ - Gppp site on the nuclear pore and bind to it

13
Q

what does exportin 1 specialize in exporting?

A

tumor suppressors, apoptosis inducers, and anti-proliferative molecules

14
Q

what protein, having to do with nuclear transport, is greatly over expressed in some types of cancer?

A

exportin 1 - keeping a lot of anti-proliferative molecules out of the nucleus so they can not exert an effect.