Neurophys

Question 1

5HT-3 antagonism helps with

Answer 1

Depressed mood and cognitive symptoms

Question 2

Stimulation of 5HT-3 receptors leads to

Answer 2

Stimulation of 5HT-3 receptors inhibits NE and ACh release leading to depressed mood and cognitive dysfunction

1. Binds to GABAergic neurons on 5HT-3 sites —> release GABA onto nor adrenergic and cholinergic neurons—> reduces release of an NE and a ACh
2. Inhibits release of NE and ACh when it binds to 5HT-3 receptors on adrenergic and cholinergic neurons

Question 3

Stimulation of which serotonin receptor causes sexual dysfunction?

Answer 3

5HT-2 stimulation causes downstream decrease in DA

Question 4

5HT-3 ANTagonism benefits:

Answer 4

Improved cognition,
Less depressive mood
Anxiolytic
Reduce EPS

Question 5

5HT-6 receptors (antagonism)

Answer 5

Regulates the release of the BDNF and aspects of learning and memory

Question 6

5HT-2C receptor antagonism causes?

Answer 6

Normally, 5HT excites GABA interneurons by stimulating 5HT-2C receptors which increases the release of GABA. GABA can then bind to GABA-A receptors on noradrenergic and dopaminergic neurons. Since GABA is inhibitory, it prevents these neurons from releasing NE and DA

5HT-2C antagonism leads to disinhibition of monoaminergic neurons and increased NE & DA in
Prefrontal cortex —> Improved mood and cognition

Question 7

Main signs and symptoms that distinguish neuroleptic malignant syndrome from serotonin syndrome

Answer 7

In serotonin syndrome hyperactivity symptoms including tremor hyperreflexia, and myoclonus oppose the decreased reflexes and muscle rigidity seen in neuroleptic malignant syndrome