29- Vaccine Flashcards
BCG for children?
only in kids who have a negative TST, and who are continuously exposed to infected adults
- have have TB due to strains resistant to ironiazid and rifamipicin
who not to give BCG to
- immunosuppressed
- pregnancy
can live attenuated vaccines cause dx
no, they elicit strong body responses tho, so confer lifetime immunity with only one or two doses
live attenuated viral vaccines examples
measles, mumps, rubella, VZV, yellow fever, rotavirus, intranasal influenza, rotavirus
live attenuated bacterial vaccines eg
BCG, oral typhoid
T/F Because subunit vaccines contain only the essential antigens and not all the
other molecules that make up the microbe, the chances of adverse reactions
to the vaccine are lower
T
how to make a conjugate vaccines
By covalently attaching a poor
(polysaccharide organism) antigen to a carrier protein (preferably from
the same micro-organism), thereby conferring the immunological
attributes of the carrier on the attached antigen.
T/F Influenza infection during pregnancy has risks for premature birth, reduced birth weight and elevated risk of death
T
vaccine efficacy means
the direct protection to vaccinated ppl provided by the vaccine under optimal condition and focused on the prevention of clinically apparent outcomes
effectiveness of a vaccine means
the protection conferred by immunization in a defined pop
It measures both direct (vaccine induced) and indirect (pop related) protection
The total effect of immunization is
the sum of the in/direct effects on the vaccinated person that result from being vaccinated and being in a pop with an immunisation program
the overall effect of a vaccine is
the effect of the immunisation program on the entire pop that includes both vaxed and unvaxed indv
herd protection is related to
coverage
