1 Nucleus Structure Flashcards Preview

Cell Biology > 1 Nucleus Structure > Flashcards

Flashcards in 1 Nucleus Structure Deck (14):
1

what do lamins connect the nuclear membrane to?

chromatin

2

what disease class does progeria and restrictive dermopathy fall into?

laminopathies

3

what needsd to happen to lamin in order for them to be released from chromatin during cell division?

phosphorylation

4

during which phase does the laimin become phosphorylated

prophase

5

during interpahse, are lamins phosphorylated?

No

6

phosphorylation of lamins begins what process?

nuclear membrane dissassembly, releasing chromatin from lamin

7

what is the repeat and the gene that causes huntingtons?

CAG repeat in the HTT gene

8

what size cargo can move freely via diffusion across the nuclear membrane?

smaller than 5-10 kDa

9

What is required of larger cargo so that is can be sent into the nucleus

a Nuclear Localization Signal

10

what binds to the NLS signal to escort the molecule into the nucelus?

importins - chaperon protein

11

what do proteins and ribo-nulceoproteins destined for export have?

nuclear export signals (NES) that are recognized by ?exportins

12

what, specifically, do exportins recognize on the nuclear pore?

5' - Gppp site on the nuclear pore and bind to it

13

what does exportin 1 specialize in exporting?

tumor suppressors, apoptosis inducers, and anti-proliferative molecules

14

what protein, having to do with nuclear transport, is greatly over expressed in some types of cancer?

exportin 1 - keeping a lot of anti-proliferative molecules out of the nucleus so they can not exert an effect.