DNA Mutagenesis and Repair

Question 1

A loss of function mutation is also known as?

Answer 1

Recessive muations

Question 2

A gain of function mutation is also known as?

Answer 2

Dominant mutations

Question 3

This type of mutation occurs when two acentric nonhomologous chromosomes trade places afer double stranded breaks

Answer 3

Reciprocal translocation

Question 4

This type of mutation occurs when a break causes a 180 degree flip

Answer 4

Inversion

Question 5

These inversions do not include the centromere

Answer 5

Paracentric Inversions

Question 6

Imbalanced mutations are mutations that involve a change in what parameter of genes?

Answer 6

Number

Question 7

Imbalanced mutation where there is a loss of a segment in one chromosome

Answer 7

Deletion

Question 8

Imbalanced mutation where there is a duplication of a segment in one chromosome

Answer 8

Duplication mutation

Question 9

Gene conversion is more common in:
A. Mitosis
B. Meiosis

Answer 9

Meiosis

Question 10

This is a mutation where a region is replicated many times over outside a given chromosome

Answer 10

Gene amplification

Question 11

This is a mutation wherein genes appear in a different location. e.g. Chronic Myelogenous Leukemia (BCR-ABL)

Answer 11

DNA Translocation

Question 12

A genetic change that involve the loss or gain of an entire chromosome

Answer 12

Aneuploidy

Question 13

Pu -> Pu or Py -> Py

Answer 13

Transition

Question 14

Pu -> Py or Py -> Pu

Answer 14

Transversion

Question 15

Mutations that result to a change in the amino acid translated BUT the AA created has similar properties to the correct AA

Answer 15

Conservative

Question 16

These mutations involves the change in configuration of the base pairs

Answer 16

Tautomeric shifts

Question 17

This repair strategy involves the correction a wrong nucleotide. It is carried out by DNA ligase.

Answer 17

Direct Repair

Question 18

This repair strategy involves the removal and replacement of a segment. It is carried out by DNA Glycolase

Answer 18

Base Excision Repair

Question 19

This repair strategy is involved in the removal and replacement of a large segment of ssDNA. It is associated with thymine dimerization.

Answer 19

Nucleotide Excision Repair

Question 20

A tuor suppressing protein incolced in the apoptosis of cells with irreparable DNA

Answer 20

p53

Question 21

These inversions include the centromere

Answer 21

pericentric inversions

Question 22

This is a mutation where a region is replicated many times over within a chromosome

Answer 22

Gene duplication