Flashcards in 1 Nucleus Structure Deck (14):
what do lamins connect the nuclear membrane to?
what disease class does progeria and restrictive dermopathy fall into?
what needsd to happen to lamin in order for them to be released from chromatin during cell division?
during which phase does the laimin become phosphorylated
during interpahse, are lamins phosphorylated?
phosphorylation of lamins begins what process?
nuclear membrane dissassembly, releasing chromatin from lamin
what is the repeat and the gene that causes huntingtons?
CAG repeat in the HTT gene
what size cargo can move freely via diffusion across the nuclear membrane?
smaller than 5-10 kDa
What is required of larger cargo so that is can be sent into the nucleus
a Nuclear Localization Signal
what binds to the NLS signal to escort the molecule into the nucelus?
importins - chaperon protein
what do proteins and ribo-nulceoproteins destined for export have?
nuclear export signals (NES) that are recognized by ?exportins
what, specifically, do exportins recognize on the nuclear pore?
5' - Gppp site on the nuclear pore and bind to it
what does exportin 1 specialize in exporting?
tumor suppressors, apoptosis inducers, and anti-proliferative molecules