Lecture 25+26+DLA Flashcards

1
Q

potential ADE

A

an error that is intercepted before reaching the patient

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2
Q

preventable ADE

A

an error that reaches the patient and causes some degree of harm

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3
Q

non-preventable ADE

A

an adverse outcome though medications are prescribed and administered appropriately

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4
Q

the causes of medication errors

A
  1. patient specific causes
    EX: elderly taking multiple medications are more vulnerable to ADE
  2. drug specific causes
    EX: look alike or sound alike meds
  3. clinician specific causes:
    unnecessary drug prescription, transcribing errors, dosage errors, failure to identify a drug allergy
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5
Q

how to to reduce medication errors?

A

transcription training

using the 5R’s
(right drug, right patient, right does, right route, right time)

CPOE (computerized physician order entry)

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6
Q

how to reduce hospital-acquired infections

A
  1. hand washing- single most affective method

more sinks
more alcohol based hand rubs
no artificial nails
changing gloves

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7
Q

risk factors for patient falls

A
  1. over the age of 60
  2. taking multiple drugs (sedatives, hypnotics, antidepressants)
  3. impaired memory
  4. difficulty walking
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8
Q

how to reduce patient falls

A
  1. identify high risk people
  2. education
  3. safety rounds
  4. bed alarms
  5. safety companions
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9
Q

no-fault errors

A

Result from factors outside the control of the clinician or the health care system

Ex: atypical disease presentation
patient providing misleading info; uncooperative

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10
Q

systems-related error

A

The result of technical or organizational flaws

EX: 
inadequate communication and care coordination 
inefficient processes
technical failure  
equipment issues
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11
Q

cognitive errors

A

diagnoses that are wrong, missed, or unintentionally delayed due to clinician error

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12
Q

Anchoring bias

A

A wrong diagnosis made when clinician maintains initial
impressions when making a diagnosis, and becomes
dismissive to signs and symptoms that points to another diagnosis

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13
Q

confirmation bias

A

Looking for evidence and interpretation of information to fit a preconceived diagnosis rather than the converse

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14
Q

Availability bias

A

More recent and readily available answers and solutions are preferentially favored because of ease of recall and incorrectly perceived importance

most cognitively available diagnosis

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15
Q

Diagnosis Momentum

A

When the diagnosis considered by one clinician becomes the definitive diagnosis as it passed from one clinician to the next; it then becomes accepted without
question by clinicians down the line

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16
Q

framing effect

A

Diagnostic decision-making unduly biased by extraneous and collateral information

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17
Q

slips (medical error)

A

Actions not carried out as intended or planned

Ex: giving an iv injection instead of subcutaneous

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18
Q

lapses (medical error)

A

missed actions and omissions

ex: forgetting to monitor a patient and replacing serum K in a patient with AHF

19
Q

Mistakes (medical error)

A

A wrong intended action

e.g., a faulty plan or incorrect intention

20
Q

violation

A

not a type of medical error

Deliberate actions whereby someone does something and knows it to be against the
rules

EX: deliberately failing to follow proper procedures

21
Q

near-miss (outcome of medical error)

A

Errors that occur but do not result in injury or harm to patients because they are caught in time or simply because of luck

22
Q

adverse events (outcomes of medical errors)

A

Harm or injury that results directly from the management of a patients’ disease or condition by health care professionals rather than by the underlying disease or condition itself

23
Q

Sentinel event (outcome of medical error)

A

Adverse event in which death, permanent or severe temporary harm to a patient has occurred; used to refer to events that were not at all expected or acceptable

24
Q

Never Event / Serious Reportable Events (outcome of medical error)

A

adverse events in medical care that are clearly identifiable, preventable, and serious in their consequences for patients, and that indicate a real problem in the safety and credibility of a health care facility

Ex: 
surgical events
product events 
care management events 
potential crime event
25
Q

Factors that contribute to Unsafe Care

A
communication and teamwork failure 
errors at hand off 
stress and fatigue 
poor working conditions 
lack of education
26
Q

what mediates signaling in B cell receptors?

A

Ig alpha and Ig beta

BCR’s are antibodies

27
Q

the light chain

A
The amino (N) terminal domain is variable and the site
of antigen binding

the constant domain at the carboxy terminal; it can be kappa or lambda

28
Q

The heavy chain

A

this chain determines the 5 classes of Ig: G, A, M, E, and D

Constant region (C): nearly invariant; not involved in
antigen binding
29
Q

IgG

A

monomer, produced by plasma cells (primary
response) and memory cells (secondary), most prevalent

2 binding sites
most common in serum
can cross placenta
binds to phagocytes

long term immunity
memory Ab’s
neutralizes toxins and viruses

30
Q

IgA

A

2 or 4 binding sites
does not cross placenta
binds to epithelial cells

secretory Ab on mucous membranes

31
Q

IgM

A

10 binding sites
does not cross placenta
first to be produced in response to antigen

can serve as a B cell receptor

32
Q

IgD

A

2 binding sites
does not cross placenta
receptor on B cells for antigen recognition

33
Q

IgE

A

2 binding sites
does not cross placenta
binds to mast cells and basophils

the antibody of allergy; worm infections

34
Q

T cell receptor

A

heterodimer recognizes peptides displayed by MHC
molecules

composed of an alpha and beta chain
each with a V and C region

do not undergo class switching

35
Q

TCR complex

A

it can recognize the antigen but does not transmit signals

complex with 3 dimers

associated with CD3
needs a coreceptor (CD 4 or 8)

36
Q

Lymphopoiesis

A

B cell production occurs throughout life; does not
wane as does T cell production

process in which lymphocytes develop from progenitor cells

37
Q

B cell development

A

the goal is to produce plasma and memory cells

  1. antigen-independent phase (bone marrow)
  2. antigen-dependent phase
  3. Differentiation of active B cells into plasma and
    memory cells
38
Q

antigen independent phase of B cell development

A
pro B cells: 
expression of CD45R and CD 19 
IL 7 supports this process 
successful re-arrangement of the ig heavy chain = pre-B cells 
Tdt catalyzes the heavy chain coding  

pre-B cells:
seen to have igu heavy chain in cyto
induce recombination of ig light chains

39
Q

BTK

A

Bruton’s tyrosine kinase (BTK) is a kinase that plays a
crucial role in B-cell development

Mutations in the BTK gene are implicated in the primary
immunodeficiency disease: X-linked agammaglobulinemia (XLA)

the pre-B cells fail to mature

BTK inhibitors are used in the treatment of some cancers and autoimmune diseases

40
Q

immature B cells

A

IgM is expressed on the surface
negative selection occurs (clonal deletion)
functional B cell receptor appears

41
Q

mature B cell expresses?

A

IgM and IgD

involves a change in RNA processing of the heavy chain

42
Q

naive B cells

A

migrate out of the bone marrow
no dividing
no antigen encounter

43
Q

negative selection; thymocyte

A

Elimination of any CD4 or CD8 cells that have
high affinity to selfMHC alone or to self MHC-self epitope complexes

these cells are programmed to die
ensures self-tolerance

44
Q

AIRE

A

autoimmune regulator; transcription factor expressed in the medulla of the thymus

drives negative selection of T cells ( so body does not attack itself)

when AIRE is defective it can lead to autoimmune disease