Zollinger-Ellison Syndrome

Question 1

What is Zollinger-Ellison syndrome?

Answer 1

rare digestive disorder

gastrinomas form in the duodenum or pancreas

Question 2

The tumors in Zollinger-Ellison syndrome increase

Answer 2

gastric secretion

Question 3

__________ in the gut causes multiple problems

Answer 3

increased acidity

Question 4

Signs & symptoms of Zollinger-Ellison syndrome include

Answer 4

peptic ulcer disease, diarrhea, weight loss, heartburn, erosive esophagitis, esophageal bleeding strictures or perforation, impaired nutrient absorption

Question 5

Describe the population most commonly affected by Zollinger-Ellison syndrome:

Answer 5

men>women

age 20-50 years

Question 6

The triad of Zollinger-Ellison syndrome includes

Answer 6

pancreatic or duodenal tumors
gastric hypersecretion
peptic ulcers

Question 7

Zollinger-Ellison syndrome differential includes

Answer 7

peptic ulcer, pyloric obstruction, and gastric cancer

Question 8

Diagnosis of Zollinger-Ellison syndrome is via

Answer 8

PUD
MENI
or fasting gastrin level test- gastric pH less than 2 with serum gastrin levels 10x normal

Question 9

Treatment of Zollinger-Ellison syndrome includes

Answer 9

proton pump inhibitor
H2 antagonist
surgical resection- stage and location must be established
rule out MENI as potential cause

Question 10

Surgical considerations for Zollinger-Ellison syndrome includes

Answer 10

increased gastric volume
esophageal reflux
diarrhea- electrolyte imbalance & fluid imbalance
RSI
vital signs may be labile
maintain normothermia, normocarbia & renal function