E. coli T3SS Flashcards
1
Q
What is T3SS?
A
Contact dependent protein secretion system
Injects Tir and other proteins into host over IM and OM
2
Q
What do the effector proteins do once in the host cell?
A
Subvert normal host cell functions to promote injection
3
Q
What are the effector proteins responsible for?
A
Attaching and effacing phenotype (EPEC onto pedestal)
4
Q
What are examples of the effector proteins?
A
Translocated intimin receptor (Tir)
Mitochondrial associated protein (Map)
5
Q
Why is Tir injected into the cell?
A
The receptor is injected so E. coli O157:H7 can adhere with intimin
