7- Emerging infectious disease 2 Flashcards

1
Q

family of zika virus

A

flaviviridae

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2
Q

when was zika virus first identified

A

from sentinel monkeys for yellow fever

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3
Q

transmission of zika virus

A

aedes aegypti, aeded albopictus

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4
Q

cycles of biting for aedes bugs with zika

A

sylvanic cycle

sub urban, urban cycle

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5
Q

vertical transmission and sexual transmission of zika to fetuses causes

A

fetuses have cerebral abnormalitis (microcephaly), is found in semen

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6
Q

zika virus is asymptomatic in the majority of infected people

A

true

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7
Q

frequent manifestations of zika

A

fever, rash, arthralgia, conjunctivitis

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8
Q

tx of zika

A

is usually self limiting, resolves spontaneously after 3-7 days, but arthralgia can persist for 1 month
there can also be post infection asthenia

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9
Q

dx of zika

A

rRT-PCR in serum, urine, blood

IgM IgG

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10
Q

genus of west nile virus

A

flavivirus

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11
Q

west nile causes what brain deformity

A

encephalitis

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12
Q

T/F west nile virus causes both sporadic infection and outbreaks that can be associated with severe neurological disease

A

T

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13
Q

what transmits west nile virus

A

mosquitoes of Culex species

  • culex pipiens pipiens (nothern house mosquito) is a maintenance vector in north US and canada
  • culex pipiens quinquefasciatus (southern house mosquitoes) are for south US
  • culex tarsalis is for west US and canada
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14
Q

T/F birds develop prolonged high levels of viremia and serve as amplifying hosts for west nile virus, and they often remain asymptomatic

A

T

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15
Q

T/F west nile virus has no symptoms in most people

A

T

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16
Q

characteristics of neuroinvasive disease for west nile virus

A
  • clinical manifestation of meningitis were similar to other menningitis
  • encephalitis can be mild self limiting confusion to severe encephalopathy, coma and death
  • can also cause acute flaccid paralysis syndrome
17
Q

DX of west nile virus

A

serology IgM and IgG serum and CSF

- PCR based assay serum, CSF, urine

18
Q

tx for west nile virus

A

no vaccine, no specific antiviral treatments exist

19
Q

MERS causes

A

severe atypical pneumonia

20
Q

MERS vs SARS

A

both coronavirusis

MERS has GI symptoms, SARS doesnt