100 important drugs to know - part 1 Flashcards Preview

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Flashcards in 100 important drugs to know - part 1 Deck (43):
1

Digoxin indication

- AF or flutter
- heart failure

2

Digoxin contra-indications

- constrictive pericarditis
- hypertrophic cardiomyopathy
- intermittent complete heart block
- myocarditis
- second degree AV block
- SVT arrhythmias eg WPW syndrome
= VF

3

Digoxin common or very common SE

- arrhythmia
- blurred/yellow vision
- d+v
- eosinophilia/ rash

4

Digoxin monitoring

Us/Es

5

Digoxin drug class

cardiac glycoside

6

Bendroflumethiazide indications

Oedema
Hypertension

7

Dose of Bendroflumethiazide for HTN

2.5 mg OD

8

Dose of Bendroflumethiazide for oedema

5-10 mg OD or alternate days

(1-3/7 for maintenance)

9

Contra-indications of Bendroflumethiazide

- addisons
- high Ca, urea
- low K, Na

10

Cautions with Bendroflumethiazide

- DM
- gout
- SLE

11

Monitoring for Bendroflumethiazide

Us/Es

12

Drug class of Bendroflumethiazide

thiazide diuretics

13

Furosemide mech of action

Loop diuretic; inhibits reabsorption

14

Furosemide indications

oedema
resistant oedema/ HTN

15

Dose of furosemide for oedema (non resistant)

start with 40 mg OD, maintain 20-40 mg OD

16

Dose of furosemide for resistant HTN

40-80 mg OD PO

17

Contra-indications of furosemide

renal failure
low Na or K

18

Main SE of furosemide

- hepatic impairment due to low K- could lead to encephalopathy and coma
- renal impairment
- tinnitus and deafness if rapidly administrated

19

Monitoring of furosemide

Us and Es

20

Spironolactone indications

- Oedema due to heart failure
- Ascites due to cirrhosis of liver
- nephrotic syndrome
- resistant HTN

21

Dose of spironolactone for oedema

100-400 mg OD

22

Dose of spironolactone for HTN

25 mg OD

23

Contra indications to spironolactone

Addisons
Anuria
High K

24

Monitoring of spironolactone

Plasma K levels- high risk of hyperkalaemia

25

Drug class of spironolactone

aldosterone antagonist

26

Indications of Co-amilofruse

oedema

27

What is co amilofruse made of

amiloride + furosemide

28

Amiloride indications

- oedema
- K conservation when used with other diuretics

29

Dose of amiloride for oedema

10 mg OD or 5mg BD

max daily =20mg

30

Monitoring of amiloride

monitor electrolytes (high risk of hyper K)

31

Adenosine indication

- rapid reversion to sinus rhythm from SVTs
- used in myocardial perfusion imaging in patients who cannot exercise adequately

32

Dose of adenosine for rapid reversion to sinus rhythm

- 6mg IV over 2secs,
- followed by a possible 2 more 12mg doses 1-2 min apart if required

33

Contra-indications of adenosine

- asthma, copd
- decompensated heart failure
- Long QT
- 2/3rd degree HB
- severe hypotension

34

Common SEs of adenosine

- angina (discontinue if)
- apprehension
- arrhythmia, AV block
- SOB
- nausea
- headache, dizziness

35

Monitoring for adenosine

ECG monitoring

resus facilities should be available

36

Amiadarone indication

- arrhythmias
- If Refractory to defib: ventricular fibrillation or pulseless ventricular tachycardia

37

Amiadarone dose

PO: 200 mg TDS 3days 1st wk, then 200mg BD for 2nd wk, then 20mg OD

IV: 5mg/Kg over 20-120 mins, max 1.2 g daily

38

Interactions of amiodarone

very long half life
interactions may occur several wks/months after taking

39

Common SEs of amiodarone

- Low HR
- high/low thyroid
- pulmonary toxicity
- jaundice, nausea/ vomiting
- grey skin discolouration, phototoxicity
- reversible corneal microdeposits

40

Monitoring of amiadarone

Every 6 mo:
- TFT
- LFTs
Before start :
- K, LFTs, TFT
- CXR

41

Monitoring of iv amiadarone

ECG monitoring and resuscitation facilities must be available.
- plus liver transaminases

42

Concomitant use of which drugs and amiadarone should be avoided

Hep C anitretroviral rx:
sofosbuvir and daclatasvir, simeprevir and sofosbuvir, or sofosbuvir and ledipasvir

43

Why should avoid treating hep c and amiadarone at the same time

risk of severe bradycardia and HB