Group 3 - Lidocaine HCl

Question 1

Lidocaine HCl

Drug Class?

Answer 1

Lidocaine HCl Drug Class:

• Antiarrhythmic
• Local anesthetic

Question 2

Lidocaine HCl

Mechanism of Action (MOA)?

Answer 2

Lidocaine HCl MOA:

• Decreases automaticity
• Increases ventricular fibrillation threshold
• Slows conduction in ischemic tissue

Question 3

Lidocaine HCl

Indications?

Answer 3

Lidocaine HCl Indications:

• Suppression of ventricular arrhythmias (VT, VF, PVCs)
• Prophylaxis against recurrence after conversion from VT or VF
• Pain management after IO insertion in conscious patients

Question 4

Lidocaine HCl

Contraindications?

Answer 4

Lidocaine HCl Contraindications:

• Hypersensitivity
• Caution in patients with 2nd or 3rd degree AV blocks

Question 5

Lidocaine HCl

Adverse Reactions?

Answer 5

Lidocaine HCl Adverse Reactions:

• CV: SA nodal depression, hypotension
• CNS: Drowsiness, paresthesias, seizures, muscle twitching

Question 6

Lidocaine HCl

Adult Dose?

Answer 6

Lidocaine HCl Adult Dose:

• Pulseless VF/VT: Initial bolus of 1.0 - 1.5 mg/kg IVP every 3 - 5 minutes to a total of 3 mg/kg
• Antidysrhythmic or rhythms with a pulse: 0.5 - 0.75 mg/kg, up to 1.0 - 1.5 mg/kg IVP, with repeat boluses of 0.5 - 0.75 mg/kg every 5 - 10 minutes to a total of 3 mg/kg
• Maintenance infusion after return of spontaneous rhythm: 2 - 4 mg/min
• IO pain management: 20 - 40 mg very slow IO push

Question 7

Lidocaine HCl

Pediatric Dose?

Answer 7

Lidocaine HCl Pediatric Dose:

• Initial Bolus Dose: 1 mg/kg, may repeat 1 time in 3 - 5 minutes for VF/Pulseless VT or in 15 minutes for refractory dysrhythmias with a pulse (VT with a pulse)
• Infusion after return of spontaneous rhythm: 20 - 50 mcg/kg/min
• IO pain management: 0.1 mg/kg, not to exceed adult dose

Question 8

Lidocaine HCl

Onset of Action?

Answer 8

Lidocaine HCl Onset of Action:

• 1 - 5 minutes

Question 9

Lidocaine HCl

Peak Effects?

Answer 9

Lidocaine HCl Peak Effects:

• 5 - 10 minutes

Question 10

Lidocaine HCl

Duration of Action?

Answer 10

Lidocaine HCl Duration of Action:

• Bolus: 20 minutes

Question 11

Lidocaine HCl

AZ Drug Box Minimum Supply?

Answer 11

Lidocaine HCl

AZ Drug Box Minimum Supply:

• 3 pre-filled syringes, total 300 mg
• 1 G vial or premixed infusion, total 2 G