Myelodysplastic Syndrome

Question 1

Refractory Anaemia

Answer 1

RA

Anaemia

No Blasts

Erythroid Dysplasia with <5% blasts

Question 2

Refractory Anaemia with Ring Sideroblasts

Answer 2

RA + RS

Anaemia

No Blasts

Ring sideroblasts

Erythroid dysplasia with >15% ringed sideroblasts
<5% blasts

Question 3

Refractory cytopenia with multilineage dysplasia

Answer 3

RCMD

Cytopenia >/2 cell lines

Dysplasia in >10% cells in >/ cell lines

Question 4

Refractory cytopenia with multilineage dysplasia and ringed sideroblasts

Answer 4

RCMD+RS

Cytopenia >/2 cell lines

Dysplasia in >10% cells in >/ cell lines
With >15% Ringed sideroblasts

Question 5

Refractory anaemia with excess blasts 1

Answer 5

RAEB I

Cytopenias

<5% blasts in BLOOD
No auer rods

In Bone marrow: 5-9% blasts

Question 6

Refractory anaemia with excess blasts 2

Answer 6

RAEB II

Cytopenias

5-19% blasts in BLOOD

Auer rods

In Bone marrow: 10-19% blasts / Auer rods

Question 7

Myelodysplastic syndrome with isolated 5q deletion

Answer 7

Anaemia

Normal platelets

<5% blasts

Megakaryocytes with hypoblated nuclei

Question 8

Myelodysplastic syndrome Unclassified

Answer 8

Complex

Cytopenias

No blasts

No Auer rods