Alkylating Agents

Question 1

MOA of alkylating agents

Answer 1

Alkylation Inh DNA replication

Question 2

Nitrogen Mustards examples

Answer 2

Mechlorethamine, Chlorambucil Cyclophosphamide, Ifosfamide, Mephalan

Question 3

Ethylenimenes/Methylmelamines examples

Answer 3

Thiotepa, Altretamine (hexamethylmelamine)

Question 4

Alkyl sulfonates examples

Answer 4

Busulfan

Question 5

Nitrosureas For brain tumors examples

Answer 5

Carmustine, Lomustine, Streptozotocin

Question 6

Triazines examples

Answer 6

Dacarbazine

Question 7

Platinum Coordination Complex examples

Answer 7

Cisplatin, Carboplatin

Question 8

Substituted Urea exmaples

Answer 8

Hydroxyurea

Question 9

Others

Answer 9

Procarbazine, Temozolamide

Question 10

WWII (vesicant), Nitrogen Mustard

Answer 10

Mechlorethamine

Question 11

(DOC for CLL)

Answer 11

Chlorambucil

Question 12

Adverse Effects of Nitrogen Mustards

Answer 12

 Bone Marrow depression
 Hemorrhagic cystitis (fibrosis of the bladder)
o Acrolein (cyclophosphamide)
MESNA (sodium 2 mercaptoethane sulfonate)
 Germ cells amenorrhea, testicular atrophy, sterility
 Neurotoxicity (ifosfamide) chloroacetaldehyde
 Secondary malignancies

Question 13

Adverse Effects of Alkyl sulfonates (Busulfan)

Answer 13

Pulmonary Toxicity

Question 14

Adverse Effects of Carmustine, Lomustine

Answer 14

Pulmonary Toxicity

Question 15

Adverse Effects of Streptozotocin

Answer 15

Toxic to beta cells of islets of Langerhans (Insulinomas)

Question 16

Adverse Effects of Cisplatin

Answer 16

 Severe persistent vomiting

 Nephrotoxicity (dose limiting)

Question 17

Adverse Effects of Carboplatin

Answer 17

 Mild nausea and vomiting
 Not nephro–, neuro–, or ototoxic
 Myelosuppression (dose limiting)