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Matt's Path COPY > Lymphomas > Flashcards

Lymphomas Flashcards

1
Q

Anaplastic Large Cell Lymphoma

A

Children and Young Adults

Aggressive

Large “Epitheloid” lymphocytes

t(2,5)

Alk-1 protein expression

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2
Q

Peripheral T cell Lymphoma

A

Middle aged and elderly

Aggressive

Large T cells

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3
Q

Adult T cell leukaemia/lymphoma

A

Caribbean and Japanese

HTLV1 Infection

Aggressive

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4
Q

Enteropathy-associated T cell lymphoma (EATL)

A

Long-standing Coeliac’s

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5
Q

Cutaneous T cell lymphoma

A

Mycosis fungoides

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6
Q

Burkitt’s Lymphoma

A

Very Agressive
Fast-growing
T(8,14) translocation
C-myc over expression

“Starry-sky” appearance

All treated with Rituximab (anti-CD20)

Endemic: Equatorial Africa, EBV-associated, “jaw involvement” and abdominal masses

Sporadic: EBV-associated, jaw less likely

Immunodeficiency: Non-EBV associated, post-transplant, HIV

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7
Q

Diffuse Large B Cell Lymphoma

A

“Sheets of large lymphoid cells”

Middle ages and elderly

Aggressive

Ritcher’s transformation
From chronic lymphocytic leukemia (CLL) and hairy cell leukemia —> DLBL

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8
Q

Mantle Cell Lymphoma

A

“Angular nuclei”

Middle aged

M>F

Aggressive

Disseminated at presentation

T(11.14)

Cyclin D1 deregulation

median survival 3-5 yrs

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9
Q

Follicular Lymphoma

A

“Follicular pattern”

“Nodular appearance”

Indolent

Incurable (mostly)

Median survival 12-15 years

T(14,18)

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10
Q

MALToma

A

H.pylori –> MALToma

T(11;18)

Sjogren’s –> Parotid lymphoma

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11
Q

Rituximab-CHOP

A

R- Retuximab

CHOP
Cyclophosphamide	750 mg/m2 i.v.		D1
Adriamycin		50 mg/m2 i.v.		D1
Vincristine 		1.4 mg/m2 i.v.		D1
Prednisolone		40 mg/m2 p.o.		D1‑D5
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12
Q

Multiple Myeloma

A

Plasma cell neoplasm

“Bence-Jones” proteins in urine

Raised ESR

Rouleaux on blood film

Dense narrow band on electrophoresis

> 10% plasma cells in bone marrow

Calcium (high) (moans, groans, thrones, stones)
Renal impairment (+amyloidosis and nephrotic syndrome)
Anaemia (+pancytopenia)
Bone pain (pepper pot skull, wedge compression, fractures, osteolytic lesions)

Hyperviscosity syndrome

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13
Q

Treatment of multiple myeloma

A 
Melphalan
Bortezomib (protease inhibitor)
Lebalidomide 
Thalidoamide 
Steroids

Auto- SCT

Supportive: bisphosphonates

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Matt's Path COPY (18 decks)

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